Printer Friendly Printed from http://www.researchandmarkets.com/reports/1108 ACE Inhibitor Intolerance: A major driver of growth for the Aiirbs Description: This brief explores in detail the impact of generic ACE inhibitors on the Aiirb market, a theme raised in recent Datamonitor reports covering antihypertensive drugs. It is particularly topical, given the recent FDA approval of Sankyo Pharma/Forest Laboratories'' new angiotensin II receptor blocker, Benicar (olmesartan) for marketing in the US. The Brief draws together and builds on Treatment Algorithm survey findings in heart failure and hypertension for 7 countries, with epidemiology data, literature search material and a case study based on UK Department of Health prescription audit data for England. The Brief provides: * detailed analysis of the estimated proportion of hypertensive and heart failure patients that are ACE intolerant in the seven major pharmaceutical markets (US, Japan, Germany, France, Italy, Spain, UK) * clinical trial data investigating ACE inhibitor intolerance * a breakdown of the causes of ACE inhibitor intolerance * assessment of alternative therapies for ACE intolerant patients * summary of ACE inhibitor and Aiirb prescription trends in England from 1998 to 2001, and an analysis of the impact of generic enalapril within this market Contents: EXECUTIVE SUMMARY INTRODUCTION OVERVIEW OF DRUG CLASSES Angiotensin converting enzyme (ACE) inhibitors Class overview Approved indications Angiotensin II receptor blockers (AIIRBs) Class overview Approved indications ACE inhibitors versus AIIRBs Global sales of the leading ACE inhibitors and AIIRBs Hypertensive patients receiving ACE inhibitors and AIIRBs Increased use of ACE inhibitors ACE INHIBITOR INTOLERANCE ACE inhibitor intolerance in the seven major markets Hypertensive patients Heart failure patients SPICE – Studies of Patients Intolerant to Converting Enzyme What causes intolerance to ACE inhibitors? Alternative therapy for ACE inhibitor intolerant patients Hypertensive patients Heart failure patients Review of clinical trial data ONTARGET and TRANSCEND – head-to-head trial CASE STUDY ACE inhibitor and AIIRB trends in England Prescription volume Prescription value Cost per prescription Branded enalapril versus generic enalapril Summary APPENDIX Datamonitor's Cardiovascular Business Unit Bibliography Further reading from Datamonitor Ordering: Order Online - visit http://www.researchandmarkets.com/reports/1108 Order by Fax - using the order form below Order By Post - print the order form below and send to Research and Markets, Guinness Centre, Taylors Lane, Dublin 8, Ireland. Page 1 of 2 Printed 30/08/2008 06:34:07 Fax Order Form To place an order via fax simply print this form, fill in the information below and fax the completed form to the number at the bottom of this page. If you have any questions please email help@researchandmarkets.com Order information Please verify that the product information is correct and select the format you require. Product Name: ACE Inhibitor Intolerance: A major driver of growth for the Aiirbs Web Address: http://www.researchandmarkets.com/reports/1108 Office Code: OCHGMJIOPPZ Report formats Please enter the quantity of the report format you require. Format Quantity Price Hard Copy €1,669.00 + EUR€ 50.00 Shipping/Handling * Electronic €2,033.00 Electronic - Site License €1,605.00 * Shipping/Handling is only charged once per order. Contact information Please enter all the information below in BLOCK CAPITALS. First Name:   Last Name:   Email Address: Job Title: Organisation: Address: City: Postal/Zip Code: Country: Phone Number: Fax Number: Please fax this form to: (646)607-1907 or (646)964-6609 - From USA +353-1-481-1716 or +353-1-653-1571 - From Rest of World Page 2 of 2 Printed 30/08/2008 06:34:07 Payment information Please indicate the payment method you would like to use by selecting the appropriate box.  Pay by Credit Card: American Express Diners Club Master Card Visa Cardholder Name: Expiry Date: / Card Number: CVV Security Code: Issue Date: /   (Diners Club only)  Pay by Check: Please post the check, accompanied by this form, to: Research and Markets, Guinness Centre, Taylors Lane, Dublin 8, Ireland.  Pay by Wire Transfer: Please transfer funds to: Account number: 83313083 Sort code: 98-53-30 Swift code: ULSBIE2D IBAN number: IE78ULSB98533083313083 Bank Address: Ulster Bank, 27-35 Main St, Blackrock, Co. Dublin, Ireland. If you have a Marketing Code please enter it below: Marketing Code: Please note that by ordering from Research and Markets you are agreeing to our Terms and Conditions at http://www.researchandmarkets.com/info/terms.asp Please fax this form to: (646)607-1907 or (646)964-6609 - From USA +353-1-481-1716 or +353-1-653-1571 - From Rest of World