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Nanobiotechnology Applications, Markets and Companies
Jain PharmaBiotech, Nov 2009, Pages: 735
Executive Summary
1. Basics of Nanobiotechnology
Introduction
Classification of nanobiotechnologies
Top-down and bottom-up approaches
Landmarks in the evolution of nanobiotechnology
Relation of nanobiotechnology to healthcare
2. Technologies
Introduction
Micro- and nano-electromechanical systems
BioMEMS
Microarrays and nanoarrays
Dip Pen Nanolithography for nanoarrays
Protein nanoarrays
Microfluidics and nanofluidics
Nanotechnology on a chip
Microfluidic chips for nanoliter volumes
Nanogen's NanoChip
Use of nanotechnology in microfluidics
Construction of nanofluidic channels
Nanoscale flow visualization
Moving (levitation) of nanofluidic drops with physical forces
Electrochemical nanofluid injection
Nanofluidics on nanopatterned surfaces
Nano-interface in a microfluidic chip
Nanofluidic channels for study of DNA
Visualization and manipulation on nanoscale
4Pi microscope
Atomic force microscopy
Basic AFM operation
Advantages of AFM
Force sensing Integrated Readout and Active Tip
Cantilever technology
CytoViva® Microscope System
Fluorescence Resonance Energy Transfer
Magnetic resonance force microscopy and nanoscale MRI
Multiple single-molecule fluorescence microscopy
Near-field scanning optical microscopy
Nano-sized light source for single cell endoscopy
Nanoparticle characterization by HaloÔ LM10 technology
Nanoscale scanning electron microscopy
Use of SEM to reconstruct 3D tissue nanostructure
Optical Imaging with a Silver Superlens
Photoactivated localization microscopy
Scanning probe microscopy
Partial wave spectroscopy
Ultra-nanocrystalline diamond
Visualizing atoms with high-resolution transmission electron microscopy
Companies that provide microscopes for nanobiotechnology
Surface plasmon resonance
Nanoparticles
Types of nanoparticles
Fluorescent nanoparticles
Gold nanoparticles
Lipoparticles
Paramagnetic and superparamagnetic nanoparticles
Quantum dots
Silica nanoparticles
Assembly of nanoparticles into micelles
Biomedical applications of self-assembly of nanoparticles
Production techniques for nanoparticles
Nanostructures
Bacterial structures relevant to nanobiotechnology
Bacterial spores
Nanostructures based on bacterial cell surface layers
Bacterial magnetic particles
Cubosomes
Dendrimers
Properties
Applications
DNA-nanoparticle conjugates
DNA octahedron
Potential applications
Fullerenes
Nanoshells
Nanotubes
Carbon nanotubes
Carbon nanotubes and DNA
Applications of nanotubes
NanoBuds
Nanowires
Nanostamping
Nanoneedles
Nanopores
Nanoporous silica aerogel
Nanostructured silicon
Networks of gold nanoparticles and bacteriophage
Polymer nanofibers
Protein-nanoparticle combination
Nanomaterials for biolabeling
DNA Nanotags
Fluorescent lanthanide nanorods
Magnetic nanotags
Molecular computational identification
Nanophosphor labels
Organic nanoparticles as biolabels
Quantum dots as labels
SERS nanotags
Silica nanoparticles for labeling antibodies
Silver nanoparticle labels
Companies providing services and products for nanobiotechnology
3. Applications in Life Sciences
Introduction
Nanotechnology and biology
NanoSystems Biology
Nanobiology and the cell
Biosensing of cellular responses
Control of T cell signaling activity
Measuring mass of single cells
Nanostructures involved in endocytosis
Nanotechnology-based live-cell single molecule assays
Quantum dots for cell labeling
Quantum dots for study of apoptosis
Single cell injection by nanolasers
Study of complex biological systems
Molecular motors
Nanomotor made of nucleic acids
phi29 DNA packaging nanomotor
Light-activated ion channel molecular machines
Application of AFM for biomolecular imaging
Future insights into biomolecular processes by AFM
4Pi microscopy to study DNA double-strand breaks
Multi-isotope imaging mass spectrometry
Applications of biomolecular computing in life sciences
Molecular electronics
Microbial nanomaterials
Use of bacteria to construct nanomachines
Bacteriophage nanoshells
Natural nanocomposites
Nanotechnology in biological research
Nanoparticles for biological research
Disguising quantum dots as proteins for cell entry
Molecular biology and nanotechnology
Structural DNA nanotechnology
Reversibly binding of gold nanospheres to DNA strands
RNA nanotechnology
Genetically engineered proteins for nanobiotechnology
Single molecule studies
Optical trapping and single-molecule fluorescence
3D single-molecular imaging by coherent X-ray diffraction imaging
Studying the molecular mechanisms of enzymes
Nanochemistry
Nanoscale pH Meter
Application of nanolasers in life sciences
Nanomanipulation
Nanomanipulation by combination of AFM and other devices
Surgery on living cells using AFM with nanoneedles
Optoelectronic tweezers
Optical manipulation of nanoparticles
Manipulation of DNA sequence by use of nanoparticles as laser light antennas
Nanomanipulation of single molecule
Fluorescence-force spectroscopy
Nanomanipulation for study of mechanism of anticancer drugs
