Contents:

1. METHODOLOGY 1 Study Reliability and Reporting Limitations 1 Disclaimers 2 Quantitative Techniques & Reporting Level 3 2. GLOBAL MARKET OVERVIEW 4 Drug Eluting Stents Steal the Show 4 Cypher and Taxus Dominate Global DES Market 4 A 10-Year Outlook for the Coronary Stents Industry 5 3. MARKET TRENDS AND ISSUES 6 Drug Eluting Stent System - Safety Concerns 6 Drug Eluting Stent Market to Bounce Back 6 Coronary Stents Market Challenged by Drug Therapy 7 Restenosis - the Real Growth Driver 7 Small Vessels - A Major Cause of Restenosis 7 Aging Population Propels Coronary Stent Market 8 Cell Transplantation - A Major Threat to Coronary Stents 8 Next Generation Stents - A Boon for Treating Coronary Diseases 8 Direct Stenting Systems Spur Growth 9 Drug Choice Impacts Market Entry 9 Price and Quality Concerns Dog Supplies and Demand for DES 9 DES’ Introduction Skyrockets Coronary Stent Prices 10 Legal Challenges Right Behind 10 New Competition Puts Tabs on Coronary Stenting 10 4. COMPETITIVE ANALYSIS 10 5. PRODUCT FACTS 12 Bare Metal Stents 12 Major Bare Metal Stents by Company 12 Drug Eluting Stents 12 Major Drug-Eluting Stents by Company 13 A Peek into Regulatory Approvals for Coronary Stents 13 6. RESEARCH AND DEVELOPMENT 14 Extensive R&D Underway in Global Drug- Eluting Stents Market 14 At the Labs 14 Other Products Under Trials - A Recent Past Perspective 15 OMT Developing R-stent 15 Reva Developing Stainless Steel Bare- Metal Stent 15 D & P Corp Developing Bovine Pericardium - Covered Stent 15 Advanced Bio Synthesizing Porous Drug - Eluting Stents 15 Lombard Medical Developing PEP Coatings 16 Shiga Develops Biodegradable Drug- Eluting Stent 16 7. CORPORATE DEVELOPMENTS 16 Medtronic Receives the US FDA Approval to Use Endeavor® Stent 16 Medtronic Inc. Receives Approval for its Drug- Eluting Stent, “Endeavor” In Canada 16 Boston Scientific to Market TAXUS® Liberte® Stent System in Canada 17 Abbott Applies for Approval of XIENCE™ V in Japan 17 Medinol Achieves CE Mark Approval for Presillion™ Cobalt Chromium Coronary Stent System 17 Iberhospitex Receives Spanish Approval to Sell Palau Pharma’s “Active” Coronary Stent 18 Clearstream’s Intrepide Drug Eluting Stent of Clearstream Receives CE mark approval 18 Terumo Introduces Its Drug-Eluting Stent in Germany and Marks Its European Entry 18 Tryton Medical’s Side-Branch Stent Achieves CE Mark Approval 18 CV Therapeutics Offers its Stent Coating Technology to Medlogics Device Corporation 18 Abbott’s 2.25mm-Sized XIENCE™ V Drug Eluting Stent receives CE Mark of Approval 19 Biosensors Receives CE Mark Approval For BioMatrix® Stent System 19 Nfocus Neuromedical’s CardioVasc™ Stent-Graft and Delivery System Receives CE Mark Approval 19 InspireMD - MGuard™ Coronary Stent Launched in Italy 20 CeloNova BioSciences Launches CATANIA™ Coronary Stent with Nano Thin Polyzene®-F 20 Angiotech Launches Cook Medical’s Drug Eluting Zilver® PTX™ Stent in New Zealand 20 Cook Medical’s Zilver Stent Receives Approval for Vascular Use In Canada 21 Boston Scientific to Market TAXUS® EXPRESS2 Stent System in Japan 21 CE Mark Granted for the Use of Drug-eluting Stent, TAXUS® Liberte™ in Diabetic Patients 21 Boston Scientific’s TAXUS® Liberte™ Long Stent Receives CE Mark Approval 21 Boston Scientific Launches Its Own Version of XIENCE™V Drug- Eluting Coronary Stent in Europe 22 8. CLINICAL TRIALS AND KEY STUDIES 22 Canadian Study Indicates Superior Clinical Benefits of Drug- Coated Stent 22 SPIRIT III