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Epigenetics: Tools, Diagnostics, Drugs and World Market

Takeda Pacific, August 2010, Pages: 150

This broad and high-level report examines the emerging epigenetics market. This world market includes important biomedical product areas that will have a powerful impact on healthcare delivery and personalized medicine. This business report analyzes key market segments such life science research tools, diagnostics and therapeutics.

Many people already know about DNA, genes and the human genome. The DNA code defines the structure of who we are, our potential health and our characteristics that we pass on to our children. Epigenetics refers to the second code of life and links environmental impacts to a person’s health. Epigenetic mechanisms signal how and when genes are activated or silenced.

This research study discusses the market for life science tools and technologies that support epigenetics R&D. The report discusses important technologies, equipment and consumables including microarray, next-generation sequencing, PCR and other platforms. Topics such as microRNA and human stem cells are lightly covered.

The report covers subjects including important epigenetic factors including DNA methylation, histone modifications and others. The study discusses epigenetic biomarkers, commercial diagnostics and therapeutics that will foster personalized medicine. The study highlights new epigenetic diagnostics. This research examines the current epigenetic therapeutics on the market and drugs in the clinical pipeline. The report highlights major government grant initiatives such as the NIH’s ‘Roadmap Epigenomics Program’ initiatives, the EU’s ‘Epigenetic Network of Excellence’ and others.

This study discusses important epigenetics topics and provides the reader with key findings. The data estimates that the worldwide epigenetics market value will reach multi-billions of dollars in 2010, with a strong double-digit growth rate. This report reviews the activities of 35 companies. The study uses 39 figures and tables to illustrate the findings. This study includes many valuable tables that help the reader scan the details of major trends, market segmentation, forecast, M&As, partnerships, grant funding, patents and so on.

This must-have report would benefit people with job titles including CEO, VPs, Director of Business Development, Research Directors, Entrepreneurs, Venture Capitalists, Investment Planners, Research Scientists, Consultants or Industry Analysts

1. The Epigenetics Market Landscape
- Epigenetics for R&D, Diagnostics & Therapeutics
- Brief History
- Understanding Epigenetic Mechanisms
- Epigenetics, Key Diseases and Demographics
- Tools & Technologies for Epigenetic R&D
- Epigenetic Diagnostic Tests
- Epigenetic-Based Therapeutics
- Key Business Applications
- Academic Research Applications
- Diagnostic Applications
- Therapeutic Applications

2. Major Alliances, M&As and IP
- Major Alliances and M&As In Epigenetics
- Definitions of Deal Types
- Summary of Major Epigenetics Alliances and M&As
- Alliance and M&A Data Tables
- Patents, Business Development and Challenges
- Highlights of Companies That Own IP Involving Epigenetic Techs.
- Valuations of Epigenetic Technologies and Products
- Business Development Challenges
- Patent Challenges

3. Epigenetics Market Forecast
- Epigenetics Product Market Size, 2008~2013
- Epigenetic Market by Product Segments
- Epigenetic R&D Tools and Technologies Segments
- Epigenetic Diagnostics Segments
- Epigenetic Therapeutics Segments
- WW Epigenetic Market By Vendor Product Shares, 2008 & 2013
- Market by Major Diseases
- Cancer Segment
- Neuro-psychological (CNS) Segment
- Infectious Disease Segment
- Respiratory Segment
- Reproductive Disease Segment
- The ‘Others’ Segment
- Epigenetic Market by R&D Developer Segments
- Academic/Gov. Basic Life Science R&D Sub-segments
- Diagnostics Developer Segments
- Pharma/ Biotech Rx/Tx Developer Segments
- Epigenetics Market by WW Regions
- North America
- Europe
- Japan/ Asia Pacific
- ROW

4. Selected Companies Working in Epigenetics
- 454 Life Sciences (Roche)
- Abcam plc
- Active Motif, Inc.
- Affymetrix, Inc.
- Agilent Technologies, Inc., BAM/LS
- Applied Biosystems Group
- AVIVA Systems Biology
- BioServe
- Cogenics (Clinical Data)
- DNASTAR, Inc.
- Epigenomics AG
- Epigentek, Inc.
- Epiontis GmbH
- Fluidigm Corporation
- GATC Biotech AG
- GeneGo, Inc.
- Genomatix Software GmbH
- GenomeQuest, Inc.
- Genpathway, Inc.
- Human Genetic Signatures Pty. Ltd.
- Illumina, Inc.
- Invitrogen
- Methylgene, Inc.
- MGI Pharma, Inc. (subsidiary of Eisai)
- Millipore
- OncoMethylome Sciences SA
- Orion Genomics LLC
- Qiagen N.V.
- Regulus Therapeutics LLC
- Roche Nimblegen
- Rubicon Genomics, Inc.
- Sequenom
- SeqWright, Inc.
- Sigma-Aldrich Co.
- Zymo Research Corp.

