Contents:

Innovations in medical imaging Executive Summary Introduction Current issues in medical imaging & recent breakthroughs Challenges, opportunities & regulations Market, trends & future directions Chapter 1 Introduction What does medical imaging encompass? Anatomical & functional imaging Why is medical imaging of value to the pharmaceutical industry? Applications of medical imaging in drug R&D Leading imaging modalities X-Ray Computed tomography Magnetic resonance imaging Functional MRI Optical near-infrared fluorescence imaging Ultrasound Nuclear medicine Positron Emission Tomography Single Photon Emission Computed Tomography Other imaging modalities Video imaging Comparison of imaging modalities: in vivo & ex vivo applications Advantages & disadvantages of imaging modalities Therapeutic applications Cancer Breast cancer Colorectal cancer Cardiovascular disease Coronary artery disease Stroke Other cardiovascular conditions Gastrointestinal conditions Orthopedics & osteoporosis CNS and thoracic trauma Therapeutic conclusions Chapter 2 Current issues in medical imaging & recent breakthroughs Pre-processing & post-processing issues Artifacts Noise Noise & artifact reduction Raw data acquisition & image reconstruction Image enhancement & portioning Conclusions on imaging issues Breakthroughs in medical imaging Novel imaging agents CT imaging agents MRI imaging agents Ultrasound imaging agents PET & SPECT imaging agents Imaging agent conclusions Novel scintillator & detectors Multimodality imaging devices SPECT-CT & PET-CT hybrids Spectral CT High field MRI Conclusions on imaging breakthroughs Chapter 3 Challenges, opportunities & regulations Geographical challenges & opportunities US market growth & legislative impact International markets and changing dynamics Urbanization and rise of the emerging markets Patient demographics: therapeutic dynamics Technical Challenges & Opportunities Molecular imaging Molecular imaging probes Regulatory support Molecular imaging consortia Imaging task forces Targeted and multifunctional imaging agents Nanotechnology Nano-enabled delivery Nano imaging materials Targeted contrast agents Multifunctional imaging agents Novel imaging modalities Magnetic Particle Imaging PET-MRI Real-time whole animal imaging Multi-spectral opto-acoustic tomography Computer assisted imaging & virtual surgery Virtual surgery Breakthrough conclusions Reimbursement & regulations Overall conclusions Chapter 4 Market trends & future directions The medical imaging market Leading manufacturers of medical imaging equipment Leading healthcare companies GE Healthcare, New York, US Hitachi Medical Corporation, Tokyo, Japan Philips Medical Systems, Amsterdam, The Netherlands Siemens Medical Solutions, Berlin & Munich, Germany Toshiba Medical Systems Corporation, Tokyo, Japan M&A activity Recent market trends Global trends in medical imaging Technological trends in imaging equipment Imaging agents & nanotechnology Image-guided radiation therapy and patient selection Future directions Molecular imaging & diagnostics Medical imaging informatics and networking Medical imaging and virtual reality Summary & overall conclusions Chapter 5 Appendices Primary research methodology Companies involved in medical imaging Glossary Acknowledgements Index Bibliography & Endnotes List of Figures Figure 1.1: Medical imaging uses a spectrum of wavelengths Figure 1.2: Medical imaging technologies Figure 1.3: Imaging techniques and their uses Figure 1.4: Medical imaging in the drug discovery & development process Figure 1.5: X-ray of a skull a) anterior-posterior and b) lateral view Figure 1.6: Computed tomography of the head a) coronal section and b) sagittal section Figure 1.7: X-ray imagers Figure 1.8: Evolution of CT imaging Figure 1.9: Magnetic resonance imaging of the head Figure 1.10: Functional magnetic resonance imaging of the brain Figure 1.11: Multispectral imaging of the arm (700-900 nm range) Figure 1.12: Ultrasound image of a baby in-utero Figure 1.13: Principles of PET imaging Figure 1.14: Fused PET/CT image of anatomy and function Figure 1.15: SPECT detection Figure 1.16: video imaging Figure 1.17: Therapeutic application of medical imaging Figure 1.18: Therapeutic applications of medical imaging Figure 2.19: Medical imaging workflow Figure 2.20: CT imaging artifacts Figure 2.21: US imaging artifacts Figure 2.22: US imaging artifacts Figure 2.23: Recent technological breakthroughs in medical imaging Figure 2.24: New scintillator materials Figure 2.25: Opportunities in PET & SPECT for better energy resolution Figure 2.26: Advances collimators focus and maximize SPECT-CT Figure 2.27: Schematic of Spectral CT technology Figure 2.28: Diffusion MRI - CNS Figure 3.29: Historical and future outlook of MR/CT revenues in the US (1997-2011) Figure 3.30: Global Population (2008) Figure 3.31: Population over 60: world and developed regions (1950-2050) Figure 3.32: Projected global deaths for selected conditions (2005-2030) Figure 3.33: Application of molecular imaging Figure 3.34: Delivery platforms for contrast agent Figure 3.35: Multifunctional agents Figure 3.36: Schematic of MPI technology Figure 3.37: IVIS Kinetic images in small animal models Figure 3.38: Real-time whole body optical imaging of Zebrafish List of Tables Table 1.1: Examples of image-related biomarkers with application in a variety of disease areas Table 1.2: Common PET positron-emitting tracer isotopes Table 1.3: Common SPECT radionuclides Table 1.4: Ex vivo imaging modalities Table 1.5: In vivo imaging modalities Table 1.6: Advantages & disadvantages of imaging modalities Table 3.7: Impact of American Recovery & Reinvestment Act (ARRA) on healthcare & medical imaging Table 3.8: Recent impact of investment & regulation on international healthcare & medical imaging markets Table 3.9: Typical effective radiation doses for medical imaging procedures Table 3.10: Leading manufacturers of small animal imaging equipment and probes Table 4.11: The medical imaging market – market leaders Table 4.12: Leading manufacturers of medical imaging equipment Table 4.3: Leading manufacturers of medical imaging equipment (cont) Table 4.4: Recent M&A activity in the medical imaging field Table 4.5: Recent M&A activity in the medical imaging field (continued) Table 5.16: The medical imaging market – leading companies in the US

