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Metals in Medicine
John Wiley and Sons Ltd, Nov 2009, Pages: 334
Metals in Medicine is a textbook directed at senior undergraduates and beginning graduate students, which describes metal-based agents for treating and diagnosing disease. Opening chapters present basic bonding concepts that are applicable to metallo-drugs and their biological targets, interactions that exist between the agents and substances in the biological milieu, basic pharmacokinetic and pharmacodynamic properties including transport and uptake of drugs by the cells, and methods for measuring efficacy and toxicity of agents. The steps from drug discovery to market place are also briefly outlined and discussed. These chapters lay the groundwork, in order that students can clearly understand how agents work, whatever their subject background.
Following this introduction, chapters focus on individual metallo-drugs and agents for treating and detecting disease, their synthesis, structure and general properties, known mechanism of action and important physical and chemical principles that apply. Topics covered include cisplatin; platinum anticancer drugs; ruthenium, titanium, and gallium for treating cancer; gold compounds for treating arthritis, cancer, and other diseases; vanadium, copper, and zinc in medicine; metal complexes for diagnosing disease; and metalsi in nanomedicine.
Throughout the book, Feature Boxes expand on features of drugs that are not directly related to studying metals in medicine, for example discovery, medical use, specialist assays, and metals in biology. At the end of the chapters there are specifically designed problems/exercises that apply basic kinetic, thermodynamic and chemical principles to practical problem solving in metals in medicine.
Metals in Medicine distills the essence of this important topic for undergraduate and graduate students in chemistry, biochemistry, biology and the related areas of biophysics, pharmacology, and bioengineering, and for researchers in other fields interested in getting a general insight into metals in medicine.
Features:
- covers all aspects of medicinal inorganic chemistry in a single text. Usually this important topic is fragmented across several chapters of larger bioinorganic chemistry books
- extensive references and bibliography to point the way to further information
topics are organized in a way that appeals to those new to the subject, with an introduction to important underlying themes and concepts followed by a focus on the application of individual metallo-drugs
- “Feature Boxes” appear thoughout the text. These expand important concepts in metals in medicine, providing sufficient information to see “how things work” with additional information being found in the sources at the end of the feature box and the extensive list of references at the end of the chapter.
- Following each chapter are specifically designed questions, with solutions, that allow the student to apply the laws of thermodynamics and the principles of equilibrium and kinetics to problem solving in the topic being addressed.
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