|
|
 |
|
Viewing report
|
|
|
|
Protein Microarrays: Technology Adoption & Utilization
BioInformatics, LLC, Sep 2005, Pages: 143
As protein arrays have become increasingly consistent and reliable, more scientists have recently begun to incorporate them into their proteomics experiments. Researchers are attracted by the technology's ability to detect protein expression more quickly and easily than traditional approaches such as 2D gel electrophoresis and mass spectrometry. By allowing scientists to look at multiple protein interactions simultaneously, the seemingly insurmountable challenge of characterizing an organism's entire collection of proteins (i.e., proteome) is within reach.
While there is tremendous excitement about the potential of protein arrays to further our understanding about protein expression, function and structure on a microscopically global level, there is also hesitancy on behalf of many scientists to adopt a technology that is often still perceived as unstable and irreproducible. This report, Protein Microarrays: Technology Adoption & Utilization, provides life science suppliers with actionable insights on how to overcome this stigma and convert proteomics researchers into future customers.
In addition to dispelling any lingering misconceptions about the technology's performance, suppliers also face substantive issues related to product development. In particular, these are key decisions about array content. To inform decision makers, this report examines the most critical factors related to array content as specified by both current and future protein microarray users:
- Molecular interactions preferred
- Applications performed
- Protein classes studied
- Number of proteins arrayed (i.e., density)
- Replicates required
- Samples per array analyzed
One emerging trend in array content is comprehensive proteome arrays, which represent all the major proteins of a target organism. While in their early stages, these so-called whole proteome arrays will forge high-throughput analysis and comprehensive measurements into a powerful tool for deciphering a plethora of proteins. Despite their promise of omnipotence, the market demand for whole proteome arrays has previously been uncertain. This report assesses scientists' level of interest in this type of array. Additionally, it identifies which collections of proteins would be most desirable to print and how much scientists would be willing to pay for these high-density arrays.
Differences in array content translate into performance metrics such as dynamic range, reproducibility and resolution. By analyzing scientists' valuation of these metrics, this report provides suppliers with pricing models to effectively position their protein array technology in the proteomics market. Furthermore, it also examines other key drivers of protein array usage such as company reputation, product support and vendor agreements. While offering concrete measures by which suppliers can enhance their technologies' competitive advantages, Protein Microarrays: Technology Adoption & Utilization, also offers first-hand knowledge on overcoming frustrating technical limitations that currently hamper scientists' investigations and limit the widespread use of protein array technology.
Report Highlights
Protein Microarrays: Technology Adoption & Utilization contains over 40 charts and/or tables and more than 15 cross-tabulations for the 39 survey questions (see Page 4). Below is a glimpse of the key findings derived from just a few of the survey questions:
- Slightly more than half of respondents use recombinant-based proteins in their protein array experiments. (Question 2)
- Antibody:antigen binding is the most popular type of array content for current protein array users from both industry and academia. Protein:protein interactions are preferred for future protein array users from academia. (Question 10)
- Of all the respondents, only 2% of current protein array users and 3% of future protein array users would not be interested in a whole proteome array. (Question 13)
- BD Biosciences and Invitrogen are top suppliers of protein microarrays. (Question 30)
- Demonstrating 'proof of concept' for new applications would be the most desired improvement requested by survey respondents. (Question 38)
Methodology
842 scientists completed a 39-question survey, (Arlington, Virginia, USA) between September 6 and September 12, 2005.
The electronic questionnaire was fielded to registered members of The Science Advisory Board. sponsors The Science Advisory Board, an online community of more than 26,000 scientists, physicians and healthcare professionals from around the world. The Science Advisory Board is divided into two panels (Research and Clinical) and 'convenes' regularly via the World Wide Web (www.scienceboard.net) to voice their opinions on a wide variety of issues relating to biomedical research and clinical technologies. These experts—representing all aspects of the life sciences and medicine—have agreed to make themselves available to participate in our online research activities. The Science Advisory Board members who participated in this study were drawn from the Board's Research Panel.
The 283 respondents who currently use protein microarrays answered Questions 1 through 4 and Questions 10 through 39. The 410 respondents who plan to use protein microarrays completed Questions 1 through 16 and Questions 38 through 39. The 149 respondents who do not plan to use protein microarrays answered Questions 1 through 9 only. Additionally, Questions 28 through 29, Questions 31 through 32, and Questions 35 through 36 were asked with regard to the primary supplier identified in Questions 27, 30 and 34, respectively.
Objectives
The major objectives of this report are as follows:
- Identify the key experimental parameters of protein microarray technology for both current and future users.
- Ascertain the reasons why researchers utilize protein microarrays.
- Identify factors that might induce researchers reluctant to adopt the technology to use protein microarrays.
- Determine current levels of throughput and estimate change in throughput over the next 12 months.
- Identify the preferred suppliers of protein microarray slides, products for self-printing of arrays and microarray readers.
- Measure respondents' levels of satisfaction with key attributes of protein microarrays and microarray readers.
- Determine the factors that influence respondents' decisions to choose one supplier over another for protein microarrays and readers.
- Understand respondents' expectations for future innovations in protein microarray technology.
Customers who bought this item also bought
Microarray Markets
World Protein Arrays Markets
The Future of Array Technologies: Impact on Drug Discovery and Market Growth in DNA, Protein
Protein Arrays: Commercial Opportunities, Legal Trends, and Technology Analyses
Trends In Protein Intake: Attitudes and Behaviors
Clinical Proteomics: Rethinking Approaches to Protein Biomarker Discovery
Beyond Expression Arrays: Emerging Applications for Genomic Microarray Technology
A Guide to Green-Fluorescent Protein
Mass Spectrometry of Protein Interactions
Protein Ingredients - Global Strategic Business Report
The Market For DNA Microarrays: Core Lab & End-User Perspectives
U.S. DNA Microarray Markets
|
|
|
|
