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Treating COPD Comorbidities: A Market Opportunity for Systemic Anti-Inflammatory Agents?
Decision Resources, Inc., March 2008, Pages: 42
Executive Summary Strategic Considerations Stakeholder Implications Introduction Understanding the Mechanisms of COPD Risk Factors for COPD Pathophysiology of COPD Small Airway Disease Emphysema Role of Systemic Inflammation in COPD Comorbidities Associated with COPD Caused by Systemic Inflammation Cardiovascular Complications: Atherosclerosis and Pulmonary Arterial Hypertension Atherosclerosis Pulmonary Arterial Hypertension Osteoporosis Type 2 Diabetes Cachexia Drug Classes with Possible Use in Treating the Systemic and Localized Infl ammation of COPD TNF-a Inhibitors PPAR-Gamma Agonists Statins PDE Inhibitors Assessing the Unanswered Questions About Treating Systemic Inflammation in COPD Appendix:Current Treatments for Localized COPD Short-Acting Beta2 Agonists Long-Acting Beta2 Agonists Muscarinic Antagonists Inhaled Corticosteroids Beta2 Agonist/Muscarinic Antagonist Combinations Long-Acting Beta2 Agonist/Inhaled Corticosteroid Combinations Methylxanthines
Tables: 1. Sales of Leading Agents to Treat COPD, 2006 2. Risk Factors Linked to COPD 3. Inflammatory Molecules Involved in COPD 4. Existing and Emerging TNF-a Inhibitors, 2008 5. Existing and Emerging PPAR-Gamma Agonists, 2008 6. Approved Statins, 2008 7. Approved and Emerging PDE 4 and 5 Inhibitors, 2008
Figures: 1. Prevalent Cases of COPD in the United States, Europe, and Japan, 2006 and 2011 2. Comorbidities Associated with COPD
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