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Translational Medicine: Assessing the Feasibility and Challenges
Decision Resources, Inc., Sep 2006, Pages: 21
The emergence of translational medicine is an important new trend in the pharmaceutical and biotech industries. By closely linking basic research to clinical development and treatment, translational medicine promises to deliver new insights into disease processes, guide drug discovery and development, and ultimately improve patient care.
Get the Answers You Need to Shape Your Strategy:
Translational medicine relies considerably on technology. Researchers have widely adopted many technologies to identify drug targets and therapeutic candidates, but the use of these tools has not been broadly extended into the clinical trials phase of drug discovery. Which technologies are useful in translational medicine? How can these technologies improve clinical trial design?
A major strategy in translational medicine is to use biomarkers and patient data to create better animal models and preclinical assays. How can this strategy improve the selection of drug candidates for human testing? What impact will this improved selection have on clinical trial outcomes?
The choice of drug target is one of the most critical early decision points that can determine the success or failure of a drug discovery program. What criteria are required to ensure a high degree of drug target validation?
Translational medicine is an ambitious concept that requires the cooperation of many individuals and departments and many years to achieve. What issues and concerns remain, and how can they be addressed?
Scope:
Overview of translational medicine: a review of the goals and strategies used in translational medicine.
Technologies: overview of the leading technologies involved in translational medicine.
Successful targeted therapies: how the use of target validation, animal models, and biomarkers contributed to the development of imatinib (Novartis’s Gleevec).
Outlook: challenges facing the widespread adoption of translational medicine.
Technologies Mentioned in This Spectrum Report:
- AmpliChip CYP45O
- Test
- Animal models
- Biomarkers
- Chemistry
- Comparative profiling
- Digital image analysis
- Efficacy biomarker
- Histopathology
- Informatics
- Laser-capture
- microdissection
- Magnetic resonance
- imaging (MRI)
- Mass spectrometrybased
- protein profi ling
- of microdissected
- formalin-fixed tissue
- Mechanism biomarker
- Metabolic profiling
- Molecular signature
- profiling
- Outcome/inclusion
- biomarkers
- Pathology
- Positron emission
- tomography (PET)
- Protein profi ling
- Quantitative
- histopathology imaging
- RNA profi ling
- Single nucleotide
- polymorphisms (SNPs)
- Toxicology biomarker
- Tissue visualization
- Transgenic animals
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