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Phosphatases: Emerging Role in Signal Transduction, Human Therapeutics, & As Drug Targets
Drug and Market Development Publishing, Feb 2004
1 Executive Summary 2 Introduction and Background 3 Phosphatases in Signal TransductionClassification of Phosphatases Serine and Threonine Specific Phoaphatases PP1 and PP2A PP2B PP2C Protein Tyrosine Phosphatases (PTP)- PTPs in Signaling - PTP1B - Phosphatases in Insulin Signaling - LAR, RPTP_, - Other Phosphatases - RPTP_ - SH2 Phosphatases: SHP-1, SHP-2 - RPTPe - TCPTP - HePTP 4 Phosphatases Associated with DiseasePTP in Immune System PTP in Infectious Diseases PTP in Vascular Leakage PTPs in Osteoporosis PTPs in Apoptosis Phosphatases in Cancer PTEN MAPK Phosphatases in Diabetes and Obesity PRL-3 CDC25 MKP-1 PP2A Phosphatases in Alzheimer's Disease Small Molecule Inhibitors of Serine/Threonine Phosphatases Cantharidin Anhydride Modifications Multiple Modifications 5 Commercial Opportunity and Legal Aspects of Commercialization 6 Structural Challenges in Developing Anti-PTP Molecules 7 Literature and Latest News on Phosphatases 8 Intellectual Property Landscape for Phosphatases and Their Inhibitors 9 Companies Providing Reagents and Assays for the Phosphatase Space 10 Interviews with Industry ExpertsDr. Rob Hooft, Principal Scientist, Serono Paul G. Abrams, M.D., J.D., Ceptyr James Wells, Ph.D., President, Sunesis Christopher Lipinski, Ph.D., Roche 11 Company Profiles- Ceptyr - ISI Pharmaceuticals - Serono Pharmaceuticals - Sunesis - Vertex Pharmaceutical
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