Nanotechnology in genomic research
Use of nanotechnology for separation of DNA fragments
Nanotechnology-based DNA sequencing
Single-molecule detection of DNA hybridization
Role of nanobiotechnology in identifying single nucleotide polymorphisms
Nanobiotechnology for study of mitochondria
Nanomaterials for the study of mitochondria
Study of mitochondria with nanolaser spectroscopy
Role of nanotechnology in proteomics research
Study of proteins by atomic force microscopy
Single cell nanoprobe for studying gene expression of individual cells
Nanoproteomics
Multi Photon Detection
Nanoflow liquid chromatography
High-field asymmetric waveform ion mobility mass spectrometry
Protein nanocrystallography
QD-protein bioconjugate nanoassembly
Nanoproteomics for study of misfolded proteins
Dynamic reassembly of peptides
Use of nanotube electronic biosensor in proteomics
Nanometer photomasks from bacterial protein
Proteomics at single molecule level
Study of protein synthesis and single-molecule processes
Protein expression in individual cells at the single molecule level
Single-molecule mass spectrometry using nanotechnology
Biochips for nanoscale proteomics
Protein biochips based on fluorescence planar wave guide technology
Nanofilter array chip
Role of nanotechnology in study of membrane proteins
Nanoparticles for study of membrane proteins
Study of single protein interaction with cell membrane
Quantum dots to label cell surface proteins
Study of single membrane proteins at subnanometer resolution
Nanoparticle-protein interactions
Protein engineering on nanoscale
Nanowires for protein engineering
A nanoscale mechanism for protein engineering
Role of nanoparticles in self-assembly of proteins
Role of nanotechnology in peptide engineering
Manipulating redox systems for nanotechnology
Self-assembling peptide scaffold technology for 3-D cell culture
Nanobiotechnology and ion channels
Aquaporin water channels
Role of nanobiotechnology in engineering ion channels
Application of nanobiotechnology in molecular electronics
Nanotechnology and bioinformatics
3D nano-map of synapse
Companies providing nanotechnology for life sciences research
4. Nanomolecular Diagnostics
Introduction
Nanodiagnostics
Rationale of nanotechnology for molecular diagnostics
Nanoarrays for molecular diagnostics
NanoPro™ System
Nanofluidic/nanoarray devices to detect a single molecule of DNA
Self-assembling protein nanoarrays
Fullerene photodetectors for chemiluminescence detection on microfluidic chip
Nanofountain AFM probe
Protein microarray for detection of molecules with nanoparticles
Protein nanobiochip
Nanoparticles for molecular diagnostics
Gold nanoparticles
Quantum dots for molecular diagnostics
Quantum dots for detection of pathogenic microorganisms
Bioconjugated QDs for multiplexed profiling of biomarkers
Imaging of living tissue with quantum dots
Magnetic nanoparticles
Magnetic nanoparticles for bioscreening
Superparamagnetic nanoparticles for cell tracking
Monitoring of implanted NSCs labeled with nanoparticles
Perfluorocarbon nanoparticles to track therapeutic cells in vivo
Superparamagnetic iron oxide nanoparticles for calcium sensing
Magnetic nanoparticles for labeling molecules
Ferrofluids
Super conducting quantum interference device
Study of living cells by superparamagnetic nanoparticles
Use of nanocrystals in immunohistochemistry
Imaging applications of nanoparticles
Dendritic nanoprobes for imaging of angiogenesis
Gadolinium-loaded dendrimer nanoparticles for tumor-specific MRI
Gadonanotubes for MRI
Gold nanorods and nanoparticles as imaging agents
In vivo imaging using nanoparticles
Manganese oxide nanoparticles as contrast agent for brain MRI
Nanoparticles vs microparticles for cellular imaging
Nanoparticles as contrast agent for MRI
Quantum dots for biological imaging
Superparamagnetic nanoparticles combined with MRI
Concluding remarks and future prospects of nanoparticles for imaging
Study of chromosomes by atomic force microscopy
Applications of nanopore technology for molecular diagnostics
Nanopore technology for detection of single DNA molecules
Nanocytometry
Simultaneous detection of DNA and proteins
DNA-protein and -nanoparticle conjugates
Resonance Light Scattering technology
DNA nanomachines for molecular diagnostics
Nanobarcodes technology
Nanobarcode particle technology for SNP genotyping
Qdot nanobarcode for multiplexed gene expression profiling
Biobarcode assay for proteins
Single-molecule barcoding system for DNA analysis
Nanoparticle-based colorimetric DNA detection method
SNP genotyping with gold nanoparticle probes
Nanoparticle-based Up-converting Phosphor Technology
Surface-Enhanced Resonant Raman Spectroscopy
Near-infrared (NIR)-emissive polymersomes
Nanobiotechnology for detection of proteins
Captamers with proximity extension assay for proteins
Nanobiosensors
Cantilevers as biosensors for molecular diagnostics
Advantages of cantilever technology for molecular recognition
Antibody-coated nanocantilevers for detection of microorganisms
Cantilevers for direct detection of active genes
