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Axonal Regeneration in the Central Nervous System
Informa Healthcare, Sep 2000, Pages: 736
Summarizing a review of research into factors that regulate, stimulate, and prevent regeneration in the central nervous system (CNS), this comprehensive reference progresses further into answering and resolving neuron capacity for axon regeneration in the mammalian CNS.
Axonal Regeneration in the Central Nervous System
- analyzes axonal regeneration, reinnervation, and functional recovery in lower vertebrates
- examines the correlation between developmental age and the ability to regenerate
- considers mammalian neuron responses at the cell body, site of injury, and in the distal nerve, including apoptic cell death, and inflammatory and glial responses to injury
- reviews genomic responses to axotomy with a comparative description of transcribed genes from successfully regenerating neurons and neurons incapable of regrowth
- discusses how growing axons may induce the expression of genes in glia/Schwann cells following axotomy and regeneration
- describes the use of gene therapy to deliver trophic and survival factors to injured neurons
- explores the hospitable environments of the peripheral nerve, olfactory ensheathing cells, and fetal cell transplants for regeneration
- discusses results from applications of fetal CNS tissue to human spinal cord injuries
- and much more!
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