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Microarray Markets
TriMark Publications, Sep 2008, Pages: 132
1. Overview 4
1.1 Statement of Report 4
1.2 About This Report 4
1.3 Scope of the Report 5
1.4 Objectives 6
1.5 Methodology 6
1.6 Executive Summary 7
2. Overview of Microarrays 9
2.1 History of Microarrays 9
2.2 Genomics and Proteomics 10
2.2.1 Genetic Variability and Disease 11
2.3 General Theory of Microarrays 11
2.4 DNA Microarrays 12
2.5 Protein Microarrays 14
2.6 Tissue Microarrays 15
3. DNA Microarrays 17
3.1 Advantages and Drivers 17
3.2 Limitations and Barriers to Commercialization 18
3.3 DNA Microarray Technology Platforms 19
3.3.1 Reasons Why Researchers Utilize DNA Microarrays 23
3.3.2 Factors for Difficulties Applying DNA Microarrays Technology 23
3.4 Key Attributes of DNA Microarray Software 24
3.5 Applications 24
3.6 Future Directions for DNA Microarray Technology 29
3.6.1 High-Throughput Array Technology 29
3.6.2 Emerging Microarray Trends 31
3.6.3 Emerging Microarray Applications 31
3.6.4 Key Points for Developing Microarray Based Applications 32
4. Protein Microarrays 33
4.1 Critical Factors for Microarray Content 33
4.2 Key Findings on Use of Microarrays 33
4.3 Advantages and Drivers 34
4.4 Limitations and Barriers to Commercialization 36
4.5 Key Experimental Parameters of Protein Microarray Technology for Current and Future Users 38
4.6 Reasons Why Researchers Utilize Protein Microarrays 39
4.7 Factors for Adoption of Protein Microarrays Technology 39
4.8 Top Suppliers of Protein Microarray Slides and Products 40
4.9 Factors that Influence Sale Decisions 40
4.10 Future Innovations in Protein Microarray Technology 40
5. Current DNA Microarrays 41
5.1 Key Players 41
5.2 High Growth Applications 43
5.2.1 Microarray-Based Commercial Genotyping Activity 43
5.2.2 Location Analysis 43
5.3 Future Innovations in DNA Microarray Technology 43
6. Current Protein Microarrays 45
6.1 Protein Profiling Microarrays-Antibody Arrays 45
6.2 Protein Profiling Microarrays-Reverse Phase Microarrays 47
6.3 Multiplex Sandwich Microarrays-Planar 48
6.4 Multiplex Sandwich Immunoassays-Bead Based 50
6.5 Microarrays for Protein Function Studies 52
6.6 High Growth Applications 54
6.6.1 Cytokine Arrays 54
6.6.2 Whole Proteome Arrays 54
6.6.3 Microarray-Based Commercial Genotyping Activity 54
6.6.3.1 Microarray-Based Genotyping Applications 54
6.6.3.2 Microbial Applications 55
6.6.3.3 The Market for Microbial Genotyping Products 56
6.6.3.4 Comparative Genomic Hybridization 56
6.6.4 ChIP-on-Chip Analysis 57
7. Technology 59
7.1 Production of Microarrays 59
7.2 2-D Versus 3-D Technology 61
7.3 Substrates and Surface Chemistries 61
7.4 Detection Methods 63
7.5 Instruments 63
7.6 Data Management and Informatics in Gene Expression 64
8. Applications 65
8.1 DNA Microarrays in Gene Expression 65
8.2 DNA Microarrays in SNP Analysis 68
8.3 DNA Microarrays in Cancer 69
8.4 Protein Expression 69
8.4.1 Cytokine Applications 70
8.4.2 Protein Function 70
8.4.3 Protein-Protein Interactions 71
8.5 Target /Biomarker Discovery 71
8.6 Drug Discovery and Development (Gene and Protein Microarrays) 72
8.7 Clinical Diagnostics (Gene and Protein Microarrays) 72
8.8 RNA Microarrays 73
8.9 Oligo Microarrays 73
8.10 Yeast Microarrays 74
8.11 Antibody Arrays 74
9. The Commercial Opportunity for Microarrays 75
9.1 Market Drivers for Microarrays 75
9.2 Market Restraints for Microarrays 75
9.3 Key Players 76
9.4 Market Size, Strategic Trends and Competitive Landscape for Protein Arrays 79
9.5 Marketing and Distribution 81
9.6 Protein Arrays Market Analysis 82
9.7 Genes Associated with Major Diseases 83
9.8 Software and Data Analysis 83
9.8.1 Supplier of DNA Microarray Analysis Software 84
9.8.2 Satisfaction with Software Features 84
9.8.3 Satisfaction with Software 84
9.8.4 Supplier Factors in Software Purchase Decision 84
9.8.5 Suppliers Role in Improving Data Sharing for DNA Microarrays 84
10. Legal Aspects of Commercialization of Protein Arrays 85
11. Company Profiles 87
Appendix 1: Microarray Milestones 124
LIST OF FIGURES
Figure 5.1: Company Market Shares 41
Figure 8.1: Overall Market Size by Application, 2005 66
Figure 8.2: Source of Variation in Microarray Data 73
LIST OF TABLES
Table 3.1: Source of DNA Microarrays in Research Use 17
Table 3.2: Microarray Market Drivers 17
Table 3.3: Microarray Market Barriers 18
Table 3.4: Unit Pricing of DNA Microarrays, 2000-2010 18
Table 3.5: Steps in the Design and Implementation of a DNA Microarray Experiment 20
Table 3.6: The Main Features of Some Hybridization Microarray Formats Currently Available 21
Table 3.7: Microarray Applications 24
Table 3.8: List of DNA Array Manufacturers 26
Table 4.1: Critical Factors for Microarray Content 33
Table 4.2: Top Three Suppliers of Treated Protein Microarray Surfaces for Self-Printing 40
Table 4.3: Top Suppliers of Commercially Available Protein Microarrays 40
Table 4.4: Top Suppliers of Protein Microarray Readers 40
Table 5.1: Affymetrix Sales of Probe Arrays, 2000-2005 42
Table 5.2: Affymetrix Total Product Sales, 1999-2005 42
Table 5.3: Affymetrix Instrument Sales, 2000-2005 42
Table 6.1: Microarray Genetic Testing 54
Table 6.2: ChIP-on-Chip Microarray Market Size Projections, 2005-2011 57
Table 8.1: Applications of Biochips by Class 65
Table 8.2: Diagnostics Microarray Market Size Projections, 2005-2011 66
Table 8.3: HTS Microarray Market Size Projections, 2005-2011 66
Table 8.4: Pharmacogenomics Microarray Market Size Projections, 2005-2011 67
Table 8.5: Toxicology Screening Microarray Market Size Projections, 2005-2011 67
Table 8.6: Expression Profiling Microarray Market Size Projections, 2005-2011 67
Table 9.1: Market Share of Microarray Products, 2004 76
Table 9.2: Affymetrix Product Sales 77
Table 9.3: Agilents Net Revenue by Business Segment, 2002, 2003 and 2004 77
Table 9.4: Leading Microarray Companies 78
Table 9.5: Worldwide Microarray Market Size, 2004-2011 79
Table 9.6: Microarray Market Share by Technology Type 79
Table 9.7: DNA Microarray U.S. Market Size, 2005-2011 80
Table 9.8: DNA Microarray Worldwide Market Size, 2002-2011 80
Table 9.9: Biochip Market by Usage, 2003 and 2007 80
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