Contents:

STUDY OVERVIEW - Research Objective and Methodology - Data Visualization and Interpretation - Benchmark Class - Participant Qualification - Data Views and Benchmark Class Segmentation BENCHMARK DATA - Scope of CMC Operations - Company Revenues (2007) - Percent of CMC Activities Outsourced CMC ACTIVITIES - Percent of Companies Performing API Chemical - Percent of Companies Performing API Biologics - Percent of Companies Performing DP Activities - Percent of Companies Performing Packaging - Percent of Companies Performing Analytics - Percent of Companies Performing Other Activities CMC FACILITIES - Number of Labs/Plants for CMC Development - Mean Geographic Breakdown of Facilities - Facility Type Breakdown by Geographic Area CMC RESOURCES & EDUCATION LEVELS - CMC FTEs - Percent of Total Global CMC FTEs - Percent of FTEs in Each Function - Percentage of FTEs with Advanced Degrees CMC OUTPUTS AND DEVELOPMENT TIMEFRAMES - Number of Drug Development Projects (2007) - Number of CMC Batches - Percent of CTM Work Completed by CMOs - Number of CMOs Used - CMC Development Timeframes (in months) - API Chemical Timeframes (in months) - API Biologic Timeframes (in months) - CTM Timeframes (in months) CMC CAPABILITIES CMC PERFORMANCE AND MEASURES CMC EFFICIENCY RATIOS CMC FTEs per $100 Million Revenue - Number of Projects per $100 Million Revenue - Number of FTEs per Project - Number of Batches per $100 Million Revenue - Batches per DP FTE - Batches per CMC FTE - Batches per DP, Packaging and Clinical FTE - Lab Error Ratio - Out-of-Standard Ratio - DP, Packaging, Clinical Supply FTE - Percent of Outsourced Work LESSONS LEARNED - Improving CMC Operations APPENDIX - Survey Instrument

Companies Mentioned

- Johnson & Johnson - Daiichi Sankyo - Pfizer - Gilead Sciences - GlaxoSmithKline - Novartis - Sanofi-Aventis - Merck - Abbott Laboratories - Boehringer Ingelheim - Baxter Healthcare - Takeda Pharmaceuticals - Astellas - Eisai - Alcon Laboratories - Solvay Pharmaceuticals - Biogen Idec - Bausch & Lomb