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Advances in Coronary Angioplasty: Drug Eluting Stents
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Description: |
The development of drug-eluting stents has emerged since the use of stenting became particularly prevalent, especially in the US. Stents are currently used in approximately 70%-90% of cardiovascular interventional procedures and have been shown to reduce the need for repeat percutaneous transluminal coronary angioplasty (Ptca) due to restenosis. There are, however, issues of in-stent thrombosis and in-stent restenosis that need to be addressed when analyzing the results of clinical trial data. Over the next few years, additional long-term studies will aim to provide details of the long-term outcome for drug-eluting stents. In light of recent advances in this field of research, this brief sets out to: *describe the stenting procedure and outline the overall use of stents in coronary interventional procedures *outline recent advances in procedures, such as brachytherapy and sonotherapy, and establish the main advantages and disadvantages of each type of intervention *analyze clinical trial data and company strategies for key drug-eluting stent programs, including in-depth review of sirolimus-eluting, paclitaxel-eluting and actinomycin D-eluting stent trials *compare drug-eluting stent developments against established interventions in order to determine the potential success and patient population for drug-eluting stents *provide a forecasted market size for the drug-eluting stent market to 2005, along with an identification of the key factors influencing the market during this period * analyze the potential impact of drug-eluting stents on pharmaceutical companies, in terms of the affect on the use of anti-thrombotic and anti restenotic agents. |
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Contents: |
Datamonitor Healthcare
CONTACT DETAILS
TABLE OF CONTENTS
EXECUTIVE SUMMARY
Introduction
The history of angioplasty
Current use of stents in interventional therapy
Definition of stenting
In-stent restenosis
Increased intervention costs
Epidemiology overview
Percutaneous transluminal coronary angioplasty (PTCA)
Recent advances in stent therapy
Brachytherapy
Sonotherapy
Coated stents
Radioactive stents
Pipeline for drug-eluting stents
Sirolimus-eluting stent
RAVEL: zero restenosis
Cypher: Is it really too good to be true?
Will drug-eluting stents prove too costly?
Potential strategic alliances for Cordis
Market implications of drug-eluting stents
Paclitaxel-eluting stents
SCORE trial terminated
Increasing presence in the medical device market
Initial results from the paclitaxel-eluting stent trial
Strategic alliances to maximize potential revenue
Actinomycin D-eluting stent
Comparative analysis
Competition between drug-eluting stents
Market forecasts for drug-eluting stents
Potential impact on antithrombotic drug therapy?
Appendix
Bibliography
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Advances in Coronary Angioplasty: Drug Eluting Stents
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