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Anticancer Drug Toxicity: Prevention, Management, and Clinical Pharmacokinetics
Informa Healthcare, April 1999, Pages: 576
Containing the latest findings on the toxicity of a wide range of chemotherapeutic agents, this up-to-the-minute reference offers expert analyses on the pharmacokinetic-pharmacodynamic and pharmacokinetic-toxicodynamic relationships of anticancer compounds.
Anticancer Drug Toxicity
- explores therapeutic drug monitoring (TDM) as a method of maximizing the efficacy, and minimizing the dangers, of chemotherapy
- presents a vast amount of clinical pharmacokinetic data on cytostatic drugs
- offers a comprehensive classification of toxicity patterns associated with the use of cytotoxic drugs
- analyzes the pharmacokinetics of alkylating agents, platinum compounds, anthracyclines, antimetabolites, semisynthetic podophyllotoxin- and camptothecin derivatives, mitotic inhibitors, and other cytotoxic agents
- highlights the pharmacogenetics of 6-mercaptopurine and its clinical significance
- explicates toxicity in relation to the lungs, kidneys, heart, and gonads
- examines disorders caused by asparaginase preparations
- reviews types of secondary malignancy such as leukemias, ovarian cancer, testicular cancer, breast cancer, secondary solid neoplasias, and Hodgkin's disease
- clarifies the understanding of toxicity as a crucial element in supportive management of cancer therapy
- and more!
An enormously practical guide for everyday clinical practice, as well as a source of inspiration for further research in the field, Anticancer Drug Toxicity is an invaluable reference for clinical and medical oncologists; hospital, industrial, and clinical pharmacologists and pharmacists; toxicologists; pharmaceutical chemists; radiologists; and graduate and medical school students in these disciplines.
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