Portable nanocantilever system for diagnosis
Carbon nanotube biosensors
Carbon nanotube sensors coated with ssDNA and electronic readout
Carbon nanotubes sensors wrapped with DNA and optical detection
FRET-based DNA nanosensor
Ion Channel Switch biosensor technology
Electronic nanobiosensors
Electrochemical nanobiosensor
Metallic nanobiosensors
Quartz nanobalance biosensor
Viral nanosensor
PEBBLE nanosensors
Nanosensors for glucose monitoring
Microneedle-mounted biosensor
Optical biosensors
Laser nanosensors
Nanoshell biosensors
Plasmonics and SERS nanoprobes
Novel optical mRNA biosensor
Optonanogen biosensor
Surface plasmon resonance technology
Surface Enhanced Micro-optical Fluidic Systems
Nanoparticle-enhanced sensitivity of fluorescence-based biosensors
Nanowire biosensors
Nanowire biosensors for detection of single viruses
Nanowires for detection of genetic disorders
Nanowires biosensor for detecting biowarfare agents
Concluding remarks and future prospects of nanowire biosensors
Nanoscale erasable biodetectors
Future issues in the development of nanobiosensors
Applications of nanodiagnostics
Nanotechnology for detection of biomarkers
Nanotechnology for genotyping of single-nucleotide polymorphisms
Nanoparticles for detecting SNPs
Nanopores for detecting SNPs
Nanobiotechnologies for single molecule detection
Protease-activated quantum dot probes
Labeling of MSCs with QDs
Nanotechnology for detection of cancer
Dendrimers for sensing cancer cell apoptosis
Differentiation between normal and cancer cells by nanosensors
Gold nanoparticles for cancer diagnosis
Gold nanorods for detection of metastatic tumor cells
Implanted magnetic sensing for cancer
Nanoparticles designed for dual-mode imaging of cancer
Nanoatomic tubes for detection of cancer proteins
Nanodots for tracking apoptosis in cancer
Nanoparticles for the optical imaging of tumors
Nanolaser spectroscopy for detection of cancer in single cells
Nanotechnology-based single molecule assays for cancer
QDs for detection of tumors
QD-based test for DNA methylation
Nanotechnology for point-of-care diagnostics
Nanotechnology-based biochips for POC diagnosis
Nanoprobes for POC diagnosis
Carbon nanotube transistors for genetic screening
POC monitoring of vital signs with nanobiosensors
Detection of viruses
Cantilever beams for detection of single virus particles
Carbon nanotubes as biosensors for viruses
Electric fields for accelerating detection of viruses
QD fluorescent probes for detection of respiratory viral infections
Verigene SP Respiratory Virus Assay
Surface enhanced Raman scattering for detection of viruses
Detection of bacteria
QDs for detection of bacterial infections
SEnsing of Phage-Triggered Ion Cascade for detection of bacteria
Nanodiagnostics for the battle field and biodefense
An integrated nanobiosensor
Nanodiagnostics for integrating diagnostics with therapeutics
Companies involved in nanomolecular diagnostics
Concluding remarks about nanodiagnostics
Future prospects of nanodiagnostics
5. Nanobiotechnology in Drug Discovery & Development
Introduction
Nanobiotechnology for drug discovery
Nanofluidic devices for drug discovery
Gold nanoparticles for drug discovery
Tracking drug molecules in cells
SPR with colloidal gold particles
Use of quantum dots for drug discovery
Advantages of the use of QDs for drug discovery
Drawbacks of the use of QDs for drug discovery
Quantum dot for imaging drug receptors in the brain
Ligand-conjugated nanocrystals
Lipoparticles for drug discovery
Biosensor for drug discovery with Lipoparticles
Magnetic nanoparticles assays
Micelles for drug discovery
Nanolasers for drug discovery
Analysis of small molecule-protein interactions by nanowire biosensors
Cells targeting by nanoparticles with attached small molecules
Role of AFM for study of biomolecular interactions for drug discovery
Nanoscale devices for drug discovery
Nanotechnology enables drug design at cellular level
Nanobiotechnology-based drug development
Dendrimers as drugs
Fullerenes as drug candidates
Nanobodies
Role of nanobiotechnology in the future of drug discovery
Companies using nanobiotechnology for drug discovery
6. Nanobiotechnology in Drug Delivery
Introduction
Micronization versus nanonization for drug delivery
Nanoscale delivery of therapeutics
Nanobiotechnology solutions to the problems of drug delivery
Nanosuspension formulations
Nanotechnology for solubilization of water-insoluble drugs
Improved absorption of drugs in nanoparticulate form
Interaction of nanoparticles with human blood
Ideal properties of material for drug delivery
Nanomaterials and nanobiotechnologies used for drug delivery
Viruses as nanomaterials for drug delivery
Bacteria-mediated delivery of nanoparticles and drugs into cells
Nanoparticle-based drug delivery
Calcium phosphate nanoparticles
Cationic nanoparticles
Ceramic nanoparticles
Cyclodextrin nanoparticles for drug delivery
Dendrimers for drug delivery
DNA-assembled dendrimers for drug delivery
Fulleres for drug delivery
Amphiphilic fullerene derivatives
Fullerene conjugate for intracellular delivery of peptides