Trial Confirms Superiority of Everolimus Eluting Coronary Stent, XIENCE™ V Over TAXUS® Stent 22 Network Meta-Analysis Demonstrates Low Mortality Rates for Both Drug-Eluting And Bare-Metal Stents 23 Study Proves Superiority of Cypher® Sirolimus-Eluting Coronary Stent in Reduction of Blood Clot Risks and Reintervention Compared to Taxus Stent 23 9. MAJOR PLAYERS 24 Angiotech Pharmaceuticals (Canada) 24 Boston Scientific Corp. (USA) 24 Cordis Corporation (JNJ) - (USA) 24 Cook Group, Inc. (USA) 25 Medtronic, Inc. (USA) 25 Medtronic Cardiovascular, Inc. (USA) 25 MIVI Technologies Inc. (Canada) 25 OrbusNeich (USA) 25 Sorin Biomedica Cardio (Italy) 26 Sun Biomedical Ltd. (USA) 26 10. MARKET ANALYTICS 27 11. THE UNITED STATES 33 Coronary Artery Disease - A US Perspective 33 Rapid Adoption of DES Technology in the US Market 33 Baby Boomers Boost Coronary Stent Market 33 Key Drivers of the US DES Market 34 Improved Treatment and Diagnosis 34 Long-Term Cost Reduction 34 Well-Organized Reimbursement System 34 Growing Patient Awareness 34 DES Technology - Economic Implications on the US Health Care System 35 Soaring Costs of Multivessel Treatment - Still a Major Problem 35 Competitive Scenario 35 Leading Players 35 Coronary Stents - Boston Scientific and JNJ Battle for Dominance 35 Regulatory Environment 37 12. JAPAN 39 Prospects Weighed down by Regulatory Entanglements 39 Japanese Government Steps in to Alleviate Pricing 39 Japanese Coronary Stents Command Higher Prices 39 Competitive Landscape 40 13. EUROPE 43 a. France 49 b. Germany 51 c. Italy 53 d. The United Kingdom 54 e. Spain 56 f. Russia 58 g. Rest of Europe 59 14. ASIA-PACIFIC 61 Coronary Stent Market in a Bubble Zone Now 61 Regional Players and their DES Development Efforts 61 Cost Focus Helps Stent Makers Win the Market Stunt 62 15. REST OF WORLD 63 Market Leaders 64 South Africa - Leading Players 64 EXHIBITS Table 1: Growth in Angioplasty Procedures Vs Stent Penetration Worldwide: (2006) Table 2: Percentage Breakdown of Leading Coronary Stents Manufacturer Revenues in the World - 2008 Table 3: Percentage Breakdown of Leading Bare Metal Stents Manufacturer Revenues in the World - 2008 Table 4: Percentage Breakdown of Leading Drug-Eluting Stent Manufacturer Revenues in the World - 2008 Table 5: Global Coronary Stents Market by Region for the Period 2007-2015 (Sales in US$ Million) Table 6: Percentage Breakdown (Dollar Sales) of Global Coronary Stents Market by Region for the Years 2008 & 2012 Table 7: Global Coronary Stents Market by Region for the Period 2007-2015 (Sales in Thousand Units) Table 8: Percentage Breakdown (Unit Sales) of Global Coronary Stents Market by Region for the Years 2008 & 2012 Table 9: Global Bare Metal Stents Market by Region for the Period 2007-2015 (Sales in US$ Million) Table 10: Percentage Breakdown (Dollar Sales) of Global Bare Metal Stents Market by Region for the Years 2008 & 2012 Table 11: Global Bare Metal Stents Market by Region for the Period 2007-2015 (Sales in Thousand Units) Table 12: Percentage Breakdown (Unit Sales) of Global Bare Metal Stents Market by Region for the Years 2008 & 2012 Table 13: Global Drug Eluting Stents Market by Region for the Period 2007-2015 (Sales in US$ Million) Table 14: Percentage Breakdown (Dollar Sales) of Global Drug Eluting Stents Market by Region for the Years 2008 & 2012 Table 15: Global Drug Eluting Stents Market by Region for the Period 2007-2015 (Sales in Thousand Units) Table 16: Percentage Breakdown (Unit