Influenza Vaccines

Expert Reviews Ltd, April 2009, Pages: 135

Pandemics of infectious diseases have struck human race occasionally and left devastating consequences, including high mortality and psychological damage. Among them are influenza pandemics, namely the ‘Asiatic Flu’ (1889–1890), the ‘Spanish Flu’ (1918–1918), the ‘Asian Flu’ (1957–1958) and the ‘Hong Kong Flu’ (1968–1969). The recent H5N1 avian influenza virus that causes epidemics in poultry in many areas of the world has raised a severe concern of a potential human influenza pandemic.

Despite commercially available vaccines against influenza, what we currently lack is a human influenza vaccine that has high efficacy in protecting humans from an influenza pandemic and can be produced in large-scale inexpensively and easily.

This Special Focus Issue of the peer-reviewed journal Expert Review of Vaccines focuses on the development progress of human influenza vaccines preparing for the next human influenza pandemic. With the recent threat from the avian H5N1 virus to human health, it is justifiable to equip us as soon as possible with effective vaccines against future deadly influenza virus subtypes

EDITORIAL:
- Moving influenza vaccines forward
S Sambhara & I Stephenson

PERSPECTIVES:
- Seasonal influenza vaccines: evolutions and future trends
AS Monto & SE Ohmit

- Progress with human H5N1 vaccines: a perspective from industry
B Palache & R Krause

REVIEWS:
- Increasing influenza vaccination coverage in recommended population groups in Europe
PR Blank & TD Szucs

- Influenza virus-like particle vaccines
JR Haynes

- Candidate influenza vaccines based on recombinant modified vaccinia virus Ankara
GF Rimmelzwaan & G Sutter

- Baculovirus vector as a delivery vehicle for influenza vaccines
F He, S Madhan & J Kwang

- Adenovirus as a carrier for the development of influenza virus-free avian influenza vaccines
DC Tang, J Zhang, H Toro, Z Shi & KR Van Kampen

- Emulsion-based adjuvants for influenza vaccines
FR Vogel, C Caillet, IC Kusters & J Haensler

- Using plant cells as influenza vaccine substrates
JA Chichester, LR Haaheim & V Yusibov

- Universal M2 ectodomain-based influenza A vaccines: preclinical and clinical developments
M Schotsaert, M De Filette, W Fiers & X Saelens

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