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Antibodies in Oncology: Drug Pipeline Update 2009
Bioseeker, Jan 2009
The commercial and therapeutic success of antibodies like Rituxan, Avastin, and Erbitux will force the industry to look into the next generation of therapeutic antibodies, preparing themselves for the second wave in the lucrative field of therapeutic antibodies. Today, there are more than 222 companies plus partners developing more than 463 antibody based oncology drugs in more than 820 developmental projects. In addition, the accumulated number of ceased drugs over the last three years amount to another 200 drugs. In all, these antibody based drugs target around 64 different cancer indications. The number of antibody targets has increased to over 195 described molecular targets in just a few years. These targets are further categorized on the CD-ROM by 40 classifications of molecular function and with pathway referals to BioCarta, KEGG and NetPath. Read more below on how the Antibody in Oncology: Drug Pipeline Update is organized.
How May Drug Pipeline Update Be of Use?
Show investors/board/management that you are right on top of drug development progress in your therapeutic area.
Find competitors, collaborations partners, M&A candidates etc.
Jump start competitive drug intelligence operations
Excellent starting point for world wide benchmarking
Compare portfolio and therapy focus with your peers
Speed up pro-active in-/out licensing strategy work
Fast and easy way of tracking drugs using search engines; just one click from inside the application and you may search the World Wide Web and PubMed for any drug.
Drug Pipeline Update is delivered to you as a CD-ROM application, which requires no installation on your computer. Please read more about application features and system requirements below.
Drug Pipeline Update at a Glance
Investigators Includes 222 principal investigators plus their collaborators. There is direct access from inside the application to web pages of all principal investigators.
Note: You are able to sort and find drugs according to investigators and partners from drop-down menus in the application. You may also sort and find drugs according to country of investigator.
Drug name & Synonyms Lists commercial, generic and code names for drugs. In all more than 700 names
Developmental stage This Drug Pipeline Update contains 463 antibody drugs in active development and 825 developmental projects:
#18 projects have reached market approval
#2 projects have been registered
#4 projects in pre-registration
#37 projects in Phase III
#213 projects in Phase II
#171 projects in Phase I
#375 projects in Preclinical
#5 projects in other developmental stages
Note: You are able to sort and find drugs according to developmental stage from drop-down menu in the application.
Indications Included antibody drugs are in development for 111 different indications, where of 64 are different cancer indications. All antibodies are in development for the treatment of cancer.
Note: You are able to sort and find drugs according to type of indication from drop-down menu in the application.
Targets Identified drugs are linked to more than 195 different targets, divided into 40 classifications of molecular function:
- Auxiliary transport protein activity
- Carboxypeptidase activity
- Catalytic activity
- Cell adhesion molecule activity
- Chaperone activity
- Chemokine activity
- Cofactor binding
- Complement activity
- Cytokine activity
- DNA topoisomerase activity
- Extracellular ligand-gated ion channel activity
- Extracellular matrix structural constituent
- G-protein coupled receptor activity
- Growth factor activity
- Hormone activity
- Hydrolase activity
- Intracellular ligand-gated ion channel activity
- Kinase binding
- Metallopeptidase activity
- MHC class I receptor activity
- Molecular function unknown
- Oxidoreductase activity
- Peptidase activity
- Peptide hormone
- Protease inhibitor activity
- Protein binding
- Protein serine/threonine kinase activity
- Receptor activity
- Receptor binding
- Receptor signaling complex scaffold activity
- Receptor signaling protein tyrosine phosphatase activity
- RNA-directed DNA polymerase activity
- Serine-type peptidase activity
- Structural constituent of cytoskeleton
- T cell receptor activity
- Translation regulator activity
- Transmembrane receptor activity
- Transmembrane receptor protein tyrosine kinase activity
- Transporter activity
- Unclassified
Identified targets are categorized into 19 different primary and alternate sub-cellular localizations:
- Centrosome
- Clathrin-coated vesicle
- Cytoplasm
- Cytoplasmic vesicle
- Cytoskeleton
- Endoplasmic reticulum
- Endosome
- Extracellular
- Extracellular matrix
- Golgi apparatus
- Integral to membrane
- Lysosome
- Mitochondrion
- Nucleolus
- Nucleus
- Perinuclear vesicle
- Plasma membrane
- Secreted
- Secretory granule
Note: You are able to sort and find drugs according to target gene name, molecular function of target, and target localization from drop-down menus in the application.