Sales) of Global Drug Eluting Stents Market by Region for the Years 2008 & 2012 Table 17: Percentage Breakdown of Leading Coronary Stents Manufacturer Revenues in the US - 2006 Table 18: Percentage Breakdown of Leading Bare Metal Stents Manufacturer Revenues in the US - 2006 Table 19: Percentage Breakdown of Leading Drug-Eluting Stents Manufacturer Revenues in the US - 2008 Table 20: Coronary Stents Market by Segment in the US: 2007-2015 (Sales in US$ Million) Table 21: Percentage Breakdown (Dollar Sales) of Coronary Stents Market by Segment in the US for the Years 2008 & 2012 Table 22: Coronary Stents Market by Segment in the US: 2007-2015 (Sales in Thousand Units) Table 23: Percentage Breakdown (Unit Sales) of Coronary Stents Market by Segment in the US for the Years 2008 & 2012 Table 24: Comparative Analysis of Coronary Stent Prices - 2008 Table 25: Percentage Breakdown of Leading Coronary Stent Manufacturer Value Sales in Japan - 2006 Table 26: Percentage Breakdown of Leading Bare Metal Stent Manufacturer Value Sales in Japan - 2006 Table 27: Percentage Breakdown of Leading Drug-Eluting Stent Manufacturer Value Sales in Japan - 2008 Table 28: Coronary Stents Market by Segment in Japan: 2007-2015 (Sales in US$ Million) Table 29: Percentage Breakdown (Dollar Sales) of Coronary Stents Market by Segment in Japan for the Years 2008 & 2012 Table 30: Coronary Stents Market by Segment in Japan: 2007-2015 (Sales in Thousand Units) Table 31: Percentage Breakdown (Unit Sales) of Coronary Stents Market by Segment in Japan for the Years 2008 & 2012 Table 32: Percentage Breakdown of Leading Bare Metal Stent Manufacturer Value Sales in Europe - 2006 Table 33: Percentage Breakdown of Leading Drug-Eluting Stent Manufacturer Value Sales in Europe - 2006 Table 34: Coronary Stents Market by Region in Europe: 2007-2015 (Sales in US$ Million) Table 35: Percentage Breakdown (Dollar Sales) of Coronary Stents Market by Region in Europe for the Years 2008 & 2012 Table 36: Coronary Stents Market by Region in Europe: 2007-2015 (Sales in Thousand Units) Table 37: Percentage Breakdown (Unit Sales) of Coronary Stents Market by Region in Europe for the Years 2008 & 2012 Table 38: Coronary Stents Market by Segment in Europe: 2007-2015 (Sales in US$ Million) Table 39: Percentage Breakdown (Dollar Sales) of Coronary Stents Market by Segment in Europe for the Years 2008 & 2012 Table 40: Coronary Stents Market by Segment in Europe: 2007-2015 (Sales in Thousand Units) Table 41: Percentage Breakdown (Unit Sales) of Coronary Stents Market by Segment in Europe for the Years 2008 & 2012 Table 42: Coronary Stents Market by Segment in France: 2007-2015 (Sales in US$ Million) Table 43: Percentage Breakdown (Dollar Sales) of Coronary Stents Market by Segment in France for the Years 2008 & 2012 Table 44: Coronary Stents Market by Segment in France: 2007-2015 (Sales in Thousand Units) Table 45: Percentage Breakdown (Unit Sales) of Coronary Stents Market by Segment in France for the Years 2008 & 2012 Table 46: Coronary Stents Market by Segment in Germany: 2007-2015 (Sales in US$ Million) Table 47: Percentage Breakdown (Dollar Sales) of Coronary Stents Market by Segment in Germany for the Years 2008 & 2012 Table 48: Coronary Stents Market by Segment in Germany: 2007-2015 (Sales in Thousand Units) Table 49: Percentage Breakdown (Unit Sales) of Coronary Stents Market by Segment in Germany for the Years 2008 & 2012 Table 50: Coronary Stents Market by Segment in Italy: 2007-2015 (Sales in US$ Million) Table 51: Percentage Breakdown (Dollar Sales) of Coronary Stents Market by Segment in Italy for the Years 2008 & 2012 Table 52: Coronary Stents Market by Segment in Italy: 2007-2015 (Sales in Thousand Units) Table 53: Percentage Breakdown (Unit Sales) of Coronary Stents Market by Segment in Italy for the Years 2008 & 2012 Table 54: Coronary Stents Market by Segment in the UK: 2007-2015 (Sales in US$ Million) Table 55: Percentage Breakdown (Dollar Sales) of Coronary Stents Market by Segment in the UK for the Years 2008 & 2012 Table 56: Coronary Stents Market by Segment in the UK: 2007-2015 (Sales in Thousand Units) Table 57: Percentage Breakdown (Unit Sales) of Coronary Stents Market by Segment in the UK for the Years 2008 & 2012 Table 58: Coronary Stents Market by Segment in Spain: 2007-2015 (Sales in US$ Million) Table 59: Percentage Breakdown (Dollar Sales) of Coronary Stents Market by Segment in Spain for the Years 2008 & 2012 Table 60: Coronary Stents Market by Segment in Spain: 2007-2015 (Sales in Thousand Units) Table 61: Percentage Breakdown (Unit Sales) of Coronary Stents Market by Segment in Spain for the Years 2008 & 2012 Table 62: Coronary Stents Market by Segment in Russia: 2007-2015 (Sales in US$ Million) Table 63: Percentage Breakdown (Dollar Sales) of Coronary Stents Market by Segment in Russia for the Years 2008 & 2012 Table 64: Coronary Stents Market by Segment in Russia: 2007-2015 (Sales in Thousand Units) Table 65: Percentage Breakdown (Unit Sales) of Coronary Stents Market by Segment in Russia for the Years 2008 & 2012 Table 66: Coronary Stents Market by Segment in the Rest of Europe: 2007-2015 (Sales in US$ Million) Table 67: Percentage Breakdown (Dollar Sales) of Coronary Stents Market by Segment in the Rest of Europe for the Years 2008 & 2012 Table 68: Coronary Stents Market by Segment in the Rest of Europe: 2007- 2015 (Sales in Thousand Units) Table 69: Percentage Breakdown (Unit Sales) of Coronary Stents Market by Segment in the Rest of Europe for the Years 2008 & 2012 Table 70: Coronary Stents Market by Segment in Asia-Pacific: 2007-2015 (Sales in US$ Million) Table 71: Percentage Breakdown (Dollar Sales) of Coronary Stents Market by Segment in Asia-Pacific for the Years 2008 & 2012 Table 72: Coronary Stents Market by Segment in Asia-Pacific: 2007-2015 (Sales in Thousand Units) Table 73: Percentage Breakdown (Unit Sales) of Coronary Stents Market by Segment in Asia-Pacific for the Years 2008 & 2012 Table 74: Percentage Breakdown of Leading Coronary Stent Manufacturer Value Sales in Rest of World - 2006 Table 75: Percentage Breakdown of Leading Coronary Stent Manufacturer Unit Sales in Rest of World - 2006 Table 76: Coronary Stents Market by Segment in Rest of World: 2007-2015 (Sales in US$ Million) Table 77: Percentage Breakdown (Dollar Sales) of Coronary Stents Market by Segment in Rest of World for the Years 2008 & 2012 Table 78: Coronary Stents Market by Segment in Rest of World: 2007-2015 (Sales in Thousand Units) Table 79: Percentage Breakdown (Unit Sales) of Coronary Stents Market by Segment in Rest of World for the Years 2008 & 2012 COMPANIES PROFILED

Companies Mentioned

- Angiotech Pharmaceuticals (Canada) - Boston Scientific Corp. (USA) - Cordis Corporation (JNJ) - (USA) - Cook Group, Inc. (USA) - Medtronic, Inc. (USA) - Medtronic Cardiovascular, Inc. (USA) - MIVI Technologies Inc. (Canada) - OrbusNeich (USA) - Sorin Biomedica Cardio (Italy) - Sun Biomedical Ltd. (USA)