Structure-Guided Drug Design: Rediscovering the Importance of Drug Structure for Drug Discovery
Drug and Market Development Publishing, Nov 2004, Pages: 500
The pharma industry is in a bad way. There are three major reasons for this self-inflicted malaise:
- a total preoccupation with the next blockbuster at the expense of other projects,
- an obsession with technological innovation leading to an “arms-race,” and
- an unsustainable strategy for improving corporate status by buying up the competition.
These are fundamental problems that cannot be resolved by new concepts of drug design. But the rediscovery of the importance of structure, especially in molecular interactions, can be a conceptual focus for restructuring the pharma industry for a new period of sustained growth. Structure-guided drug design is a guide to the rediscovery of the importance of structure, for the whole of the drug discovery pipeline. It is not a report on how drug discovery used to be done in the past, but how it will be done in the future.
