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Hard Copy (Hard Back)
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Hard Copy (Hard Back)
Handbook of Drug Screening. Edition No. 2. Drugs and the Pharmaceutical Sciences
Informa Healthcare, June 2009, Pages: 504
Building upon the foundation of basics discussed in the previous edition, the Second Edition provides a more in-depth look at the latest methods and technologies of advanced drug screening, an essential function of drug discovery.
With extensively updated content and 21 new chapters, this text examines:
- quality and efficiency of drug target validation and potential drug compound selection
- reducing assay costs and improvement in assay technology
- data quality improvement
- trends in drug discovery
- how drug screening can minimize adverse drug effects
- recent advancements, including: high content screening; protein-protein interactions; high-throughput crystallization; lead optimization; chemoinformatics and microfluidics technologies; target validation by genomics, proteomics, and siRNA; structure-based drug design; automation; and medicinal chemistry
Trends in Drug Discovery. Screening Strategies and Infrastructure in Drug Discovery. Logistics in Progression of Compounds to Clinical Development. Assay Technologies in Drug Screening. Proteomics Technologies in Drug Discovery. GPCR Screens. Nuclear Hormone Receptor Screens. Emerging Novel HTS Technologies for Cell Based Assays. In vitro Strategies for Ion Channel Screening in Drug Discovery. Wheat from Chaff: General and Mechanistic Triage of Screening Hits for Enzyme Targets. Protein Kinases and Phosphatases. MicroRNA Strategies in Drug Discovery. Strategies for Screening Biological in Drug Discovery. Cryopreserved Cells in Functional Cell-Based HTS Assays. High Content Screening Assay development. ADME-TOX, PK and Drug Metabolism in Drug Discovery. Compound Management for Drug Screening. Practical Approach to Quantitative High-Throughput Screening. Enabling the Large Scale Analysis of Quantitative High Throughput Screening Data. Nanotechnology in Drug Discovery.
Ramakrishna Seethala Bristol-Meyers Squibb Company, Princeton, New Jersey, USA.
Litao Zhang Bristol-Meyers Squibb, Princeton, New Jersey, USA.
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