Companies Mentioned

- 2D Imaging - Inc. AccuImage Diagnostics Corp. - AFP Medical Division - Agfa Medical - ALI Technologies - Ameritech Medical - LLC - Analogic Corp. - Avreo - Barco Medical Imaging - Biosound Inc. - BRIT Systems - Camtronics Medical Systems - CardioNow - CardioVascular Sales - Caliper Life Sciences - Cedara. - Clarte Imaging - Compumed - Computerized Thermal Imaging - ComView Corporation - Cyberpulse - DeJarnette Research Systems - Delft Diagnostic Imaging - DesAcc Inc. - Eigen - Emageon - EMED - Esaote Group - Evolved - Fischer Imaging - Fonar Corporation - Fuji Medical Systems - GE Healthcare - Gordon Instruments - Heartlab - Hermes Medical (Nuclear Diagnostics AB Hitachi Medical Systems America - Hologic Inc. - Howtek - Image Enhancement System - ImageLabs - Images-On-Call - Imaging Diagnostic Systems Inc. - Imaginis - IMCO Technologies - IMV Limited Medical Division - Infimed Inc. - Innovative Medical Solutions - Inphact - Instrumentarium - Kodak Health - KPI Ultrasound - Longport Inc. - Lumedx - Lunar Corporation - McKesson - Medcon Ltd. - Medic Imaging - Medis Medical Imaging Systems - Medison - Mennen Medical Systems - Merge Technologies - Merlin Engineering - Norland Medical Systems - North American Imaging - Novoste Corp. - Nycomed - Optimed Technologies - Osteometer Meditech - Pegasus Imaging Systems - Philips Medical Systems - Pie Medical - Planar Systems - ProSolv - RIS - Rogan Medical Systems - Schick Technologies - ScImage - Sectra - Shimadzu Medical Systems - Siemens Healthcare - Sony Medical Systems - StorCOMM Inc. - SwissRay - TeraRecon - TomTec Imaging Systems - Toshiba America Medical Systems - Varian Corporation - Vepro - Vidar - Vital Images Inc. - Voxar - Voxel - Witt Biomedical - X-Ray Marketing Associates