Gold nanoparticles as drug carriers
Layered double hydroxide nanoparticles
Nanocomposite membranes for magnetically triggered drug delivery
Nanocrystals
Nanocrystalline silver
Elan's NanoCrystal technology
Eurand's Biorise system
Nanodiamonds
Polymer nanoparticles
PLGA-based nanodelivery technologies
Polymeric micelles
Chitosan nanoparticles
QDs for drug delivery
Special procedures in nanoparticle-based drug delivery
Coated nanoparticles for penetrating cell membranes without damage
Drug delivery using “Particle Replication in Nonwetting Templates”
Encapsulating water-insoluble drugs in nanoparticles
Filomicelles vs spherical nanoparticles for drug delivery
Flash NanoPrecipitation
Magnetic nanoparticles for drug delivery
Nanoparticles bound together in spherical shapes
Perfluorocarbon nanoparticles for imaging and targeted drug-delivery
Prolonging circulation of nanoparticles by attachment to RBCs
Self-assembling nanoparticles for intracellular drug delivery
Trojan nanoparticles
Therapeutic protein delivery from nanoparticle-protein complexes
Liposomes
Basics of liposomes
Stabilization of phospholipid liposomes using nanoparticles
Lipid nanoparticles
Polymerized Liposomal Nanoparticle
Applications of lipid nanoparticles
Limitations of liposomes for drug delivery
Lipid nanocapsules
Lipid emulsions with nanoparticles
Nanostructured organogels
Liposomes incorporating fullerenes
Arsonoliposomes
Liposome-nanoparticle hybrids
Nanogels
Nanogel-liposome combination
Nanospheres
Nanosphere protein cages
Nanovesicle technology for delivery of peptides
Nanotubes
Carbon nanotubes for drug delivery
Lipid-protein nanotubes for drug delivery
Halloysite nanotubes for drug delivery
Nanocochleates
Nanobiotechnology and drug delivery devices
Coating of implants by ultrafine layers of polymers
Nano-encapsulation
Polymer nanocontainers
Nanotechnology-based device for insulin delivery
Mirocontainer delivery systems for cell therapy
Nanopore membrane in implantable titanium drug delivery device
Measuring the permeability of membranes
Nano-valves for drug delivery
Nanochips for drug delivery
Nanobiotechnology for vaccine delivery
Bacterial spores for delivery of vaccines
Nanoparticles for DNA vaccines
Proteosomes™ as vaccine delivery vehicles
“Smart” nanoparticles for delivery of vaccines
Nanospheres for controlled release of viral antigens
Nanobiotechnology for antisense drug delivery
Antisense nanoparticles
Dendrimers for antisense drug delivery
Polymer nanoparticles for antisense delivery system
Nanoparticle-mediated siRNA delivery
Chitosan-coated nanoparticles for siRNA delivery
Delivery of gold nanorod-siRNA nanoplex to dopaminergic neurons
Polymer-based nanoparticles for siRNA delivery
Polyethylenimine nanoparticles for siRNA delivery
siRNA-PEG nanoparticle-based delivery
Polycation-based nanoparticles for siRNA delivery
Calando's technology for targeted delivery of anticancer siRNA
Quantum dots to monitor RNAi delivery
Nanobiotechnology for gene therapy
Nanoparticle-mediated gene therapy
Calcium phosphate nanoparticles as nonviral vectors
Carbonate apatite nanoparticles for gene delivery
Gelatin nanoparticles for gene delivery
Immunolipoplex for delivery of p53 gene
Intravenous nanoparticle formulation for delivery of FUS1 gene
Lipid nanoparticles for targeted delivery of nucleic acids
Nanoparticles for imaging and intracellular delivery of nucleic acids
Nanoparticles as nonviral vectors for CNS gene therapy
Nanoparticles linked to viral vectors for photothermal therapy
Nanoparticles for p53 gene therapy of cancer
Nanoparticles with virus-like function as gene therapy vectors
Silica nanoparticles for gene delivery
Targeted nanoparticle-DNA delivery to the cardiovascular system
Dendrimers for gene transfer
DNA-PEG complexes as nanoparticles
Compacted DNA nanoparticles
Cochleate-mediated DNA delivery
Nanorod gene therapy
NanodelÔ gene vector
Nanomagnets for targeted cell-based cancer gene therapy
NanoNeedles for delivery of genetic material into cells
Nanomachines for gene delivery
Application of pulsed magnetic field and superparamagnetic nanoparticles
Nanocomposites for gene therapy
Nonionic polymeric micelles for oral gene delivery
Nanocarriers for simultaneous delivery of anticancer drugs and DNA
Delivery of siRNA by nanosize liposomes
Nanobiotechnology-based drug delivery in cancer
Nanoparticle formulations for drug delivery in cancer
Anticancer drug particles incorporated in liposomes
Encapsulating drugs in hydrogel nanoparticles
Exosomes
Folate-linked nanoparticles
Iron oxide nanoparticles
Lipid based nanocarriers
Micelles for drug delivery in cancer
Minicells for targeted delivery of nanoscale anticancer therapeutics
Nanomaterials for delivery of poorly soluble anticancer drugs
Nanoparticle formulations of paclitaxel
Nanoparticles containing albumin and antisense oligonucleotides
Non-aggregating nanoparticles
Pegylated nanoliposomal formulation
Poly-2-hydroxyethyl methacrylate nanoparticles
Protosphere nanoparticle technology
Multifunctional nanoparticles for treating brain tumors
