How do you define bioinformatics? Bioinformatics for everyone Bioinformatics - the next generation Bioinformatics - the customer need The third hurdle
II Technology and Market Analysis in Bioinformatics Scope
Introduction - Gene discovery - Internet security - Protein structure determination Background and technologies in bioinformatics - Aligning sequences - Local versus global alignments - Computing alignments - DotPlots - Dynamic programming methods - Scoring matrices - Aligning DNA sequences to protein sequences - Statistics - Multiple sequence alignments - Progressive pair-wise alignments - Profile analysis - Hidden Markov Models (HMMs)
Bioinformatics databases
Nucleotide databases - European Molecular Biology Laboratory (EMBL) - NCBI/GenBank Database - DNA Database of Japan (DDBJ)
Protein databases - SWISSPROT - TrEMBL - Protein Information Resource (PIR) - Protein Data Bank (PDB) - PROSITE - IMGT/LIGM-DB
Other major bioinformatics resources - Ensembl - Expert Protein Analysis System (ExPASy) - The Genome Database (GDB) - Human Genome Project Working Draft - The Institute for Genomic Research (TIGR) - The Jackson Laboratory (Mouse Genome Informatics) - National Center for Biotechnology Information (NCBI) - National Center for Genome Resources (NCGR) - The National Human Genome Research Institute (NHGRI) - The Sanger Center - Sequence Retrieval System (SRS) - The SNP Consortium
Methodologies for searching databases - Smith & Waterman type searches - FASTA - BLAST (Basic Local Alignment Search Tool)
Bioinformatics database search and retrieval system - Complete genomes
Standardization of bioinformatics information - XML
Development of an XML bioinformatics environment - This is a direction that the bioinformatics market is taking - Biopolymer Markup Language (BIOML) - Bioinfomatics Sequence Markup Language (BSML) - Genome Annotation Markup Elements (GAME) - Pasteur Institute Software Environment (PISE) - Microarray Markup Language (MAML) - Gene Expression Markup Language (GEML™)
Sketch and current status of the bioinformatics market opportunity - The commercial outlook - The watch or the watchmaker? - The market opportunity - Carve the meat at the biological joints - The emerging market opportunity in bioinformatics - SNPs: A false peak or a fast track to success?
