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Delivery Technologies for Biopharmaceuticals: Peptides, Proteins, Nucleic Acids and Vaccines
John Wiley and Sons Ltd, Nov 2009, Pages: 442
Advances in biotechnology have provided scientists with an increasing number of biopharmaceuticals such as novel peptide and protein drugs as well as nucleic acid based drugs for gene therapy. However, successful delivery of these biopharmaceuticals is a major challenge because their molecular properties lead to poor physical and chemical stability in the body and limited membrane permeability. Therefore researchers are developing a range of new delivery technologies and materials to enable these new drugs to be delivered intact to their target sites.
Delivery Technologies for Biopharmaceuticals describes strategies to overcome the main barriers for successful delivery of therapeutic peptides, proteins, and nucleic acid-based drugs or vaccines related to the site of administration and the target site. Many of the approaches described are reported in formulations in current clinical trials as well as in marketed products. Contents include:
- challenges in delivery of biopharmaceuticals
- novel formulation approaches for peptide and protein injectables
- novel non-injectable formulation approaches of peptides and proteins
- chemical vectors for delivery of nucleic acid based drugs
- viral technology for delivery of nucleic acids
- the innate immune response, adjuvants and delivery systems
- solid lipid nanoparticle based systems for delivery of biomacromolecule therapeutics
- dendrimers in delivery of biopharmaceuticals
- modification of peptides and proteins
- nanocarriers for the delivery of peptides and proteins
- polymer-based delivery systems for oral delivery of peptides and proteins
- advanced pulmonary delivery of peptide/protein drugs using polymeric particles
- polymer microparticles for nucleic acid delivery
- pulmonary delivery of small interfering RNA for novel therapeutics
- lipid-based formulations for siRNA delivery
- cellular bioavailability of peptide nucleic acids (PNA) conjugated to cell penetrating peptides
- DEAE-Dextran-MMA graft copolymer for non-viral delivery of DNA
- liposomes in adjuvant systems for parenteral delivery of vaccines
- influenza virosomes as delivery systems for antigens
- GRAZAX: an oromucosal vaccine for treating immunotheraphy against grass pollen allergy
- delivery technologies for biopharmaceuticals: a critical assessment
Delivery Technologies for Biopharmaceuticals is an essential single-volume introduction to the technologies used by researchers to ensure efficient delivery of this exciting new class of drugs. It will be of value to researchers and students working in drug delivery, formulation, biopharmaceuticals, medicinal chemistry, and new materials development
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