Target Expression Profile Direct links are provided from inside the application to 181 protein expression profiles of 126 drug targets in various human tissues and cancer types, cell lines and primary cells, including up to:
- 48 different normal tissue types
- 20 different types of cancer
- 47 cell lines
- 12 samples of primary blood cells
Pathway Referals Identified targets have been cross referenced against their invovlement in different cellular pathways, according to BioCarta, KEGG and NetPath.
- BioCarta 144 Pathways
- KEGG 48 Pathways
- NetPath 14 Signaling Pathways
Note: You are able to sort and find drugs according to targeted pathways from drop-down menues in the application.
Mechanism In total there are 198 different drug mechanism of action represented in this Drug Pipeline Update.
Note: You are able to sort and find drugs according to mechanism of action from drop-down menu in the application.
Compound All antibody based
Drug Profile Progress analysis and review of drug development. A typical drug profile reports on, depending on stage of development and available information:
Drug Name & Synonyms
Presentation of drug name and synonyms
Principal Investigator & Partners
Presentation of principal investigator and partners
Target and Molecular Function of Target
Described target(s) is/are presented with:
Official Gene Symbol - Official Gene Name [Species/Homo Sapiens] - Molecular Function
Target Localization
Described target(s) is/are presented with primary and alternate localizations.
Target Expression Profiles
Links to protein expression profile(s) of target(s) in various human tissues, cell lines and primary cells, including up to:
48 different normal tissue types
20 different types of cancer
47 cell lines
12 samples of primary blood cells
Targeted Pathways
Described target(s) is/are matched for the involvement in cellular pathways according to BioCarta, KEGG, and NetPath.
Mechanism
Drug mechanism of action
Developmental Projects
Summary field of developmental projects for the drug, including indication, developmental stage and status.
Example:
Cancer, myeloma - Phase II Clinical Trial - Active
Cancer, prostate - Phase III Clinical Trial - Ceased
Drug Description
Short introduction to drug
Compound Data
Compound type, Chemical name, CAS Number and molecular weight
Patent Data
Available patent information related to the drug is presented here.
Business & Markets
Collaborations and deals
Approvals and submissions
Analyst comments
Phase III Data
Available Phase III development data, developmental history and scientific data.
Phase II Data
Available Phase II development data, developmental history and scientific data.
Phase I Data
Available Phase I development data, developmental history and scientific data.
Preclinical Data
Available preclinical development data, developmental history and scientific data.
Licensing Information
Availability for licensing
Application Features Use 13 different parameters, available in drop-down menus, to find and sort among drugs
- Drug status
- Clinical Trial Status
- Principle Investigator
- Partners
- Indication
- Developmental Stage
- Compound Type
- Mechanism
- Target
- Molecular Function of Target
- Target Localization
- Targeted Pathways
- Free text search of entire drug profile contents
Direct linkage from inside the application to related internet resources
- Drug data is linked to search engines like Google and PubMed
- Drug target data is linked directly to BioCarta, Human Protein Atlas, KEGG, and NetPath
- Direct links to company web pages of principal investigators
Export and sharing of information
- Found information is easily shared with others over e-mail, file export (xls) or in print
System Requirements - AMD-Athlon/Pentium II PC
- Windows 98/NT4/2000/ME/XP/VISTA
- 8x-speed CD Rom drive
- SVGA 16 bit display. (32 bit recommended)
- 32 MB of available RAM (128 MB recommended)
- Internet access (for related internet resources)
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