Nanoparticles for targeted delivery of anticancer therapeutics
Antiangiogenic therapy using nanoparticles
Canine parvovirus as a nanocontainer for targeted drug delivery
Carbon magnetic nanoparticles for targeted drug delivery in cancer
Carbon nanotubes for targeted drug delivery to cancer cells
Cyclosert system for targeted delivery of anticancer therapeutics
Fullerenes for enhancing tumor targeting by antibodies
Gold nanoparticles for targeted drug delivery in cancer
Lipoprotein nanoparticles targeted to cancer-associated receptors
Magnetic nanoparticles for remote-controlled drug delivery to tumors
Nanobees for targeted delivery of cytolytic peptide melittin
Nanocell for targeted drug delivery to tumor
Nanoimmunoliposome-based system for targeted delivery of siRNA
Targeted delivery of nanoparticulate drugs into lymphatic system
Nanoparticles for targeted antisense therapy of cancer
Nanoparticles for delivery of suicide DNA to prostate tumors
Polymer nanoparticles for targeted drug delivery in cancer
Polymersomes for targeted cancer drug delivery
Quantum dots and quantum rods for targeted drug delivery in cancer
Targeted drug delivery with nanoparticle-aptamer bioconjugates
Dendrimers for anticancer drug delivery
Application of dendrimers in boron neutron capture therapy
Application of dendrimers in photodynamic therapy
Dendrimer-based synthetic vector for targeted cancer gene therapy
Devices for nanotechnology-based cancer therapy
Convection-enhanced delivery with nanoliposomal CPT-11
Nanocomposite devices
Nanoengineered silicon for brachytherapy
Nanoparticles combined with physical agents for tumor ablation
Boron neutron capture therapy using nanoparticles
Laser-induced cancer destruction using nanoparticles
Photodynamic therapy of cancer using nanoparticles
Thermal ablation using nanoparticles
Thermosensitive affibody-conjugated liposomes
Ultrasound radiation of tumors combined with nanoparticles
RNA nanotechnology for delivery of cancer therapeutics
Delivery of siRNAs for cancer
Nanocarriers for simultaneous delivery of multiple anticancer agents
Nanotechnology-based drug delivery to the CNS
Nanoencapsulation for delivery of vitamin E for CNS disorders
Nanoparticle technology for drug delivery across BBB
Delivery across BBB using NanoDelÔ technology
NanoMed technology to mask BBB-limiting characteristics of drugs
Nanovesicles for transport across BBB
Nanotechnology-based drug delivery to brain tumors
Nanoparticles for delivery of drugs to brain tumors across BBB
Nanoparticle delivery across the BBB for imaging and therapy of brain tumors
Intravenous gene delivery with nanoparticles into brain tumors
PLA nanoparticles for controlled delivery of BCNU to brain tumors
Nanotechnology-based devices and implants for CNS
Nanoparticle-based drug delivery to the inner ear
Nanobiotechnology in cardiovascular drug delivery
Liposomal nanodevices for targeted cardiovascular drug delivery
Drugs encapsulated in biodegradable nanoparticles
Nanotechnology-based drug-eluting stents
Drugs encapsulated in biodegradable nanoparticles
Magnetic nanoparticle-coated DES
Nanopores to enhance compatibility of drug-eluting stents
Low molecular weight heparin-loaded polymeric nanoparticles
Injectable peptide nanofibers for myocardial ischemia
Nanotechnology approach to the vulnerable plaque as cause of cardiac arrest
Nanobiotechnology-based transdermal drug delivery
Delivery of nanostructured drugs from transdermal patches
Ethosomes for transdermal drug delivery
NanoCyte transdermal drug delivery system
Nanoparticles for targeted therapeutic delivery to the liver
Nanoparticles for pulmonary drug delivery
Systemic drug delivery via pulmonary route
Nanoparticle drug delivery for effects on the respiratory system
Fate and toxicology of nanoparticles delivered to the lungs
Nanoparticle drug formulations for spray inhalation
Inhalation of glucose-sensitive nanoparticle for regulated release of insulin
Pulmonary drug delivery by surface acoustic wave technology
In vivo lung gene transfer using compacted DNA nanoparticles
Nasal drug delivery using nanoparticles
Mucosal drug delivery with nanoparticles
Companies involved in nanobiotechnology-based drug delivery
Future prospects of nanotechnology-based drug delivery
Nanomolecular valves for controlled drug release
Nanosponge for drug delivery
Nanomotors for drug delivery
7. Clinical Applications of Nanobiotechnology
Introduction
Nanomedicine
Clinical nanodiagnostics
Nano-endoscopy
Application of nanotechnology in radiology
High-resolution ultrasound imaging using nanoparticles
Nanobiotechnology combined with stem cell-based therapies
Nanobiotechnology in tissue engineering
3D nanofilament-based scaffolds
Electrospinning technology for bionanofabrication
Nanomaterials for tissue engineering of muscles
Carbon nanotubes for artificial muscles
Nanofibers for tissue engineering of skeletal muscle
Nanomaterials for combining tissue engineering and drug delivery
Nanobiotechnology for organ replacement and assisted function
Exosomes for drug-free organ transplants
Nanobiotechnology and organ-assisting devices
Nanotechnology-based human nephron filter for renal failure
Blood-compatible membranes for renal dialysis
Nanosurgery
Miniaturization in surgery
Nanotechnology for hemostasis during surgery
Minimally invasive surgery using catheters
Nanorobotics
Nanoscale laser surgery
Nanooncology
Nanobiotechnology for early detection of cancer to improve treatment
Impact of nanotechnology-based imaging in management of cancer
Nanoparticle-MRI for tracking dendritic cells in cancer therapy
Nanoparticle-CT scan
QDs aid lymph node mapping in cancer
Nanosensor device as an aid to cancer surgery
Role of nanoparticle-based imaging in oncology clinical trials
Nanoparticle-based anticancer drug delivery to overcome MDR
Nanoparticle-based management of cancer metastases
Nanoshells for thermal ablation in cancer
Nanobody-based cancer therapy
Nanoparticles for targeting tumors
Nanocarriers with TGF-b inhibitors for targeting cancer
Nanoshell-based cancer therapy
Nanobomb for cancer
Combination of diagnostics and therapeutics for cancer
Biomimetic nanoparticles targeted to tumors
Dendrimer nanoparticles for targeting and imaging tumors
Gold nanorods for diagnosis plus photothermal therapy of cancer
Magnetic nanoparticles for imaging as well as therapy of cancer
Nanobialys for combining MRI with delivery of anticancer agents
Nanoparticles, MRI and thermal ablation of tumors
pHLIP nanotechnology for detection and targeted therapy of cancer
QD conjugates combine cancer imaging, therapy and sensing
Radiolabeled carbon nanotubes for tumor imaging and targeting
Self-assembling nanoparticles for imaging and therapy of cancer
Targeted therapy with magnetic nanomaterials guided by antibodies
Ultrasonic tumor imaging and targeted chemotherapy by nanobubbles
A cancer killing device based on nanotechnology
Nanoparticles for protection against adverse effects of radiation therapy
Fullerenes for protection against chemotherapy-induced cardiotoxicity
Role of nanobiotechnology in personalized management of cancer
Concluding remarks on nanooncology
Nanoneurology
Nanobiotechnology for study of the nervous system
Nanowires for monitoring brain activity
Nanoparticles and MRI for macrophage tracking in the CNS
Nanoparticles for tracking stem cells for therapy of CNS disorders
Nanobiotechnology for neurotherapeutics
Nanowire neuroprosthetics with functional membrane proteins
Nanoparticles for neuroprotection
Nanotube-neuron electronic interface
Nanofibers as an aid to CNS regeneration by neural progenitor cells
Nanobiotechnology-based devices for restoration of neural function
Nanobiotechnology-based artificial retina
Nanoneurosurgery
Femtolaser neurosurgery
Nanofiber brain implants
Nanoparticles as an aid to neurosurgery
Nanoparticles for repair of spinal cord injury
Nanoscaffold for CNS repair
Electrospun nanofiber tubes for regeneration of peripheral nerves
PEBBLEs for brain tumor therapy
Bucky balls for brain cancer
Application of nanotechnology to pain therapeutics
Nanotechnology-based management of diabetes
Nanocardiology
Nanotechnology-based diagnosis and treatment
Use of perfluorocarbon nanoparticles in cardiovascular disorders
Cardiac monitoring in sleep apnea
Detection and treatment of atherosclerotic plaques in the arteries
Nanolipoblockers for atherosclerotic arterial plaques
IGF-1 delivery by nanofibers to improve cell therapy for myocardial infarction
Tissue engineering and regeneration of the cardiovascular system
Restenosis after percutaneous coronary angioplasty
Nanotechnology-based personalized medicine for cardiovascular disorders
Monitoring for disorders of blood coagulation
Nanoorthopedics
Application of nanotechnology for bone research
Reducing reaction to orthopedic implants
Enhancing the activity of bone cells on the surface of orthopedic implants
Nanobone implants
Synthetic nanomaterials as bone implants
Carbon nanotubes as scaffolds for bone growth
Aligning nanotubes to improve artificial joints
Cartilage disorders of knee joint
Role of nanotechnology in engineering of a replacement for cartilage
Nanotechnology as an aid to arthroscopy
Scanning force arthroscope
Nanodentistry
Bonding materials
Dental caries
Nanospheres for dental hypersensitivity
Nanomaterials for dental filling
Nanomaterials for dental implants
Nanoophthalmology
Nanocarriers for ocular drug delivery
Nanoparticle-based topical drug application to the eye
Chitosan nanoparticles for topical drug application to the eye
Polylactide nanoparticles for topical drug application to the eye
Ophthalmic drug delivery through nanoparticles in contact lenses
Nanoparticles for intraocular drug delivery
DNA nanoparticles for nonviral gene transfer to the eye
Nanotechnology for treatment for age-related macular degeneration
Nanotechnology-based therapeutics for eye disorders
Nano-engineered cornea
Use of dendrimers in ophthalmology
Nanotechnology for prevention of neovascularization
Regeneration of the optic nerve
DNA nanoparticles for gene therapy of retinal degenerative disorders
Nanobiotechnology for treatment of glaucoma
Nanomicrobiology
Nanobiotechnology and virology
Study of interaction of nanoparticles with viruses
Study of pathomechanism of viral diseases
Transdermal nanoparticles for immune enhancement in HIV
Nanofiltration to remove viruses from plasma transfusion products
Role of nanobacteria in human diseases
Nature of nanobacteria
Nanobacteria and kidney stone formation
Nanobacteria in cardiovascular disease
Nanotechnology-based microbicidal agents
Nanoscale bactericidal powders
Nanotubes for detection and destruction of bacteria
Carbon nanotubes as antimicrobial agents
Nanoemulsions as microbicidal agents
Silver nanoparticle coating as prophylaxis against infection
Nanotechnology-based antiviral agents
Nanocoating for antiviral effect
Fullerenes as antiviral agents
Nanoviricides
Nanotechnology-based vaccines
Nanofiltration of blood in viral diseases
Nanoparticles to combat biological warfare agents
Companies developing antiinfective agents
Nanoimmunology
Nanomedical aspects of oxidative stress
Nanoparticle antioxidants
Fullerene-based antioxidants
Ceria nanoparticles as neuroprotective antioxidants
Antioxidant nanoparticles for treating diseases due to oxidative stress
Nanotechnology for wound healing
Nanotechnology-based products for skin disorders
Nanoparticles for improving targeted topical therapy of skin
Topical nanocreams for inflammatory disorders of the skin
Nanoparticle-based sun screens
Cubosomes for treating skin disorders of premature infants
Nanobiotechnology for disorders of aging
Personal care products based on nanotechnology
Nanotechnology for hair care
Nanoparticles for chemo-radioprotection
Role of nanobiotechnology in biodefense
Nanosuspension formulations for treating bioweapon-mediated diseases
Use of antidotes as nanoparticulate formulations
Removal of toxins from blood
Blood substitutes
Artificial red cells
Companies using nanotechnology for healthcare
Nanobiotechnology for public health
Nanobiotechnology and nutrition
Nanobiotechnology and food industry
Role of nanobiotechnology in personalized nutrition
Nanobiotechnology research in the academic centers
Future potential of nanomedicine
US Federal funding for nanobiotechnology
Nanomedicine initiative of NIH
NIH Nanomedicine Center for Nucleoprotein Machines
NCI Alliance for Nanotechnology in Cancer
Research in cancer nanotechnology sponsored by the NCI
Global Enterprise for Micro-Mechanics and Molecular Medicine
8. Ethical, Safety and Regulatory issues
Introduction
Ethical and social implications of nanobiotechnology
Nanoethics
Nanotechnology patents
Quantum dot patents relevant to healthcare applications
Challenges and future prospects of nanobiotechnology patents
Legal aspects of nanobiotechnology
Nanotechnology standards
Preclinical testing of nanometerials for biological applications
Safety concerns about nanobiotechnology
Environmental safety of aerosols released from nanoparticle manufacture
Toxicity of nanoparticles
Testing for toxicity of nanoparticles
In vitro testing of nanoparticle toxicity
Variations in safety issues of different nanoparticles
Carbon nanotube safety
Fullerene toxicity
Gold nanoparticle toxicity
Quantum dot safety issues
Fate of nanoparticles in the human body
Pulmonary effects of nanoparticles
Blood compatibility of nanoparticles
Carbon nanoparticle-induced platelet aggregation
Compatibility of lipid-based nanoparticles with blood and blood cells
Transfer of nanoparticles from mother to fetus
Cytotoxicity of nanoparticles
Neuronanotoxicology
Nanoparticle deposits in the brain
Nanoparticles and neurodegeneration
Measures to reduce toxicity of nanoparticles
A screening strategy for the hazard identification of nanomaterials
Concluding remarks on safety issues of nanoparticles
Research into environmental effects of nanoparticles
Role of US government agencies in research on safety of nanoparticles
Work at NanoSafety Laboratories Inc UCLA
Center for Biological and Environmental Nanotechnology
European NEST project for risk assessment of exposure to nanoparticles
Efforts by nanotechnology companies to establish safety of nanoparticles
Public perceptions of the safety of nanotechnology
Evaluation of consumer exposure to nanoscale materials
Safety of nanoparticle-based cosmetics
Regulations in the European Union
Nanotechnology-based sunscreens
Cosmetic industry’s white paper on nanoparticles in personal care
Skin penetration of nanoparticles used in sunscreens
EPA safety requirements for silver nanoparticles
FDA regulation of nanobiotechnology products
FDA and nanotechnology-based medical devices
FDA’s Nanotechnology Task Force
FDA collaboration with agencies/organizations relevant to nanotechnology
Regulation of nanotechnology in the European Union
UK government policy on safety of nanoparticles
Safety recommendations of the Royal Society of UK
European Commission and safety of nanocosmetics
9. Nanobiotechnology Markets
Introduction
Markets according to areas of applications
Markets for nanomedicine
Markets for nanodiagnostics
Imaging agents
Pharmaceuticals
