Long-Term Intervention in Chronic Obstructive Pulmonary Disease. Lung Biology in Health and Disease

Informa Healthcare, September 2004, Pages: 552

Reviewing current strategies and methods to treat and manage patients suffering with ventilatory dysfunction, this reference provides a critical overview of the epidemiology, pathophysiology, diagnosis, and outcomes of COPD-describing techniques to prevent and reduce the development of symptoms, improve patient quality of life, and slow the progression of disease.

Definition of Chronic Obstructive Pulmonary Disease. COPD: Worldwide Prevalence. Worldwide Mortality from COPD. Risk Factors for the Development of COPD. Risk Factors for the Progression of COPD. Socioeconomic Burden of COPD. Pathology of COPD. Inflammatory Mechanisms. Defective Repair in COPD: The American Hypothesis. Proteases in COPD. Oxidative Stress and COPD. Pathogenesis of Infections in COPD Patients. Extrapulmonary Effects of COPD. Smoking Cessation. Anticholinergics. Long-Acting Beta-Adrenoreceptor Agonists for the Treatment of COPD. The Role of Glucocorticosteroids in the Management of COPD. Antibiotics in COPD. Long-Term Intervention Studies: a1-Antitrypsin Substitution. Surgery and Transplantation for COPD. New Therapies for COPD.

Romain Pauwels University of Ghent, Belgium.

Dirkje S. Postma University of Groningen, The Netherlands.

Scott T. Weiss Brigham and Women's Hosptital, Boston, Massachusetts, USA.

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