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Drug Discovery--European Advances in Genomics and Proteomics (Technical Insights)
Frost & Sullivan, Dec 2004
Genomics and Proteomics Research in Europe is Thriving
The European Union (EU) has become a popular hub for advanced research into genomics and proteomics. This can be attributed to the significant government funding at both the national level and from individual EU agencies. Moreover, Europe houses some of the largest pharmaceutical companies that are extending their support to research programs related to genomics and proteomics, either in-house or in collaboration with smaller firms. The primary goal is to go beyond the realms of human genome sequencing and expand the list of identified proteins and genes, which will ultimately aid in understanding disease mechanisms and developing corresponding therapeutics.
This Technical Insights research service analyses key developments in proteomics and genomics and its impact on the field of drug discovery and development. In addition to evaluating research trends in companies and universities in the EU, this study evaluates the important technology drivers and challenges. Participants can use this research service to identify potential collaborators, stay ahead of the competition and remain abreast of critical developments.
Genomics and Proteomics Gaining Prominence as Primary Tools for Drug Discovery
While the potential of genomics and proteomics is constantly growing, the most lucrative applications lie in the field of drug discovery and development and molecular diagnostics. Proteomics and genomics are expected to be key tools in target identification and validation and ultimately expanding the list of cellular targets. New information on the molecular mechanisms responsible for disease has enhanced the identification and validation processes, says the analyst of this research. With regard to molecular diagnostics, the expectation is that diseases with a genetic component can be treated according to specific genetic markers, medications and dosages that are optimized for individual patients.
Human genomic research is accelerating as scientists seek effective therapies with the ability to target the appropriate genes for activation inhibition or replacement. The target genes are multiplying in numbers and researchers are hoping to develop treatments for a wide variety of disorders, from cystic fibrosis to cancer and cardiovascular disease.
Enabling Technologies are Accelerating Progress in Genomics and Proteomics
Emerging technologies such as microarrays, automation and robotics are taking genomics and proteomics research to new heights. Weeks, if not months, were initially required to elucidate the expression of a single gene, observes the analyst. Now, tens and thousands of genes can be studied in a single afternoon. In addition, previously time-consuming and skill-intensive assays and preparations can now be accomplished thousands of samples at a time and within a few hours. This is made possible through new computer-modelling approaches such as molecular dynamics (MD), ligand docking (LD), pharmacophore modelling (PM), homology modelling (HM) and enzyme-substrate modelling (ESM).
Since conventional technologies such as 2D gel electrophoresis pose certain limitations, development of new technologies such as isotope coded affinity tags, 2D chromatographic separation, terahertz pulsed imaging (TPI) and terahertz pulsed spectroscopy (TPS) and protein arrays are also gaining importance.
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