- Language: English
- 364 Pages
- Published: December 2011
- Region: Global
Airway Remodeling. Lung Biology in Health and Disease
- Published: January 2001
- Region: Global
- 328 Pages
- Informa Healthcare
This landmark volume discusses the characteristics and impact of the remodeling process on airway function and clinical disease expression within the airway in asthma, covering pharmacological therapies and possible future targets relevant to regulating the remodeling process.
Emphasizes the importance of treating underlying airway inflammation and the relevance of structural alterations to the airway wall, including glandular increases, enhanced collagen deposition within the submucosa, increased vasculature, smooth hypertrophy, and hyperplasias!
Tracing the development and maintenance of bronchial hyperresponsiveness, decline in lung function, and loss of reversibility evident in chronic asthma, Airway Remodeling
- describes the contribution of inflammatory cells in the development of airway structural changes
- examines how pharmaceutical agents act and whether existing treatments modify or prevent remodeling in chronically inflamed asthmatic airways
- considers whether neural pathways initiate as well as contribute to the airway inflammatory cascade that leads to remodeling
- reviews the action of cytokines and growth factors on ASM signaling
- outlines novel approaches to regulating smooth muscle growth
- clarifies whether permanent ventilatory incapacity in asthma is caused by the uncoupling of the airway and the role of the lung parenchyma
- details high-resolution computerized tomography scan to measure the internal size of the airway at baseline, during challenge, or after bronchodilatation
- and more!
Improving lung function and quality of life by reducing the need for emergency care, hospital admissions, and systemic steroid administration, Airway Remodeling is a superb reference for pulmonologists and respiratory system specialists; physiologists; pneumologists; allergists; pharmacologists; molecular, cellular, and lung biologists; and graduate and medical school students in these disciplines. SHOW LESS READ MORE >
What Does Airway Remodeling Mean? Its Relevance to Asthma
Jean Bousquet and Antonio Maurizio Vignola
How Can We Assess Airway Remodeling Using Imaging?
Dany Jaffuel, Fabrice Jean Paganin, and Jean Bousquet
The Use of Morphometry to Assess Airway Wall Remodeling in Asthma
Neil G. Carroll and Alan Lloyd James
Physiological Consequences of Lung Remodeling in Asthma
Consequences of Airway Remodeling to the Patient
Signaling Mechanisms That Regulate Airway Smooth Muscle Cell Function and Growth
Aili L. Lazaar and Reynold A. Panettieri, Jr.
The Bronchial Vessels in Airway Remodeling
John W. Wilson and Xun Li
The Extracellular Matrix of the Airways and Bronchial Asthma
William R. Roche
Role of the Airway Nervous System in Airway Remodeling
Tony R. Bai and Darryl A. Knight
The Influence of Pharmacological Therapy on Airway Remodeling in Asthma
Peter H. Howarth
The Human Eosinophil and Its Role in Airway Remodeling
Role of Macrophages in Airway Remodeling in Asthma: Future Therapeutic Target
Antonio Maurizio Vignola, Pascal Chanez, Liboria Siena, Rosalia Gagliardo, Gisele Mautino, Giovanni Bonsignore, Philippe Godard, and Jean Bousquet
Airway Smooth Muscle as a Target for Novel Antiasthma Drugs Acting on Airway Wall Remodeling
Alastair G. Stewart
Growth Factor-Extracellular Matrix Interactions in Bronchial Tissue in Asthma
Janis K. Shute
Is There an Animal Model of Airway Remodeling?
Johan C. Kips, Els Palmans, Nele Vanacker, and Romain A. Pauwels
Future Directions in Airway Remodeling
John W. Wilson and Peter H. Howarth
Peter H. Howarth University Medicine.
John William Wilson
Jean Bousquet Montpellier University, France.
Romain Pauwels University of Ghent, Belgium.