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Therapeutic Strategies in Rheumatology

Therapeutic Strategies in Rheumatology offers a global perspective on current approaches to diagnosis and therapy for musculoskeletal and joint disease, reporting on the latest clinical trials and 'breaking news' that will have an impact on future treatment strategies. In this book, experts in each of these fields guide the reader through the many options now available to clinicians combating these diseases, providing a clear account of current best practice and possible future developments. It has been well reported in recent trials that early inflammatory arthritis responds well to prompt, aggressive treatment with biologics and combination therapy. In addition to anti-TNF, newer biological agents are now emerging that block other mediators of inflammation and damage, and continuing advances in pharmacogenetics permit individually tailored therapeutic regimes that balance efficacy and toxicity. Additionally, in osteoporosis, a bewildering array of therapeutic options is available – the challenge for the clinician is deciding on which is appropriate for each patient. Progress is also being made in understanding and treating the numerous complications concomitant with rheumatic disease, particularly pulmonary hypertension. This publication addresses these issues in-depth, and presents a valuable resource for clinicians to stay abreast of latest developments.


- Translates scientific evidence into improved clinical outcomes
- Provides doctors with comprehensive overview of new developments from bench to bedside
- Significant focus on disease mechanisms and emerging therapies in inflammatory arthritis


- Specialists in rheumatology and internal medicine
- Hospital pharmacists
- Doctors in training
Editor and Contributors

1. Early arthritis
Jackie Nam, Edith Villeneuve, Paul Emery

2. Established rheumatoid arthritis
Pieternella J. Barendregt, J. Mieke W. Hazes

3. Beyond anti-TNF: other biological drugs in inflammatory arthritis
Peter C. Taylor

4. Pharmacogenetics of inflammatory arthritis
Judith A. M. Wessels, Tom W. J. Huizinga, Henk-Jan Guchelaar

5. Psoriatic arthritis
Eliza Pontifex, Oliver Fitzgerald

6. Therapy of ankylosing spondylitis
Jurgen Braun

7. Systemic lupus erythematosus
Tim Y.-T. Lu, Jose M. Pego-Reigosa, David A. Isenberg

8. Antiphospholipid syndrome
Ann Scott-Russell, Christopher J. Edwards, Graham R. V. Hughes

9. Progress in the therapy of systemic sclerosis
Emma C. Derrett-Smith, Christopher P. Denton

10. Inflammatory myositis
David L. Scott

11. Disease-modifying drugs in osteoarthritis
Alexandra N. Colebatch, Nigel K. Arden

12. Management of gout
Edward Roddy, Michael Doherty

13. Osteoporosis
Ira Pande

Edited by:

Michael Doherty, Professor of Rheumatology, Academic Rheumatology, Nottingham City Hospital, Nottingham, UK
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