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Drug Targets for Breast Cancer
Informa Healthcare, Jan 2006, Pages: 170
Chapter 1: Executive Summary
Breast Cancer Therapeutics
Breast Cancer Technologies
Breast Cancer Markets
The Future and Breast Cancer
Chapter 2: The Need for Breast Cancer Therapeutics
Epidemiology
Breast Cancer Types and Stages
Causes and Risk Factors
Biomarkers and Diagnostics
Awareness and Education
Treatment Strategies
Objectives and Scope
Chapter 3: Targets and Therapeutics in Endocrine Therapy
Estrogen and the Estrogen Receptor
Normal Estrogen Function
The Estrogen Receptor
Estrogen, The Estrogen Receptor, and Breast Cancer
Estrogen and Breast Cancer
The Estrogen Receptor and Breast Cancer
Categories of Endocrine Therapy
Selective Estrogen Receptor Modulators (SERMs
Mode of Action of SERMs
Approved SERMs
Emerging SERMs
Raloxifene
Arzoxifene
Lasofoxifene9
Selective Estrogen Receptor Downregulators (SERDs)
Mode of Action of SERDs
Approved SERDs
Aromatase Inhibitors
Mode of Action of Aromatase Inhibitors
Approved Aromatase Inhibitors
Emerging Aromatase Inhibitors
LHRH Agonists
Mode of Action of LHRH Agonists
Approved LHRH Agonists
Chapter 4: Innovative Therapy for Breast Cancer
Targeting Growth Factors
The erbB Receptor Family
erbB1/EGFR
erbB2/EGFR2/HER2
Targeting Growth Factors (IGF)
Targeting Angiogenesis
Vascular Endothelial Growth Factor (VEGF)
Targeting Farnesylation
Targeting the MEK Pathway
Targeting the mTOR Pathway
Targeting Apoptosis
Targeting DNA Synthesis and Repair
Targeting the Proteasome
Chapter 5: Immunotherapy for Breast Cancer
Cancer Vaccines and Breast Cancer
Current Approaches in Cancer Vaccine Development
Approved and Emerging Cancer Vaccines
Approved Cancer Vaccines
Emerging Breast Cancer Vaccines Adjuvants
Approved and Emerging Monoclonal Antibodies
Categories of Monoclonal Antibodies
Naked Monoclonal Antibodies
Conjugated Monoclonal Antibodies
Approved and Emerging Monoclonal Antibodies
Approved Monoclonal Antibodies
Emerging Monoclonal Antibodies
Chapter 6: Chemotherapy for Breast Cancer
Historical Timeline
Chemotherapy Categorization
Antimetabolites
Mitotic Inhibitors
Alkylating Agents
Anthracyclines
Topoisomerase II Inhibitors
Approved Chemotherapy Drugs for Breast Cancer
Emerging Chemotherapy Drugs for Breast Cancer
Combination Chemotherapy
Chapter 7: Technology and Breast Cancer
Gene Cloning and Characterization
Gene Expression Profiling
Proteomics
RNAi
Bioinformatics
Population Genetics
Biomarkers
Diagnostics and Prognosis
Chapter 8: The Breast Cancer Market
Endocrine Therapies
Selective Estrogen Receptor Modulators (SERMs)
Selective Estrogen Receptor Downregulators (SERDs)
Aromatase Inhibitors
Arimidex®
Femara®
Aromasin®
Luteinizing Hormone-Releasing Hormone Analogs (LHRH Analogs)
Innovative Therapies
Immunotherapies
The Chemotherapy Market
Chapter 9: Future Perspectives
Therapeutic Potential
Market Potential
Breast Cancer Treatment and the Future
Breast Cancer and the Patient
Summary
Chapter 10: Expert Interviews
James D. Winkler, Ph.D., Senior Director, Discovery Biology, Array BioPharma
Dr. George Blackledge, Senior Oncology Physician, AstraZeneca
Dr. Rene Bernards, Chief Scientific Officer, Agendia
Dr. Thomas J. Schuetz, Chief Medical Officer and Senior VP of Medical Affairs,
Therion Biologics
Chapter 11: Company Profiles
Aeterna Zentaris Inc
Agendia BV
American Pharmaceutical Partners, Inc
Array BioPharma Inc
AstraZeneca plc
Bristol Myers Squibb
Dendreon Corporation
Eli Lilly and Company
Genentech, Inc
Genta, Inc.
Igeneon
Novartis AG
Sanofi-aventis
Therion Biologics Corporation
ViRexx Medical Corp
Chapter 12: References
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