|
|
 |
|
Viewing report
|
|
|
|
Evaluation of Drug Candidates for Preclinical Development: Pharmacokinetics, Metabolism, Pharmaceutics, and Toxicology
John Wiley and Sons Ltd, Jan 2010, Pages: 289
Emphasizes the integration of major areas of drug discovery and their importance in candidate evaluation
It is believed that selecting the 'right' drug candidate for development is the key to success. In the last decade, pharmaceutical R&D departments have integrated pharmacokinetics and drug metabolism, pharmaceutics, and toxicology into early drug discovery to improve the assessment of potential drug compounds. Now, Evaluation of Drug Candidates for Preclinical Development provides a complete view and understanding of why absorption-distribution-metabolism-excretion-toxicology (ADMET) plays a pivotal role in drug discovery and development.
Encompassing the three major interrelated areas in which optimization and evaluation of drug developability is most critical - pharmacokinetics and drug metabolism, pharmaceutics, and safety assessment - this unique resource encourages integrated thinking in drug discovery. The contributors to this volume:
- Cover drug transporters, cytochrome P-450 and drug-drug interactions, plasma protein binding, stability, drug formulation, preclinical safety assessment, toxicology, and toxicokinetics
- Address developability issues that challenge pharma companies, moving beyond isolated experimental results
- Reveal connections between the key scientific areas that are critical for successful drug discovery and development
- Inspire forward-thinking strategies and decision-making processes in preclinical evaluation to maximize the potential of drug candidates to progress through development efficiently and meet the increasing demands of the marketplace
Evaluation of Drug Candidates for Preclinical Development serves as an introductory reference for those new to the pharmaceutical industry and drug discovery in particular. It is especially well suited for scientists and management teams in small- to mid-sized pharmaceutical companies, as well as academic researchers and graduate students concerned with the practical aspects related to the evaluation of drug developability.
Product samples
A sample for this product is available. Please Login/Register to download this sample.
Customers who bought this item also bought
Personalized Medicine - Scientific and Commercial Aspects
Accelerating Lead Generation: Emerging Technologies and Strategies
Commercial Opportunities from Biomarkers: Transforming drug discovery, clinical development and molecular diagnostics
Enzyme Inhibition in Drug Discovery and Development: The Good and the Bad
Early Stage Drug Safety Strategies and Risk Management: Maximizing Opportunities Towards Achieving Clinical Success
Biomarkers in Drug Discovery - Earlier Usage of Biomarkers in Optimization Stage to Reduce Drug Attrition Rate Significantly
Drug Metabolism Handbook: Concepts and Applications
Future Outlook of China Preclinical and Toxicology Outsourcing
Comprehensive Toxicology. Edition No. 2
Applications of Microdialysis in Pharmaceutical Science
|
|
|
|
