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Therapeutic Vaccines: Strong Innovation But Far Away From Capitalization
Datamonitor, Dec 2003, Pages: 148
Table of Contents
Chapter 1 Executive Summary 3
Scope 3
Datamonitor’s Insight into the Therapeutic Antibodies market in 2003 3
The therapeutic vaccine market will not receive significant attention from the wider pharmaceutical industry until a product is launched and achieves significant uptake across the seven major markets 4
For companies that are totally focused on therapeutic vaccines, the only way to survive is through a strong network of partners 7
Oncology dominates the therapeutic vaccine market both in terms of commercial potential and pipeline development 9
The industry is taking two routes to market through the development of generalized and personalized vaccines. While personalized vaccines offer greater selectivity and lower side effects, generalized vaccines offer improved economies of scale. 11
Chapter 2 IDENTIFYING AND EXPLOITING FUTURE GROWTH OPPORTUNITIES 21
Key findings 21
Introduction 22
Drivers of therapeutic vaccine innovation 22
Therapeutic strategy – targeting oncology 23
Target discovery – greater understanding through use of genomics 27
Antigen selection – from single to multiple and native to synthetic 29
Personalized vs generalized vaccine development 31
Vaccine design – from naked to encapsulated forms 37
Optimizing efficacy – adjuncts to maximize immune response 38
Therapeutic vaccine business model evolution 40
Is focusing 100% on therapeutic vaccines a sustainable business model? 40
From early drug development to full integration 44
Alliance networks are essential for innovative therapeutic vaccine players to survive 47
Late stage pipeline analysis 47
Drivers and resistors of collaborating on the development and marketing of therapeutic vaccines 48
Drivers of collaborations 49
Resistors to partnering 51
Large pharma involvement 54
Merger and acquisitions – a strategy for growth? 56
M&A for horizontal integration 57
M&A for vertical integration 58
M&A for survival 58
Chapter 3 MARKET ANALYSIS, 2002-08 59
Key findings 59
Therapeutic vaccine market size, 2002 60
Therapeutic vaccine market to 2008 61
Scenario forecasts 62
Most likely scenario, year-on-year forecasts, 2002-08 66
Shape of the therapeutic vaccine pipeline 67
Therapeutic analysis – oncology dominates the late stage and full pipeline of therapeutic vaccines 68
High unmet need and the mechanism of action of therapeutic vaccines has driven the interest in cancer indications 69
Chapter 4 THERAPEUTIC VACCINE COMPANY ANALYSIS 71
Key findings 71
Benchmarking the leading players 72
Antigenics 77
Key findings 77
Company strategy 77
Technology platform 82
Portfolio and pipeline analysis 84
Aphton 88
Key findings 88
Company strategy 88
Technology platform 92
Portfolio and pipeline analysis 94
Biomira 97
Key findings 97
Company strategy 97
Technology platform 101
Portfolio and pipeline analysis 103
Corixa 107
Key findings 107
Company strategy 107
Technology platform 114
Portfolio and pipeline analysis 116
Dendreon 122
Key findings 122
Company strategy 123
Technology platform 127
Portfolio and pipeline analysis 129
Therion Biologics 135
Key findings 135
Company strategy 135
Technology platform 139
Portfolio and pipeline analysis 141
Chapter 5 APPENDIX 145
Report methodology 145
Exchange rates 145
About Datamonitor 145
About Datamonitor Healthcare 146
Datamonitor Healthcare’s research and analysis methodologies 146
Datamonitor Healthcare’s therapy area capabilities 147
Datamonitor’s Competitive Intelligence Business Unit 148
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