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DNA Interactions with Polymers and Surfactants
John Wiley and Sons Ltd, May 2008, Pages: 408
This report provides discussion of the ways that DNA may be mixed or dissolved in a solution to achieve the best results in causing DNA to be delivered and absorbed. This has great biological implications in that we can deliver healthy DNA to cells, allowing them to produce their own therapeutic proteins. For more than 20 years, researchers have been working to alleviate disease through this kind of gene therapy. Recent successes occur mostly in treating hemophilia, but there is growing potential for treatment of other genetic diseases and conditions. Specifically the book will address solutions in which DNA can be mixed to achieve delivery and absorption into cells. The book will provide a broad overview of interaction of DNA with solutions, with an emphasis on inorganic metal ions, organic cations, positively charged polymers, proteins and surfactants and lipids. The interactions in both bulk solution and at interfaces are covered.
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