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Introduction to Proteomics: Principles and Applications


Description: A world-class, concise guide to all things proteomics

This book provides a highly authoritative introduction to the promising and fast-advancing field of proteomics, examining the role proteomics plays in the study of biological systems in general and disease in particular. It helps readers understand the structure, function, and interactions of proteins and how this knowledge is used for identify-ing diseases and developing new drugs.

Nawin Mishra, a world-renowned speaker and leader in proteomics studies who has worked with the late Nobel Laureate E. L. Tatum when proteomics was in its infancy, offers an expert perspective on the entire field, including:

- Easily accessible overview of the principles of proteomics

- Coverage of real-world, cutting-edge medical applications, including personalized medicine

- Clear guidelines on how to operate the complex instrumentation involved in proteomics

- Discussion of the future of proteomics

Complete with handy study questions and assuming only a basic understanding of biology, Introduction to Proteomics is an invaluable reference for novices and research scientists alike.

"For undergraduate and graduate biology and non-biology students and new researchers, Mishra (molecular genetics and genomics, U. of South Carolina) introduces the field of proteomics and its role in the study of biological systems and disease." (Book News, September 2010)


Contents: Chapter 1 Historical perspectives.

1.1 Introduction to Proteomics.

1.2 Proteome and Proteomics.

References.

Chapter 2 Proteomics - relation to Genomics, Bioinformatics.

2.1 Genomics and Functional Genomics and their utilization in Proteomics.

2.2 Bioinformatics and Computational aspects of Proteomics.

References.

Chapter 3 Methodology.

3.1 Separation of proteins- via a multidimensional approach.

3.2 Determination of the protein structure.

3.3 Determination of the amount of proteins.

3.4 Structural and Functional Proteomics.

References.

Chapter 4 Proteomics of Protein Modifications.

4.1 Phosphorylation and phosphoproteiomics.

4.2 Glycoproteins and glycoproteiomics.

4.3 Ubiquitination and ubiquitinomics.

4.4 Miscellaneous modifications of proteins.

References.

Chapter 5 Proteomics of Protein-Protein interactions /Interactomes.

5.2 In vitro Analysis of Protein Interactions.

5.3 In Silico analysis of Protein-Protein Interactions - Rosetta Stone and other computational analyses.

5.4 Synthetic Genetic method to determine Protein-Protein Interactions.

5.5 Interactomes.

5.6 Evolution and Conservation of Interactomes.

5.7 Interactome and complexity of organism.

5.8 Interaction of proteins with small molecules.

References.

Chapter 6 Applications.

I Application of Proteomics in Medicine: Proteomics, Human Disease and Medicine.

6.1 Diseasome.

6.3 Clinical Proteomics.

6.4 Meta Proteomics and Human Health.

II. Application of Proteomics in Biotechnology, Industry & others.

6.5 Biotechnology & Industry of Drug Production.

6.6. Metaproteomics of Microbial Fermentation.

6.7 Beef Industry.

6.8. Bioterrorism & Bio-defense.

References.

Chapter 7 Proteomics - Future.

7.1 Technical Scope of Proteomics - Beyond Protein Identification.

7.2 Scientific scope of Proteomics- Control of Epigenesis.

7.3 Medical Scope of Proteomics.

7.4 Proteomics, Energy Production and bioremediation.

7.5 Proteomics and Biodefense.

References.


Author NAWIN C. MISHRA, PhD, is an Emeritus Professor of Molecular Genetics and Genomics at the Department of Biological Sciences at the University of South Carolina. Professor Mishra has also served as a scientific consultant to the FAO of the United Nations, as Chairman of the Program Committee of the Genetics Society of America, and on the review panel of the Human Genome Project for the United States DOE. Professor Mishra has published over sixty articles in prominent research journals, including Nature, the Proceedings of the United States National Academy of Sciences, and Genetics.


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