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The Global Market for Orthobiological Products

  • ID: 1309814
  • August 2010
  • Region: Global
  • 124 Pages
  • Espicom Business Intelligence Ltd

The global orthobiologics market was worth nearly US$3.1 billion in 2009 and experienced 7.3% growth compared with 2008 levels. However, safety concerns in some product areas, compounded by the pressure of the economic downturn, could create fundamental changes to the success of technologies and companies active in the area.

Growth is currently being driven by the increased awareness and adoption of orthobiologics, technological advancements and higher numbers of orthopaedic-related procedures being undertaken globally. Demographic factors such as the ageing population are the main driver of the higher number of orthopaedic procedures being undertaken. As well as leading to more orthopaedic procedures, the ageing population also means orthopaedic patients often have poor bone stock or osteoporosis. This in turn means more patients are requiring a bone graft substitute as they are unsuitable for autograft.

Other growth drivers include the rising numbers of obese patients with increasing levels of osteoarthritis and the resulting need for cartilage repair procedures. In addition, increasing numbers of patients have diabetes, which can lead to slower natural bone and soft READ MORE >

Note: Product cover images may vary from those shown



Comparison of Currently Available Orthobiologic Products

Fig.1: Global Musculoskeletal Market, 2009 US$32.5 billion
Fig.2: Global Orthobiologics Market by Product Application, 2009
Bone Grafting
Fracture Repair
Spinal Surgery
Revision Hip and Knee Replacement
Soft Tissue Repair
Cartilage Repair and Regeneration
Tendon and Ligament Repair

Selected Manufacturers' Orthobiologics Sales, 2005-2010 (US$ million)
Selected International Manufacturers' Orthobiologics Sales, 2004-2009 (million)
Fig.3: Global Orthobiologics Market Shares by Company, 2009
Industry Consolidation

Fig.4: Global Orthobiologics Market by Product Type, 2009
Regional Perspective
Fig.5: Global Orthobiologics Market by Geographic Region, 2009
Regulatory Environment
Orthobiologic Products: Regulatory Environment

Orthobiologics: Market Drivers, Restraints & Future Opportunities
Orthobiologics Market by Product Type, 2008-2015 (US$ million)
Global Orthobiologics Market Growth by Product, 2009-2015 (%)
Fig.6: Global Orthobiologics Market, 2008-2015(E) (US$ million)
Fig.7: Global Orthobiologics Market by Product Type, 2015 (E)


Advantages of Allografts
Limitations of Allografts
Regulation and Safety Standards
The Musculoskeletal Allograft Market
Fig.8: Global Allograft Market, 2008-2015(E) (US$ million)
Key Providers of Allografts
Interventional Spine's RENEW Interspinous Allograft Technology
LifeNet Health
Musculoskeletal Transplant Foundation
Osteotech's Allografts
Fig.9: Osteotech: Allograft Sales, 2005-2009 (US$ thousands)
FacetLinx Spinal Allograft Implant
RTI Biologics' Allografts
Fig.10: RTI Biologics: Allograft Sales, 2005-2009 (US$ thousands)
Spinal Allograft
RTI Biologics: Spinal Allograft Portfolio and Distributors
Sports Medicine Allograft
General Orthopaedic Allografts
Advanced Technologies
NuVasive's Osteocel Plus
Orthofix' Trinity Evolution Viable Cryopreserved Cellular Bone Matrix

Fig.11: Global DBM Market, 2008-2015(E) (US$ million)
DBM Regulatory Requirements
DBM Product Highlights
Competitive Landscape: Demineralised Bone Matrix Products
Alphatec Holdings' DBM Products
B Braun/Aesculap's ProSpace DBM-D
ETEX' EquivaBone
Integra LifeSciences' Accell DBM Products
Integra LifeSciences' OsteoSparx and OsteoSurge
Integra LifeSciences' Trel-X and Trel-XC
Osteotech's Grafton DBM
Fig.12: Osteotech: DBM Sales, 2005-2009 (US$ thousands)
Osteotech's Synthetic and Hybrid Bone Grafts
Fig.13: Osteotech: Hybrid/Synthetic Bone Graft Sales, 2005-2009 (US$ thousands)
Osteotech's MagniFuse Bone Graft
Osteotech's Plexur Products
RTI Biologics' DBM-Based Bone Substitutes
RTI Biologics: Bone Substitute Allograft Paste Portfolio and Distributors
Fig.14: RTI Biologics: DBM Bone Substitute Sales, 2005-2009 (US$ thousands)

Fig.15: Global Synthetic Bone Substitute Market, 2008-2015(E) (US$ million)
Competitive Landscape: Synthetic Bone Substitutes
Product Highlights
ApaTech/Baxter's Actifuse and ApaPore
Alphatec/Scient'x' Bone'X
Biocomposites' geneX Products
Biocomposites' Allogran-N
Bone Solutions' OsteoCrete Bone Void Filler
BoneSupport's Cerament Products
curasan's Osbone
curasan's Cerasorb
DePuy's Healos
ETEX' Nanocrystalline-Based Products
Stryker's Bio MatrX Structure and Bio MatrX Generate
Graftys' Synthetic Bone Substitutes
Integra LifeSciences' Integra Mozaik Bone Substitutes
Integra LifeSciences' OsteoStrux Osteoconductive Scaffold
Integra LifeSciences' Integra OS Osteoconductive Scaffold
ISTO Technologies' InQu Bone Graft Extender and Substitute
Medtronic/Kensey Nash's MasterGraft Products
Orthovita's Orthobiologic Products
Vitoss Bone Graft Substitutes
Cortoss Bone Augmentation Material
Wright Medical's Pro-Stim Injectable Osteoinductive Bone Graft Substitute
Products in Development
Kuros Biosurgery's Synthetic Bone Healing Products
GenOsteo's Bone-Like Scaffolds
Orthox' Spidrex Bone
PolyNovo Biomaterials' Novosorb
RepRegen's StronBone

