- Language: English
- 381 Pages
- Published: October 2012
- Region: Global
Handbook of Carcinogenic Potency and Genotoxicity Databases
- Published: November 1996
- Region: Global
- 768 Pages
- Informa Healthcare
This unique new reference contains the Carcinogenic Potency Database (CPDB), which analyzes results of decades of animal cancer tests, including all Technical Reports of the National Toxicology Program (NTP) and the general published literature. A guide to the literature of animal cancer tests, the CPDB includes references to each published experiment and never-before published analyses.
For each of 5,000 long-term experiments on 1,300 chemicals, the user-friendly format includes data on the species, strain, and sex of the test animal; features of experimental protocol such as the route of administration, duration of dosing, dose levels, and duration of the experiment; histopathology and tumor incidence; the shape of the dose-response curve; published author's opinion about the carcinogenicity at each site; and reference to the original publication of the test results. In addition, a measure of carcinogenic potency, the TD50, its statistical significance and confidence limits, are given for each tumor site. An overview is provided of earlier publication updates, such as positivity rates, reproducibility, interspecies extrapolation, and ranking possible carcinogenic hazards.
The book also includes a summary of the NTP genetic toxicity test results on 1,500 chemicals, which are referenced to the original publications, including the Salmonella (Ames) test, L5178Y mouse lymphoma cell mutation test, chromosome aberration and sister chromatid exchange tests in cultured Chinese hamster ovary cells, and the sex-linked recessive lethal mutation test in Drosophila melanogaster.
An index with chemicals listed by CAS number allows cross referencing between the carcinogenicity and genotoxicity databases, making data easy to find. SHOW LESS READ MORE >
Carcinogenic Potency Database, L. Swirsky Gold, T.H. Slone, N.B. Manley, G. Backman Garfinkel, L. Rohrbach, and B.N. Ames
Methods for the Carcinogenic Potency Database
Guide to the Plot of the Carcinogenic Potency Database
Plot of Cancer Test Results
Appendices of Codes and Definitions
Carcinogenicity Bibliography - NCI/NTP Technical Reports
Carcinogenicity Bibliography - General Literature
Summary of Carcinogenic Potency Database by Target Organ, L. Swirsky Gold, N.B. Manley, and T.H. Slone
Summary of Carcinogenic Potency Database by Chemical, L. Swirsky Gold, T.H. Slone, and B.N. Ames
Summary of Chemical Carcinogenicity in Rats and Mice
Summary of Chemical Carcinogenicity in Hamsters
Summary of Chemical Carcinogenicity in Nonhuman Primates and Dogs
Overview and Update of Analyses of the Carcinogenic Potency Database, L. Swirsky Gold, T.H. Slone, and B.N. Ames
Genotoxicity Database, E. Zeiger
Description of Genotoxicity Tests
Table of Genotoxicity Results
Index of Chemical Names in the Carcinogenic Potency (CPDB) and Genotoxicity (GT) Databases by Chemical Abstract Service (CAS) Registry Number
Lois Swirsky Gold University of California.
Errol Zeiger NIEHS, Chapel Hill, North Carolina, USA.