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Pulmonary Arterial Hypertension: Diagnosis and Evidence-Based Treatment
John Wiley and Sons Ltd, May 2008, Pages: 272
Preface
Contributors
1 Introduction
Robyn J. Barst
2 Diagnosis and assessment of pulmonary arterial hypertension
Michael D. McGoon, Adam Torbicki and Ronald J. Oudiz
2.1 Hemodynamics of pulmonary hypertension
2.2 Venice classification
2.3 Overview of the diagnostic process (algorithm)
2.4 Screening (identifying a pre-existing risk)
2.5 Detection (discovering pulmonary hypertension)
2.6 Definition (diagnosing the clinical context)
2.7 Prediction (estimating prognosis)
2.8 Principles of follow-up (evaluating and responding to outcome)
2.9 Specific tests in the evaluation of pulmonary hypertension
3 Conventional therapy in pulmonary arterial hypertension
Richard N. Channick
3.1 Calcium channel antagonists
3.2 Diuretics
3.3 Warfarin
3.4 Supplemental oxygen
3.5 Inotropic therapy
3.6 General measures
3.7 Conclusions
4 Prostanoid treatment for pulmonary arterial hypertension
Olivier Sitbon and Gérald Simonneau
4.1 Epoprostenol
4.2 Treprostinil
4.3 Iloprost
4.4 Beraprost
4.5 Treatment selection
4.6 Conclusions
5 Endothelin receptor antagonists in pulmonary arterial
hypertension
David B. Badesch and Marc Humbert
5.1 Bosentan
5.2 Sitaxsentan
5.3 Ambrisentan
5.4 Safety and tolerability with endothelin receptor antagonists
5.5 Conclusions
6 Phosphodiesterase-5 inhibitors in pulmonary arterial hypertension
Hossein A. Ghofrani, Werner Seeger and Friedrich Grimminger
6.1 The origins of phosphodiesterase-5 inhibitor development
6.2 Pulmonary hypertension as a new indication for phosphodiesterase-5 inhibitor treatment
6.3 Role of phosphodiesterase-5 in the pulmonary vasculature
6.4 Clinical experience with sildenafil for the treatment of chronic pulmonary hypertension
6.5 Pivotal trial and approval of sildenafil for the treatment of pulmonary arterial hypertension (SUPER-1 study)
6.6 Other phosphodiesterase-5 inhibitors
6.7 Combination therapy
6.8 Potential new indications for phosphodiesterase-5 inhibitors outside pulmonary arterial hypertension
6.9 Conclusions
7 Combination therapy for pulmonary arterial hypertension
Anne Keogh and Marius Hoeper
7.1 Background
7.2 Combination therapy to date
7.3 Conclusions
8 Interventional and surgical modalities of treatment for pulmonary arterial hypertension
Julio Sandoval and Ramona Doyle
8.1 Introduction
8.2 Atrial septostomy
8.3 Pulmonary endarterectomy in chronic thromboembolic pulmonary hypertension
8.4 Lung transplantation for pulmonary hypertension
8.5 Conclusions
9 End points and clinical trial design in pulmonary arterial hypertension: Clinical and regulatory perspectives
Andrew J. Peacock
9.1 Introduction
9.2 Trial design
9.3 End points in trials of therapy for pulmonary arterial hypertension
9.4 Conclusions
10 Comparative analysis of clinical trials and evidence-based treatment algorithm for pulmonary arterial hypertension
Nazzareno Galiè, Alessandra Manes, Naushad Hirani and Robert Naeije
10.1 Introduction
10.2 Randomized controlled studies
10.3 Long-term continuation studies
10.4 Combination studies
10.5 Evidence-based treatment algorithm
10.6 Conclusions
11 Diagnosis and assessment of non-pulmonary arterial hypertension masquerading as idiopathic pulmonary arterial hypertension: Diastolic heart failure - evaluation and interactions
Mardi Gomberg-Maitland and Stuart Rich
11.1 Definition of heart failure
11.2 Epidemiology
11.3 Physiology
11.4 Evaluation of diastolic heart failure: Invasive and noninvasive techniques
11.5 Diagnosis and treatment of diastolic dysfunction
11.6 Pulmonary hypertension and diastolic dysfunction
11.7 Conclusions
12 Treatment of pulmonary arterial hypertension: A look to the future
Lewis J. Rubin
12.1 Therapy of pulmonary arterial hypertension
12.2 Measuring outcomes and monitoring the course of therapy
12.3 Conclusions
Index
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