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Targeted Diagnostic Imaging Agents
Greystone Associates, July 2007, Pages: 160
Driven by advances in molecular probe design and biomarker detection methodologies, new imaging agents that can improve visualization of pathologies and cellular processes are changing the practice of diagnostic medicine. The ability of this new generation of contrast agents to detect metabolic changes at the molecular level has significant potential for improving visualization and quality of care. Targetable and activatable imaging agents are gaining interest for a wide range of diagnostic applications that include cardiology, neurology and soft tissue tumor detection. The number of healthcare conditions that can be effectively imaged noninvasively is expanding as a result of these innovative detection technologies. Targeted and activatable imaging agents offer a unique capability to generate unambiguous images by exploiting specific molecular targets, pathways or cellular processes. This new wave of imaging agents signals a paradigm shift in which the reagents take on new importance alongside system hardware in revenue projections and product line ROI.
Diagnostic Imaging Agents: The Next
Generation is a comprehensive evaluation and analysis of the technology, products and participants providing the driving force behind this growing segment of the diagnostics sector. Published in July (2007), the report has been designed and developed to provide pharmaceutical company decision makers, enabling technology providers, discovery tool designers, and industry strategists with a detailed understanding of the expanding role and potential of biomarker discovery on drug development and diagnostic medicine. Provider organization business managers, healthcare administrators and investors will also benefit from this publication. Imaging Processes at the Molecular and Cellular Level A number of challenging opportunities are on the horizon for medical imaging. Unlike many other sectors of the healthcare industry where technology successes periodical occur that seem to propel the market forward, these opportunities are being driven by the migratory advances of academic, public (government) and commercial research programs.
The potential for the next generation of diagnostic imaging agents is significant. SPECT and PET tracers have been developed to measure oxidative metabolism, fatty acid and amino acid metabolism, and pre- and post-synaptic receptor densities. The ability of these first-generation agents to improve diagnostic and treatment capabilities is now driving a directed effort to develop the next-generation of molecular agents. To sense biological processes such as gene expression, angiogenesis, apoptosis or cell trafficking in vivo, imaging reporter agents that interact specifically with molecular targets and appropriate imaging systems are currently under development.
Molecular imaging will greatly reduce the need for animal tissue sampling or human biopsy when studying the progression of a disease or the follow-up of a gene therapy. It has the advantage of being non-invasive, and because it can be repeated many times, it provides both spatial and temporal dimensions to the understanding of the gene expression of the disease or therapy.
Market Data
The study presents qualitative and quantitative data and information on key market measures and benchmarks:
- Imaging Segment Assessment
- Commercial Limitations
- Global Market Analysis
- Company Profiles
- Technology Assessments
- Alliances and Strategies
- Commercialization Strategies
- Regulatory Factors
- Imaging Agent Development Criteria
- Technology Risk Factors
Methodology
Research methodology is based on primary research in the form of in-depth interviews with key market participants, technology developers, distributors, industry experts, and market influencers, a list that includes regulatory officials, industry trade groups, and materials standards organizations.
Primary data is evaluated and normalized against secondary sources including trade journal articles, technical literature, industry publications, company data sheets and published information, and statistical data from government agencies and trade associations.
Forecasts and projections of market demand and future market activity are derived using standard modeling and statistical techniques
Feature Summary
- Analyzes and assesses emerging imaging diagnostic candidates, their capabilities, benefits, limitations and potential
- Profiles development-stage imaging agents and examines their clinical status and commercial prospects
- Analyzes key industry alliances and partnerships by imaging modality, and examines the impact of next-generation imaging candidates on future imaging markets
- Profiles market participants, their development activity and business strategies
- Evaluates the impact of economic, technology, and regulatory factors on the development and commercialization of emerging imaging agents
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