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Targeted Cancer Therapies: Innovative Drugs And Their Impact On The Future Of Oncology
Business Insights, Aug 2004, Pages: 155
Targeted Cancer Therapies
Innovative drugs and their impact on the future of oncology
Acknowledgements 9
Executive summary 12
Beyond the blockbuster model 12
Emerging therapies 13
Therapy area analysis 14
Case studies 15
Conclusions 16
Chapter 1 Beyond the blockbuster model 18
Summary 18
Introduction 19
Beyond blockbusters – the development of targeted therapies 21
Declining R&D success rates 24
R&D spend in Europe and the US 26
No economies of scale in pharmaceutical R&D 30
The performance gap in R&D 32
Mergers as a driver of productivity gains 33
R&D pipeline and drug discovery trends 34
Therapeutic focus of clinical pipeline activity 36
Projects by therapeutic focus 36
Drug discovery deals 37
Implications of the move away from the blockbuster model 39
Chapter 2 Emerging therapies 44
Summary 44
Introduction 45
Current therapies 46
An overview of cancer treatment 46
The basis for targeted therapies 46
A promising therapeutic field 47
Molecularly targeted therapies 48
Regulatory risk-benefit evaluation vs. the use of surrogate endpoints for clinical efficacy 48
Efficacy criteria 49
Targeted therapies as a means to improving survival rates 50
Current treatments by type 52
Global analysis 52
Hormonal therapies 53
Cytotoxics 54
Innovative cancer therapies 55
Angiogenesis inhibitors 56
Immunostimulators 57
Tumor-targeted agents 58
Adjunct therapies 58
Advances in diagnosis 59
Introduction 59
Genetic counseling 61
OncoAssist 62
CeMines 63
Xantos Biomedicine 64
Advances in treatment 65
Pursuing biological therapies or small molecule inhibitors 65
From cytotoxic to cytostatic 66
Angiogenesis – a promising new approach to cancer treatment? 68
Differentiation therapy – developing HDAC inhibitors as anti-cancer drugs 70
Progress in oncogenics 71
Regional differences in access to healthcare 73
Chapter 3 Therapy area analysis 78
Summary 78
Introduction 79
Epidemiology 79
Current treatments 80
Current therapeutics 80
A new biologic approach for the treatment of metastatic breast cancer 81
Showing promise in the treatment of breast cancer 83
Profile: Cancer treatment in the UK 85
New treatments in breast cancer: predictions 86
Unmet needs 86
Key players in breast cancer 88
Colorectal cancer 89
Epidemiology 89
Current treatments 90
Current therapeutics 91
Treatment preferences in US and Europe 91
Unmet needs 93
Key players in colorectal cancer 94
Lung cancer 96
Epidemiology 97
Current treatments 98
NSCLC 98
SCLC 99
Malignant mesothelioma 99
Current therapeutics 99
Unmet needs 100
Key players in lung cancer 101
Prostate cancer 103
Epidemiology 103
Current treatments 104
Unmet needs 106
Key players in prostate cancer 107
Chapter 4 Case studies 110
Summary 110
Introduction 110
Sanofi-Aventis 111
Sanofi-Synthélabo 111
Eloxatin 111
Sales forecast 112
Aventis: development of oncology as a blockbuster franchise 112
Aventis’ cancer portfolio and R&D pipeline 114
Taxotere 116
Core strategies for growth 117
Recent and expected approvals 117
Taxotere as a specialty blockbuster 119
Roche 120
Introduction 120
R&D alliances, partnerships and acquisitions 121
Roche’s cancer portfolio and R&D pipeline 125
Focus on new technologies and diagnostics 128
Tarceva 131
Sales forecast 131
Genentech 132
Avastin 132
Sales forecast 135
AstraZeneca 136
Iressa 137
Physician rating of Iressa 138
Sales forecast 139
Brief profiles 140
Bristol-Myers Squibb 140
Eli Lilly 141
GlaxoSmithKline 142
Merck KGaA 143
Novartis 144
Pfizer 146
Schering AG 147
Chapter 5 Conclusions 150
Challenges for development of targeted cancer therapies 150
Diagnostics are integral to targeted therapies 151
European companies will dominate targeted cancer therapies 152
The future of oncology 153
Beyond targeted medicines 154
Index 155
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