5. Findings and Conclusions
- Epigenetics Market Future Direction
- Analytical Tools for Epigenetic R&D
- Commercial DNA Microarrays, ChIP on Chip and Methylation
- High-Throughput Sequencing and ChIP-Seq.
- Other Front Runner Technologies
- Consumables & Reagent Kits
- Commercial Diagnostic/ Test Services
- Therapeutics Involving Epigenetics
- Epigenetics Market Drivers and Restraints
- The US NIH Roadmap Epigenomics Program Initiatives
- The European Union Epigenetics Initiative
- M&A Deals Have Helped Epigenetic Product Companies
- FDA Approved Epigenetic Diagnostics Have Reached the Market
- FDA Approved Epigenetic Therapeutics Have Reached the Market
- Potential Business Opportunities
- Opportunities for American and European Companies
- Epigenetic Diagnostics
- Consider Other World Regions for Cost Savings or New Customers
- Market into Asia for Business Opportunities
- Business Opportunities for Asian Companies

6. Appendix
- Epigenetics Glossary
- Company Contacts
- Selected Grant Recipients for Epigenetics or Epigenomic Projects
- About Takeda Pacific
- About the Authors

List of Tables:

Table 1. Epigenetics Disease Demographics
Table 2. Summary of Major Alliances and M&As, 2005 to Oct.- 2008
Table 3. Alliances and M&As Jan. to Oct. 2008
Table 4. Major Alliances and M&As - 2007
Table 5. Major Alliances and M&As - 2006
Table 6. Major Alliances and M&As - 2005
Table 7. Epigenetics Related US Patents Issued to Orgs., 2007 to Oct.- 2008
Table 8. Valuations of Major M&As Involving Epigenetics.
Table 9. Total WW Epigenetic Product Market Revenues, 2008-2013
Table 10. WW Epigenetic Market By Vendor Products $M
Table 11. Epigenetic R&D Tools & Technologies Sub-segments $M
Table 12. Epigenetic Diagnostics Sub-segments $M
Table 13. Epigenetic Therapeutics Sub-segments $M
Table 14. WW Epigenetic Market By Vendor Product Shares, 2008 & 2013
Table 15. WW Epigenetic Market By Leading Diseases $M
Table 16. Major Cancer Types Targeted in R&D and Shares
Table 17. WW Epigenetic Market By Developer Segments $M
Table 18. Academic/Gov. Basic Life Science R&D $M
Table 19. Diagnostics Developers
Table 20. Pharma/ Biotech Rx/Tx Developers
Table 21. WW Epigenetic Market By Regions $M
Table 22. High-Density Whole Genome Microarrays for Epigenetics
Table 23. High-Throughput DNA Sequencing For Epigenetics
Table 24. Other Technologies for Epigenetics
Table 25. Epigenetic Diagnostics Development Pipeline
Table 26. Therapeutics in Clinical Pipeline Involving Epigenetics
Table 27. NIH Roadmap Epigenomics Program Initiatives
Table 28. Glossary of Epigenetic Terms
Table 29. List of Company Contacts
Table 30. Selected NIH Grant Recipients and Epigenomic Projects

List of Figures:

Figure 1. The Epigenetic Market Ecosystem
Figure 2. Highlights of Epigenetic Mechanisms
Figure 3. Growing Number of PubMed Articles About Epigenetics
Figure 4. Total WW Epigenetic Product Market Revenues, 2008-2013
Figure 5. WW Epigenetic Market By Vendor Products $M
Figure 6. WW Epigenetic Market By Product Market Shares, 2008 & 2013
Figure 7. WW Epigenetic Market By Major Diseases $M
Figure 8. WW Epigenetic Market By Developer Segments $M
Figure 9. WW Epigenetic Market By Regions $M

- 454 Life Sciences (Roche)
- Abcam plc
- Active Motif, Inc.
- Affymetrix, Inc.
- Agilent Technologies, Inc., BAM/LS
- Applied Biosystems Group
- AVIVA Systems Biology
- BioServe
- Cogenics (Clinical Data)
- DNASTAR, Inc.
- Epigenomics AG
- Epigentek, Inc.
- Epiontis GmbH
- Fluidigm Corporation
- GATC Biotech AG
- GeneGo, Inc.
- Genomatix Software GmbH
- GenomeQuest, Inc.
- Genpathway, Inc.
- Human Genetic Signatures Pty. Ltd.
- Illumina, Inc.
- Invitrogen
- Methylgene, Inc.
- MGI Pharma, Inc. (subsidiary of Eisai)
- Millipore
- OncoMethylome Sciences SA
- Orion Genomics LLC
- Qiagen N.V.
- Regulus Therapeutics LLC
- Roche Nimblegen
- Rubicon Genomics, Inc.
- Sequenom
- SeqWright, Inc.
- Sigma-Aldrich Co.
- Zymo Research Corp.

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