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General and Applied Toxicology, 6 Volume Set, 3rd Edition
John Wiley and Sons Ltd, Oct 2009, Pages: 3,490
Encompassing 150 articles written by leading scientists in the field, the third edition of General and Applied Toxicology provides a comprehensive and in-depth review of the basic science of toxicology, its specializations, and the application of toxicological knowledge.
This new edition reflects developments within the field that have taken place since the second edition was published in 1999. These include:
- New information developed in the areas of both the fundamental and applied aspects of toxicology
- Considerable increase in the development of fundamental information and its applications, refinement of technical methods, advances in mechanistic toxicology, and greater interest in areas of toxicology previously regarded as of limited scope
- Changing approaches to methodological, interpretative, regulatory, and ethical aspects of basic and applied toxicology
General and Applied Toxicology, 3rd Edition is the first port of call for academic researchers, industrial researchers, regulatory professionals, and advanced students looking for timely and authoritative information in the field. Due to the increase in public and media interest in exposure to toxic substances, this provides an indispensable general reference source for general physicians, lawyers, law enforcement agencies, information resource facilities, and members of the general public.
This reference work is the third edition of General and Applied Toxicology (GAT). The first edition was published in 1993 (Groves Dictionaries), the second in 1999 (Palgrave Macmillan). The third edition of General and Applied Toxicology will be comprised of 120 articles written by experts in different aspects of toxicology for those working in toxicology in a broad range of fields, such as those listed above, and for students studying toxicology as part of their course in a range of different departments. It will be a three volume work, arranged thematically, and comprising approximately 3,000 pages. It will provide a comprehensive and in-depth review of the basic science of toxicology, its specialisations, and the application of toxicological knowledge. The proposed third edition differs from the second edition in that it contains new topic areas, and completely revised and restructured topics. In addition, a number of topics, no longer relevant, have been deleted and the table of contents and overall section structure has been substantially revised. The majority of articles are written at an advanced level, aimed at the sophisticated undergraduate, postgraduate and research scientist group, but it also contains overview articles, which aim to introduce the undergraduate student or a newcomer to the field. It will be used both as a resource for educational purposes and as a reference work for experienced researchers in the field.
All content will be published both in print, and electronically on Wiley InterScience. The Wiley InterScience publication will be a full MRW, as opposed to an o-book. We will investigate possible clustering opportunities with other InterScience publications, such as Pattys Toxicology
Justification for the new edition:
[1] In the seven years that have elapsed since the publication of the second edition of GAT there has been new information developed in the areas of both the fundamental and applied (practical) aspects of toxicology. Also, there has been the emergence, or clearer definition, of new areas of research and development in toxicology and of approaches to interpretive toxicology.
[2] There has been a considerable increase in the generation and development of more fundamental information and its applications, refinement or expansion of technical methods, clear advances in mechanistic toxicology, and greater interest in areas of toxicology previously regarded as somewhat speculative, of questionable relevance, or of limited scope.
[3] There have been evolving and changing approaches to several methodological, interpretative, regulatory, and ethical aspects of basic and applied toxicology.
[4] There has, over the past 5 or so years, been a greater public and media interest in toxicology because of the health, social, medicolegal and political implications of exposure to toxic substances. Hence, general and comprehensive texts on toxicology are being increasingly consulted by general physicians and lawyers, law enforcement agencies, information resource facilities, and members of the general public.
[5] It is clear that there are several areas of, and approaches to, toxicology which are now current and that were not listed as such in the contents of GAT 2e.
The third edition contains new chapters on current concepts in nanotoxicology; cell proliferation; oxidative stress; gap junctions in the toxic response; structure-activity relationships and predictive toxicology; factors regulating toxicity; influence of temperature on toxicity; haematotoxicology; toxicogenomics; genetic screening for susceptibility to xenobiotics; chemical pollution, ozone depletion, and meterological consequences; risk assessment of chemicals; poison control centres contributions to basic and applied toxicology; toxicology of biocides; toxic hazards in healthcare institutions; poisons of plant origin; toxicology of substances of addiction (social poisons). Additional key topics include: human volunteer studies; neurotoxicity, the carcinogenity of toxic compounds; toxic waste; regulation of industrial chemicals; chemical terrorism, radiation toxicology; regulation of pharmaceuticals.
The work consists of self-contained, peer-reviewed articles written by leading scientists in each field. It features overview articles aimed at undergraduates and non-specialists, which provide basic information and provide entry into the following advanced articles. These advanced articles are written for postgraduate students and research workers, containing detailed information and key references allowing the reader to investigate a specific area in more depth. This format allows professionals to use the books as a quick reference source.
The articles are thematically arranged into major sections:
- BASIC SCIENCE.
- MOLECULAR AND CELLULAR ASPECTS OF TOXICOLOGY.
- FACTORS INFLUENCING TOXICOLOGY.
- METHADOLOGY.
- TOXCICITY BY ROUTES.
- TARGET ORGAN AND TISSUE TOXICITY.
- GENETIC TOXICOLOGY, ONCOGENESIS, DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY.
- ENVIRONMENTAL AND ECOTOXICOLOGY.
- SPECIALIZATION.
- ISSUES RELEVANT TO TOXICOLOGY.
- MILITARY AND HOMELAND SECURITY TOXICOLOGY.
- TOXICOLOGY OF SPECIAL GROUPS OF SUBSTANCES
- TOXINOLOGY.
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