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Purinergic Signalling in Neuron-Glia Interactions, No. 276
John Wiley and Sons Ltd, April 2006, Pages: 302
ATP, the intracellular energy source, is also an extremely important cell-cell signalling molecule for a wide variety of cells across evolutionarily diverse organisms. The extracellular biochemistry of ATP and its derivatives is complex, and the large number of membrane receptors that they activate are linked to many intracellular signalling systems. Purinergic signalling affects a diverse range of cellular phenomena, including ion channel function, cytoskeletal dynamics, gene expression, secretion, cell proliferation, differentiation and cell death. Recently, this class of signalling molecules and receptors has been found to mediate communication between neurons and non-neuronal cells (glia) in the central and peripheral nervous systems. Glia are critical for normal brain function, development and response to injury. It is now clear that neural impulse activity is detected by glia and purinergic signalling is emerging as a major means of integrating functional activity between neurons, glia and vascular cells in the nervous system. These interactions mediate effects of neural activity on development of the nervous system and in association with injury, neurodegeneration, myelination and cancer. This book brings together contributions from experts in several fields, including glial biologists, neurobiologists and specialists in purinergic receptor structure and pharmacology, to consider how extracellular ATP acts to integrate communication between different types of glia, and between neurons and glia. It opens with overviews of the evolution and differentiation of glia and of purinergic signalling, and continues with detailed coverage of purine release, receptors and reagents, purinergic signalling in the neural control of glial development, glial involvement in information processing, and discussion of the interactions between neurons and microglia.
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