Pharmacogenetics of Breast Cancer. Towards the Individualization of Therapy. Translational Medicine

Informa Healthcare, May 2008, Pages: 352

Pharmacogenetics is becoming increasingly relevant in the diagnosis, treatment, and recovery of cancer patients. A major problem facing oncologists is the outstanding varied efficacy of treatment. Promising advances in pharmacogenetics have allowed the development of effective agents which will enable personalized cancer chemotherapy to become routine for the clinical practice.

Written by experts in the field and combining information that is unable to be found in a single source volume, Pharmacogenetics of Breast Cancer:

- combines a complete overview of pharmacogenetics and how it relates to breast oncology for diagnosis, treatment, and the recovery of patients using an individualized therapy model
- is the first single source reference demonstrating the application of pharmacogenetics in the care of breast cancer patients
- enables physicians a coherent interpretation of the emerging science of pharmacogenetics, aiding them to incorporate individual therapies in their own practice
- gives practical guidance on various forms of specimen collection, tissue selection, and handling procedures

Pharmacogenomic approaches. Individualized kinetics and dosing. Clasical IHC and FISH state of the art. Affy-based chemo and dosing. Panoply of genomic approaches. Epigenetics. Illumina-based platforms. Proteomics. Measurement of Pharmacodynamic endpoints. What tissues are needed + specimen collection

Brian Leyland-Jones Winship Cancer Institute, