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AIIRBS: Benefits Beyond Blood Pressure: Seeking Indications Throughout The Cardiovascular Continuum


Description: An almost constant stream of trial results for Aiirbs in additional indicationscan be expected over the period to 2006/7. If these trials are positive, salesof the Aiirbs will increase dramatically.Being better tolerated than older anti-hypertensives and potentially effectivethroughout the cardiovascular continuum, the Aiirbs look set to dominate theanti-hypertensives market.


Contents: EXECUTIVE SUMMARY Introduction The importance of additional indications The role of angtiotensin throughout the CVD continuum Potential benefits beyond blood pressure control The effect of AIIRBs on arterial distensibility and central pressure Effects on atherosclerosis Effects on pathologic changes in the heart and vascular wall Effects on diabetic retinopathy Effects on diabetic nephropathy Effects in heart failure Effects on the central nervous system Effects on dementia Effects on regulation of cerebral blood flow and brain ischemia Effects as secondary prevention Future potential of AIIRBs REFERENCES




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