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The Biology of Extracellular Molecular Chaperones
John Wiley and Sons Ltd, March 2008, Pages: 248
Symposium on The biology of extracellular molecular chaperones, held at the Novartis
Foundation, London, 5–7 June 2007
Editors: Derek J. Chadwick (Organizer) and Jamie Goode
This symposium is based on a proposal made by Brian Henderson, R. John Ellis and A. Graham Pockley
Péter Csermely Chair’s introduction 1
Jodie Haak and Kevin C. Kregel 1962–2007: a cell stress odyssey 3
Discussion 15
Peter A. Lund and R. John Ellis The chaperone function:
meanings and myths 23
Discussion 36
Péter Csermely, Tamás Korcsmáros, István A. Kovács,
Máté S. Szalay and Csaba Soti Systems biology of molecular
chaperone networks 45
Discussion 54
Radhey S. Gupta , Nallur B. Ramachandra, Timothy Bowes and
Bhag Singh Unusual cellular disposition of the mitochondrial
molecular chaperones Hsp60, Hsp70 and Hsp10 59
Discussion 69
Martha Triantafilou, Daniel Sawyer, Abdiaziz Nor,
Emmanouil Vakakis and Kathy Triantafilou Cell surface
molecular chaperones as endogenous modulators of the innate
immune response 74
Discussion 79
A. Graham Pockley and Gabriele Multhoff Cell stress proteins in
extracellular fluids: friend or foe? 86
Discussion 96
Francisco J. Quintana and Irun R. Cohen HSP60 speaks to the immune
system in many voices 101
Discussion 111
Stuart K. Calderwood, Jianlin Gong, Jimmy R. Theriault,
Salamatu S. Mambula and Philip J. Gray Jnr Cell stress proteins:
novel immunotherapeutics 115
Discussion 131
General discussion 137
Brian Henderson Cell stress proteins as modulators of bacteria–host
interactions 141
Discussion 154
Anthony R. M. Coates, Ana Cehovin and Yanmin Hu Chaperonin 60 and
macrophage activation 160
Discussion 169
Alexzander Asea Hsp70: a chaperokine 173
Discussion 179
Hajime Nakamura Extracellular functions of thioredoxin 184
Discussion 192
Carol L. Miller-Graziano, Asit De, Krzysztof Laudanski,
Tara Herrmann and Sanjukta Bandyopadhyay HSP27: an
anti-inflammatory and immunomodulatory stress protein acting to
dampen immune function 196
Discussion 208
Gabriel S. Panayi and Valerie M. Corrigall BiP, an anti-inflammatory
ER protein, is a potential new therapy for the treatment of rheumatoid
arthritis 212
Discussion 216
Final discussion 221
Index of contributors 225
Subject index 227
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