Competitive Landscape: Soft Tissue Repair Implants
DePuy's Restore Orthobiologic Soft Tissue Implant
Collagen-Based Products
Collagen Matrix' TenoMend Collagen Tendon Wrap
LifeCell's Conexa Reconstructive Tissue Matrix
Synovis Life Technologies' OrthADAPT Products
Wright Medical's GraftJacket Matrix
Wright Medical's Biotape XM Reinforcement Matrix
Dermal Matrix Products
Musculoskeletal Transplant Foundation's Allopatch HD Acellular Human Dermis
Synthetic and Combination Products
Artimplant's Artelon Implants
Resurfacing Concept
Reinforcement Concept
Kensey Nash's Cartilage Repair Device
Orteq's Actifit
Products in Development
Biomet's ChonDux
Kensey Nash/Arthrex Collaboration
MiMedx'CollaFix Products
Orthox' Spidrex Cartilage Technology
Osteotech's Human Collagen Technology
TiGenix' Chondromimetic
Tissue Regenix' dCELL Meniscus

Fig.16: Global Market for Growth Factors, 2008-2015(E) (US$ million)
Bone Morphogenetic Proteins
Current Challenges for BMP Products
Medtronic's Infuse Bone Graft
Medtronic's InductOs
Stryker's OP-1
Products in Development
Medtronic's AMPLIFY rhBMP-2 Matrix
Scil Technology's ST01 rhBMP Growth Factor Product
Platelet-Derived Growth Factors
BioMimetic Therapeutics' Augment Bone Graft
Augment Clinical Trial and Safety Data
Augment Injectable Bone Graft
Augment for Sports Medicine
Cerapedics' i-FACTOR Peptide Enhanced Bone Grafts
Products in Development
Bone Biologics' NELL 1 Protein (UCB-1)
Cardium Therapeutics' Gene Activated Matrix Technology
Future Developments
Johnson & Johnson's Intradiscal rhGDF-5
Merck Serono's FGF-18
Scil Technology's rhCD-RAP-Based Products
TissueGene's TissueGene-C

Fig.17: Global Cell-Based Orthobiologics Market, 2008-2015(E) (US$ million)
Regulatory Environment
EU Advanced Therapy Medicinal Products
Autologous Platelet Separation and Concentration Products
Arteriocyte Medical Systems' Magellan Autologous Platelet Separator System
FDA Warning Letter
Biomet's Platelet Separation Products
Cytomedix' Angel Whole Blood Separation System
Emcyte/Exactech's Accelerate Platelet Concentrate Products
Harvest Technologies' SmartPrep 2 Systems
Musculoskeletal Transplant Foundation's Cascade Autologous Platelet System
Smith & Nephew's Caption Disposable Platelet Concentration System
Autologous Chondrocyte Transplantation
Current Market Limitations
B Braun's Novocart 3D Autologous Chondrocyte Transplantation
co.don's Autologous Cell Therapies
Fig.18: co.don: Product Sales, 2005-2009
Fig.19: co.don: Cell Transplants by Region, 2009
Fig.20: co.don: Cell Transplants by Product, 2009
Fidia Advanced Biopolymers Hyaluronan-Based Tissue-Engineered Cartilage
Geistlich's Chondro-Gide
Genzyme's Carticel Cell Therapy and MACI
ProCon Biotech's BioCart System
TiGenix' ChondroCelect
Products in Development
Histogenics' NeoCart Implant
TiGenix' Cell-Based Technologies
Living Cartilage Implants
ISTO Technologies/Zimmer's DeNovo NT Natural Tissue Graft
ISTO Technologies/Zimmer's DeNovo ET Living Cartilage Implant
ISTO Technologies' NuQu Injectable Cell-Based Therapy
Stem Cell Technologies
Autologous Bone Marrow Concentration Products
Biomet's BioCUE Platelet Concentration System
Emcyte's GenesisCS and Sequire Systems
Emcyte/Exactech's Accelerate Bone Marrow Concentrate System
Harvest Technologies' SmartPReP 2 Bone Marrow Aspirate Concentrate System
ThermoGenesis' MXP MarrowXpress and Res-Q 60 BMC
Biosafe's Sepax Stem Cell Processing Products
Autologous Stem Cell Products - Mesoblast's Mesenchymal Precursor Cell Products
MPCs for Fracture Repair
Adipose Tissue Stem Cell Technology
Tissue Genesis
Allogeneic Stem Cell Therapies in Development
Alphatec Spine/Parcell Spine's ELA Stem Cell
Geron and University of Edinburgh - Human Embryonic Stem Cell Technologies
Mesoblast's NeoFuse for Spinal Fusion
Mesoblast's RepliCart for Knee Cartilage Repair
Mesoblast's MCSs for Degenerative Disc Disease
Osiris Therapeutics' Chondrogen
Osiris Therapeutics' Osteocel XC
TiGenix' Cell-Based Technologies
Progenteq's Progenitor Cell-Based Therapy

Kuros Biosurgery/Baxter's Bone Healing Products
Spinal Restoration's Biostat System



Note: Product cover images may vary from those shown
Note: Product cover images may vary from those shown


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