Tuberculosis (TB) is a contagious disease that is currently estimated to affect one-third of the world's population.
Many of today's TB therapeutics have been on the market for some time and require long and demanding treatment schedules, whose inconsistent nature often results in drug resistance. The occurence of multi and extensively drug-resistant TB (MDR-TB and XDR-TB) along with the growing number of patients with TB/HIV co-infection mean that there has never been more pressure to produce potent and safe therapeutic agents faster and more efficiently.
This Special Focus Issue of the peer-reviewed journal Future Mediicnal Chemistry provides a comprehensive, forward-looking overview of topical themes and recent advances in the identification of novel targets as well as the discovery and design of potential antiTB compounds.
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