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Toxicology of the Nose and Upper Airways. Target Organ Toxicology Series
Informa Healthcare, February 2010, Pages: 450
Toxicology of the Nose and Upper Airways presents a culmination of knowledge as a result of both human and experimental animal studies over the past decade. The application of molecular biologic methods, recognition of neurogenic inflammatory processes, and utilization of genetic knockout animals are just some of the advances in toxicology of the upper airways in recent years. This book pulls all of this valuable research together, and includes:
- Contributions from internationally-recognized leaders in the fields of experimental toxicology, respiratory medicine, otolaryngology, allergy, and sensory science.
- Examines the effect of selected pollutants on the upper airways of both humans and experimental animals, while emphasizing mechanistic issues in the process.
- Epidemiologic findings from populations exposed occupationally or environmentally are reviewed, and alternative risk assessment approaches are compared and contrasted.
- Experimental data from both animal and human studies.
- Chapters organized into clear sections on structure and function, dosimetry and toxicokinetics, functional and pathologic responses and their measurement, responses to specific agents, risk assessment and special topics.
Toxicology of the Nose and Upper Airways is an essential reference for pharmacologists and toxicologists concerned with the nose and upper airway, as well as clinicians, risk assessors, and sensory scientists.
STRUCTURE & FUNCTION IN THE UPPER AIRWAY
1. Functional anatomy of the upper airway in experimental animals
James Wagner, Michigan State University
2. Functional anatomy of the upper airway in humans
Fuad M. Baroody, University of Chicago
3. Functional neuroanatomy of the upper airway in experimental animals
Wayne L. Silver & Paige Roe, Wake Forest University; C.J. Saunders, Univ. of Colorado
4. Functional neuroanatomy of the human upper airway
Murugan Ravindran, Samantha Jean Merck & James N. Baraniuk, Georgetown University
5. Mucosal enzymology of the upper airway
John B. Morris, Univ. of Connecticut & Dennis Shusterman, Univ. of Calif., San Francisco
DOSIMETRY & TOXICOKINETICS OF NASAL EXPOSURE
6. Upper airway dosimetry of gases, vapors and particulate matter in experimental animals
Julia Kimbell & Bahman Asgharian, Hamner Institutes
7. Upper airway dosimetry of gases and vapors in humans
Karla Thrall, Pacific NW Laboratory
8. Upper airway dosimetry of particulate matter in humans
Owen Moss, Hamner Institutes
FUNCTIONAL & PATHOLOGIC RESPONSES AND THEIR MEASUREMENT
9. Exposure and recording systems in human studies
Thomas Hummel, U. Of Dresden & Dennis Shusterman, Univ. of California, San Francisco
10. Biomarkers of nasal toxicity in experimental animals
Mary Beth Genter, University of Cincinnati
11. Biomarkers of nasal toxicity in humans
T.I. Fortoul, C.I. Falcón-Rodríguez, V. Rodríguez-Lara, N. López-Valdez, L.F. Montaño, M.C. Ávila-Casado & P. Mussali-Galante, National University of Mexico
12. Nasal reflexes - including alterations in respiratory behavior - in experimental animals.
John Morris, University of Connecticut
13. Nasal chemoensory irritation in humans
J Enrique Cometto-Muñiz & William S. Cain, University of Calif., San Diego; Michael H. Abraham, Ricardo Sánchez-Moreno & Javier Gil-Lostes, University College, London
14. Nasal reflexes in humans
Kathryn Sowerwine, Samantha Jean Merck & James Baraniuk, Georgetown University
15. Olfactory toxicity in humans and experimental animals
Pamela Dalton, Monell Chemical Senses Center
16. Inflammatory conditions of the nose and paranasal sinuses in experimental animals
Jack Harkema, Michigan State University
17. Inflammatory conditions of the nose and paranasal sinuses in humans
Ricardo Tan & Jonathan Corren, University of California, Los Angeles
18. Chronic tissue changes and carcinogenesis in the upper airway
Ruud Woutersen, TNO (Netherlands)
RESPONSES TO SPECIFIC AGENTS
19. Second hand tobacco smoke exposure in humans
Suzaynn Schick & Dennis Shusterman, University of California, San Francisco
20. Chlorine exposure in humans and experimental animals
Dennis Shusterman, Univ. of Calif., San Francisco & John B. Morris, Univ. of Connecticut
21. Hydrogen sulfide exposure in experimental animals
David Dorman and Melanie Struve, North Carolina State University
22. Sulfur dioxide exposure in humans
Jane Q. Koenig, University of Washington
23. Exposure to volatile organic compounds in humans
Christoph van Thriel, IFADO, Dortmund, Germany
RISK ASSESSMENT AND SPECIAL TOPICS
24. Benchmark dose and noncancer risk assessment for the upper airways
Bruce Winder, Karen Riveles & Andrew Salmon, California Environmental Protection Agency
25. Physico-chemical modeling of sensory irritation in humans and experimental animals
Michael H. Abraham, Ricardo Sánchez-Moreno & Javier Gil-Lostes - University College, London; J. Enrique Cometto-Muñiz & William S. Cain – University of Calif., San Diego
26. Effect of allergic inflammation on irritant responsiveness in the upper airways
Thomas E. Taylor-Clark & Bradley J. Undem, Johns Hopkins Medical School
27. Effect of air pollutants on allergic upper airway disease
Dennis Shusterman, Univ. of California, San Francisco
John B. Morris is Professor and Head of Pharmaceutical Sciences and Assistant Dean for Research at the University of Connecticut. He received his Ph.D. in Toxicology at the University of Rochester in 1979 and carried out a Postdoctoral fellowship in Inhalation Toxicology at New York University. In 1981 he joined the faculty at the University of Connecticut. Dr Morris has authored over 70 peer-review articles and book chapters. He is currently on the editorial board of Inhalation Toxicology.
Dennis J. Shusterman is Professor of Clinical Medicine, Emeritus at the University of California, San Francisco (UCSF). He received his M.D. from University of California, Davis in 1978, and M.P.H. from University of California, Berkley in 1982. He currently serves as a Section Chief within the Occupational Health Branch of the California Department of Public Health, and is an attending physician in the Occupational and Environmental Medicine Clinic at UCSF. He is the author of over 70 peer-reviewed publications in the field of inhalation toxicology and occupational and environmental medicine.