|
|
 |
|
Viewing report
|
|
|
|
Proteomics: Promising Research, Potential Applications, And New Developments (Technical Insights)
Frost & Sullivan, Oct 2001
Proteomics research is growing at a rapid rate and has become one of the most important areas of investigation in biotechnology. There are proteomics
programs in nearly every major biotechnology and pharmaceutical firm, and critical developments are virtually impossible to track.
Technical Insights report separates the good news from the mundane by providing the following:
- A detailed overview of technological advances in development laboratories
- Identification of key companies and developers and provision of estimates of timelines for commercializing technology
- Definitions of key markets and applications
- Reporting on technology drivers as well as obstacles in the way of commercial success
- A detailed list of key contacts in the field, including names, titles, addresses, phone numbers, e-mail addresses, and URLs
Proteomics is not the study of proteins one by one, as has traditionally been done, but a highly automated endeavor operating on a massive scale.
High-throughput is the operative phrase, with increasingly sensitive assay techniques, the integration of multiple techniques into a single platform,
and robotics and computers taking the place of lab technicians. A great challenge lies ahead, therefore, for scientists to develop effective systems
with high-throughput, suitably sensitive arrays, and a complicated level of integration.
Proteins are the building blocks of tissues and cells, circulate in the blood to eliminate disease, regulate body temperature, digest food, synthesize
other proteins and small molecules, and in general perform all the work necessary to keep an organism working. Under- or overproduction of proteins
is implicated in many human diseases. Thus, knowing which genes are responsible for which proteins gives medical science a point of attack
for potentially curing many illnesses.
In the 1980s, when working with DNA and characterizing genes became easy, vast numbers of researchers in biology abandoned whatever they
were studying to pursue the glamorous field of molecular genetics. Newspapers and magazines extolled the medical miracles that would come from
identifying the gene for this disorder or that form of cancer. Investors made millions in genomic biotech.
But a group of scientists stayed behind to study proteins. They were content to labor quietly behind the scenes, out of the limelight, for one reason.
They believed proteins were the key to everything---that if you didn't understand what was happening in a cell beyond the DNA sequence of a given
gene, you didn't understand anything. Now everyone has realized these guys were right all along. Proteins are the next new thing.
The endeavor of characterizing the human proteome is an order of magnitude more complex than genomics. Additional new technologies and
refinements of standard techniques are needed urgently, and considerable effort is being devoted to the development of novel tools for the pro-teomics
trade.
Proteomics is an intensely more difficult field of study. One paramount reason for this is that the one-gene, one-protein hypothesis is disproved.
Many genes produce multiple proteins via alternative splicing of mRNA transcripts, proving that there are many more proteins in human cells than
there are genes in the human genome.
Customers who bought this item also bought
Proteomics - Technologies, Markets and Companies
Proteomics - Global Strategic Business Report
Genomics World Markets 2008
Transforming Drug Discovery through Genomics and Proteomics
Drug Discovery--European Advances in Genomics and Proteomics (Technical Insights)
Automation in Proteomics and Genomics: An Engineering Case-Based Approach
Technology Developments in Functional Proteomics (Technical Insights)
Proteins: From Analytics to Structural Genomics
Plant Proteomics
Proteomics - International Market Trends
Clinical Proteomics: Rethinking Approaches to Protein Biomarker Discovery
Mass Spectrometry of Protein Interactions
|
|
|
|
