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World Proteomics Automation Markets
Frost & Sullivan, June 2003
Standardization of Interfaces to Facilitate Automation of Proteomics
The appeal of automating proteomics methods is being somewhat diminished by technical challenges relating to integration of equipment and data. The need to combine methods for varied and complex samples creates the problem of interfacing processes that are not easily merged. Standardization of interfaces is expected to eliminate such incompatibilities and do away with the dilemma of launching a technology at the expense of an existing one. Vendors are beginning to address these challenges as the market develops and the next generation of products is introduced.
This Frost & Sullivan research examines the World Proteomics Automation Markets. It offers revenue forecasts by market segments and covers key drivers and restraints affecting market growth. It also provides strategic recommendations to overcome market challenges. This report focuses on modular automation products and the integrated systems bundled from these devices.
Proteomics Methods' Proven Success Boosts Adoption
The typical proteomics approach of 2-D gel electrophoresis (2DGE) and mass spectrometry (MS) is being acknowledged as the method of choice for separating proteins and identifying subsets, states the analyst. However, advances in other technologies have led the market to believe that complementary technologies will be used for alternative separation steps such as multi-dimensional liquid chromatography and protein chips/arrays. Reagents for differential isotope labeling have also been formulated and are expected to develop.
Despite the optimism triggered by these advances and complaints about 2DGE's time and procedural constrains, it is still the most common method for resolving thousands of proteins before the subsequent analysis. End users are more likely to automate their existing 2DGE-MS process than invest in new technologies since the others have not been as successful on a wide range of samples. Apart from separating proteins, the 2DGE approach also enables archiving of intact proteins and provides the best resolution.
Research Activities to Receive Boost from Technological Improvements
Since the recently completed Human Genome Project (HGP) has made sequence data widely available, it is now easier to identify proteins using mass spectrometry data. The refinement of 2DGE methods, improvements in bioinformatics software, and technological advances that enable reproducible automation of these processes have helped augment biological knowledge. Collaborations between groups, regardless of industry or academia status, will also increase success rates in proteomics research activities.
There is a need to combine forces with companies having complementary expertise and/or products due to the complexity of proteins and the difficulty of acquiring multi-disciplinary talent in-house, notes the analyst. Since large amounts of data are unnecessary if not for use in a biological context, the ideal partnership will be between a company having large-scale technology needing refinement and a highly specialized drug or biology-oriented research group.
Additional Information
The following technologies are covered in this research:
Integrated Systems: Integrated systems are defined as end-to-end systems providing at a minimum, the separation and mass spectrometry steps; typically, several sample preparation steps are also automated. Multi-dimensional liquid chromatography systems sold with mass spectrometers are also included within this segment, as are other proprietary systems such as integrated SELDI products.
Modular Products: Modular products are defined as standalone products, which automate one or a few of the several procedures involved in the standard gel electrophoresis and mass spectrometry proteomics approach. These can include pre-fractionation, casting, running, staining, and imaging gels as well as excising and digesting spots/fractions, spotting MALDI targets, interfacing to electrospray ionization, and other sample preparation procedures. There is some inevitable overlap within these individual product segments.
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