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Dried Blood Spots Part 2 Product Image

Dried Blood Spots Part 2

  • ID: 1326072
  • November 2010
  • Region: Global
  • 179 Pages
  • Future Science Ltd

Dried blood spot (DBS) sampling involves spotting blood from a heel- or finger-prick onto a card which is then air dried and sealed in bags with desiccant for storage and shipping. The technique offers many advantages compared to traditional liquid blood or plasma samples including:

- Low blood volume requirements are beneficial in pediatric studies and enable serial bleeding from one animal, so reducing the number of animals used in studies
- Improved data quality in preclinical toxicokinetic and pharmacokinetic studies
- Less invasive and more patient-friendly than venous cannulation
- Cards can be stored at ambient conditions, reducing sample storage and transport costs

Although DBS has a long history of use in pediatric studies and in resource-limited settings, these advantages have generated significant current interest in DBS amongst bioanalysts, toxicologists, and pharmacokineticists who see the benefits of implementing DBS sampling in their drug development programs. Consequently, a large amount of research into the use of DBS is currently underway in pharmaceutical development laboratories worldwide.

The use of these samples can make life more READ MORE >

FOREWORD
- Neil Spooner
GlaxoSmithKline

COMMENTARY
- Pharmacokinetic considerations as to when to use dried blood spot sampling
Gary Emmons, Sanofi-Aventis & Malcom Rowland, University of Manchester

CONFERENCE REPORT
- EBF Workshop on Connecting Strategies on Dried Blood Spots-conference report
Philip Timmerman, Johnson and Johnson

EDITORIALS
- Increasing Efficiency for Dried Blood Spot Analysis: Prospects for Automation and Simplified Sample Analysis
Roger Pham, Amgen

- The application of Dried Blood Sampling in global clinical trials
Peter van Amsterdam, Abbott

REVIEW
- Dried blood spots in HIV monitoring: applications in resource-limited settings
Asgeir Johannessen, Oslo University Hospital, Ulleval

SPECIAL REPORT
- A powerful couple in the future of clinical biochemistry: the in situ analysis of Dried Blood Spot by Ambient Mass Spectrometry
Gaetano Corso, Medical Faculty of University of Foggia

RESEARCH ARTICLES
- Effect of Storage Conditions on the Weight and Appearance of Dried Blood Spot Samples on Various Cellulose Based Substrates
Phil Deniff
GlaxoSmithKline

- High sensitivity assay for the determination of zatebradine in dried spot of human blood at pg/mL level using HILIC chromatography tandem mass spectrometry
Marco Michi
GlaxoSmithKline

- Sensitive determination of a drug candidate in dried blood spots using a TLC-MS interface integrated into a column-switching LC-MS/MS system
Katja Heinig, Thomas Wirz & Almudena Gajate-Perez
Roche

- Development and Validation of an HPLC/MS/MS Method for the Analysis of Dexamethasone from Pig Synovial Fluid Using Dried Blood Spotting
Chad Christianson
Alturas Analytical

- Utility of Dried Blood Spot Sampling and Storage for Increased Stability of Photo-Sensitive Compounds
Chester L. Bowen, Matthew D. Hemberger, Jonathan R. Kehler, and Christopher A. Evans
GlaxoSmithKline

- Assay for screening 6 antimalarial drugs and one metabolite using dried blood spot sampling, sequential extraction and Ion trap detection
Niklas Lindegårdh and Daniel Blessborn
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

- Validation of Individual Quantitative Methods for the Determination of the Cytochrome P450 Probe Substrates Caffeine, Flurbiprofen, Midazolam, Omeprazole and Rosiglitazone in Dried Spots of Human Blood with HPLC-MS/MS Detection
Rakesh Lad
GlaxoSmithKline

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