Role of nanobiotechnology in drug delivery market
Nanobiotechnology in life sciences research market
Markets according to technologies
Markets for nanomaterials
Markets for biomedical nanodevices
Markets for nanosensors
Markets for nanotools
Geographical distribution of markets
Nanobiotechnology in the US
Nanobiotechnology in the European Union
Nano2Life
European Technology Platform on NanoMedicine
Nanobiotechnology in Australia
Nanobiotechnology in Asia
Japan
South Korea
China
Taiwan
India
Nanobiotechnology in Russia
Nanobiotechnology in the developing world
Venture capital investment in nanotechnology
Big pharma and nanotechnology
Impact of nanobiotechnology on markets for current pharmaceuticals
Unmet needs in nanobiotechnology
Drivers for the development of nanobiotechnology markets
Strategies for developing markets for nanobiotechnology
Collaborations of industry with academic research centers
Collaborations of pharmaceutical and nanotechnology companies
Collaboration of chemical industry and the government
Cost-benefit of nanotechnology-based drug delivery
Education of healthcare professionals
Education of the public
10. References
Tables
Table 1-1: Dimensions of various objects in nanoscale
Table 1-2: Classification of basic nanobiotechnologies
Table 1-3: Historical landmarks in the evolution of nanotechnology
Table 2-1: Companies with nanoarray and nanofluidic technologies
Table 2-2: Applications of cantilever technology
Table 2-3: Applications of optical nanoscopy
Table 2-4: Companies that provide microscopes for nanobiotechnology
Table 2-5: Nanobiotechnological applications of S-layers
Table 2-6: Potential applications of dendrimers in nanobiotechnology
Table 2-7: Nanomaterials for biolabeling
Table 2-8: Companies providing services and products for nanobiotechnology industry
Table 3-1: Nanomaterials for the study of mitochondria
Table 3-2: Companies that provide nanotechnologies for life sciences research
Table 4-1: Nanotechnologies with potential applications in molecular diagnostics
Table 4-2: Nanobiotechnologies for single molecule detection
Table 4-3: Companies developing nanomolecular diagnostics
Table 5-1: Basic nanobiotechnologies relevant to drug discovery
Table 5-2: Companies involved in nanobiotechnology-based drug discovery and development
Table 6-1: Comparison of features of drug delivery by micronization vs nanonization
Table 6-2: Nanomaterials used for drug delivery
Table 6-3: Liposome-nanoparticle hybrid systems
Table 6-4: Examples of application of nanoparticles for gene therapy
Table 6-5: Classification of nanobiotechnology approaches to drug delivery in cancer
Table 6-6: Companies involved in nanobiotechnology-based drug delivery
Table 7-1: Nanomedicine in the 21st century
Table 7-2: Applications of nanobiotechnology for neurological disorders
Table 7-3: Nanoparticles used for drug delivery in ophthalmology
Table 7-4: Companies using nanotechnology-based antiinfective agents
Table 7-5: Companies using nanotechnology for healthcare and therapeutics
Table 7-6: Applications of nanotechnologies in food and nutrition sciences
Table 7-7: Non-commercial institutes/laboratories involved in nanobiotechnology
Table 8-1: FDA-approved nanotechnology based drugs
Table 9-1: Nanobiotechnology markets according to areas of application 2008-2018
Table 9-2: Markets for nanobiotechnology according to technologies 2008-2018
Table 9-3: Geographical distribution of nanobiotechnology markets 2008-2018
Table 9-4: Drivers for the development of nanobiotechnology markets
Table 9-5: Strategies for developing markets for nanobiotechnology
Table 9-6: Cost-benefit of nanotechnology-based drug delivery
Figures
Figure 1-1: Top-down and bottom-up approaches
Figure 1-2: Relationship of nanobiotechnology to healthcare and related technologies
Figure 2-1: Schematic representation of Dip Pen Nanolithography (DPN)
Figure 2-2: The core, branching and surface molecules of dendrimers
Figure 4-1: Scheme of bio-barcode assay
Figure 4-2: Scheme of a novel optical mRNA biosensor
Figure 4-3: Surface plasmon resonance (SPR) technology
Figure 4-4: Concept of nanopore-based sequencing
Figure 5-1: Application of nanobiotechnology at various stages of drug discovery
Figure 6-1: Bacteria plus nanoparticles for drug delivery into cells
Figure 6-2: A lipid nanoparticle
Figure 6-3: Lipid-protein nanotubes for drug delivery
Figure 6-4: Nanocochleate-mediated drug delivery
Figure 6-5: NanodelÔ gene vector
Figure 6-6: Use of micelles for drug delivery
Figure 7-1: Role of nanobiotechnology in personalized management of cancer
Figure 9-1: Components of the $1 trillion market for nanotechnologies in the year 2015
Figure 9-2: Nanobiotechnology markets according to applications 2008-2018
Figure 9-3: Geographical distribution of nanobiotechnology markets 2008-2018
Figure 9-4: Unmet needs in nanobiotechnology applications
10. Nanobiotech Companies
Introduction
Classification of companies
Profiles
Collaborations
Tables
Table 10-1: Collaborations in nanobiotechnology
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