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Pharmacology for the Health Care Professions
John Wiley and Sons Ltd, Oct 2008, Pages: 376
Contents
Foreword xiii
Preface xv
Acknowledgements xvii
1 Introduction 1
1.1 Pharmacology and health care professionals 2
1.2 Patient compliance 4
1.3 Drug names 4
Part I Principles of pharmacology 7
2 Drug disposition 9
2.1 Chapter overview 9
2.2 Administration of drugs 9
2.3 Absorption of drugs 13
2.4 Drug distribution 17
2.5 Drug metabolism 20
2.6 Excretion of drugs 23
2.7 Summary 26
3 Effects of drugs on the body 29
3.1 Chapter overview 29
3.2 Adverse reactions to drugs 29
3.3 Variation in response to drug therapy 36
3.4 Targets for drug action 40
3.5 Summary 45
Part II Systemic pharmacology 49
4 Cardiovascular and blood disorders 51
4.1 Cardiovascular disorders 51
4.2 Hypertension 58
4.3 Drugs used to treat cardiovascular disorders 60
4.4 Blood disorders 68
4.5 Anaemias 73
4.6 Lipid metabolism 75
4.7 Lipid-lowering drugs 77
4.8 Summary 79
5 Respiratory Disorders 85
5.1 Chapter overview 85
5.2 Asthma 88
5.3 Chronic bronchitis 88
5.4 Drugs used to treat respiratory disorders 89
5.5 Treatment of other respiratory conditions 92
5.6 Summary 94
6 Disorders of the endocrine system 99
6.1 Chapter overview 99
6.2 Pituitary gland 99
6.3 Thyroid gland 102
6.4 Parathyroid glands 104
6.5 Adrenal glands 105
6.6 Pancreas 106
6.7 Treatment of diabetes mellitus 108
6.8 Summary 111
7 Disorders of the musculoskeletal system 115
7.1 Chapter overview 115
7.2 Rheumatic diseases 115
7.3 Drugs used to treat rheumatic diseases 116
7.4 Gout 123
7.5 Drugs used to treat gout 124
7.6 Osteoarthritis 125
7.7 Paget’s disease 126
7.8 Treatment of Paget’s disease 126
7.9 Osteoporosis 127
7.10 Drugs used to treat osteoporosis 127
7.11 Osteomalacia 128
7.12 Myasthenia gravis 128
7.13 Treatment of myasthenia gravis 129
7.14 Motor neuron disease and multiple sclerosis 130
7.15 Summary 132
8 Disorders of the skin 137
8.1 Chapter overview 137
8.2 Eczema 138
8.3 Treatment of eczema 139
8.4 Psoriasis 140
8.5 Treatment of psoriasis 141
8.6 Warts 144
8.7 Treatment of warts 145
8.8 Other viral infections of the skin 146
8.9 Fungal infections of the skin and nails 146
8.10 Drugs used to treat fungal infection of the skin and nails 147
8.11 Bacterial infection of the skin 150
8.12 Summary 151
9 Chemotherapy of infectious diseases 155
9.1 Chapter overview 155
9.2 Bacteria 155
9.3 Antibiotic drugs 157
9.4 Treatment of tuberculosis 160
9.5 Viruses 161
9.6 Antiviral drugs 162
9.7 Treatment of HIV infection 165
9.8 Fungi 165
9.9 Antifungal drugs 166
9.10 Protozoa 168
9.11 Antimalarial drugs 169
9.12 Drugs for toxoplasma and pneumocystis pneumonia 170
9.13 Parasitic worms 170
9.14 Anthelmintics 172
9.15 Summary 173
10 Cancer chemotherapy 177
10.1 Chapter overview 177
10.2 Biology of cancer 177
10.3 Principles of chemotherapy 180
10.4 Drugs used in cancer chemotherapy 182
10.5 Summary 188
11 Disorders of the central nervous system 191
11.1 Chapter overview 191
11.2 Affective disorders 194
11.3 Drugs used to treat depression 198
11.4 Drugs used to treat bipolar depression and mania 200
11.5 Psychoses 201
11.6 Drugs used to treat schizophrenia 203
11.7 Anxiety and insomnia 205
11.8 Anxiolytics and hypnotics 207
11.9 Treatment of anxiety 207
11.10 Treatment of insomnia 209
11.11 Attention deficit hyperactivity disorder (ADHD) 210
11.12 Treatment of ADHD 211
11.13 Parkinson’s disease 211
11.14 Drugs used to treat Parkinson’s disease 213
11.15 Epilepsy 216
11.16 Drugs used to treat epilepsy 217
11.17 Alzheimer’s disease 221
11.18 Treatment of Alzheimer’s disease 221
11.19 Summary 221
12 Anaesthesia and analgesia 229
12.1 Chapter overview 229
12.2 General anaesthesia 229
12.3 Inhalation anaesthetics 231
12.4 Intravenous anaesthetics 232
12.5 Premedication and adjuncts to general anaesthesia 234
12.6 Local anaesthesia 236
12.7 Local anaesthetics 241
12.8 Analgesia 243
12.9 Peripherally acting analgesics 244
12.10 Centrally acting analgesics 247
12.11 Neuropathic pain 247
12.12 Summary 248
13 Contrast agents and adjuncts to radiography 253
13.1 Chapter overview 253
13.2 Contrast agents 253
13.3 Cautions in use of contrast agents 257
13.4 Complications of intravenous administration of contrast agents 257
13.5 Adverse reactions to contrast agents 257
13.6 Management of acute adverse reactions to contrast agents 259
13.7 Adjuncts to radiography 260
13.8 Summary 264
Part III Prescribing and the law 269
14 Medicines, the law and health care professionals 271
14.1 Chapter overview 271
14.2 Legislation 271
14.3 Non-medical prescribing 279
14.4 Summary 284
15 Prescribing in practice 291
15.1 Chapter overview 291
15.2 Podiatry 291
15.3 Extension of access to prescription-only medicines in podiatry and podiatic surgery 292
15.4 Podiatry in the community 299
15.5 Radiography 300
15.6 Medicines in radiography: prescription, supply and administration 300
15.7 Physiotherapy 315
15.8 Summary 319
Appendices 321
Appendix A: Drug Names 323
Appendix B: Glossary 331
Appendix C: Examples of Patient Group Directions 337
Bibliography 343
Useful websites 345
Index 349
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