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Induced Pluripotent Stem Cells
Future Medicine Ltd, July 2010, Pages: 122
Human iPS cells were first produced in 2007, when it was discovered that skin cells could be reprogrammed by the addition of just four genes. The discovery was received with huge interest both from researchers and the media, offering a potential alternative to costly and sometimes controversial embryonic stem cell research. Despite this enthusiasm, the fact that iPS cells were created via genetic engineering of the cell using viral vectors rendered them unsafe for any potential therapeutic use.
However, research in the field has progressed at breakneck speed. Several methods were quickly developed to deliver transcription factor genes without viral vectors and in April 2009 the first iPS cells were generated with no genetic alteration.
Debate still continues as to whether iPS cells are truly equivalent to ESC cells, with recent advances suggesting that cells can be reprogrammed directly from one cell type to another without an intermediate iPS cell step.
With the field moving so fast and a great deal of excitement being generated, authoritative reviews are needed to identify the genuine scientific advances amongst the hype, and offer expert commentary as to which approaches are likely to constitute the future of this field.
Bringing together experts from research, biotech and big pharma, this Special Focus Issue of the peer-reviewed journal Regenerative Medicine will aim to shed light on the real potential of iPS cells as an alternative to embryonic stem cells in research and clinical applications.
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