Contents:

EXECUTIVE SUMMARY INTRODUCTION OVERVIEW OF DRUG CLASSES Angiotensin converting enzyme (ACE) inhibitors Class overview Approved indications Angiotensin II receptor blockers (AIIRBs) Class overview Approved indications ACE inhibitors versus AIIRBs Global sales of the leading ACE inhibitors and AIIRBs Hypertensive patients receiving ACE inhibitors and AIIRBs Increased use of ACE inhibitors ACE INHIBITOR INTOLERANCE ACE inhibitor intolerance in the seven major markets Hypertensive patients Heart failure patients SPICE – Studies of Patients Intolerant to Converting Enzyme What causes intolerance to ACE inhibitors? Alternative therapy for ACE inhibitor intolerant patients Hypertensive patients Heart failure patients Review of clinical trial data ONTARGET and TRANSCEND – head-to-head trial CASE STUDY ACE inhibitor and AIIRB trends in England Prescription volume Prescription value Cost per prescription Branded enalapril versus generic enalapril Summary APPENDIX Datamonitor's Cardiovascular Business Unit Bibliography Further reading from Datamonitor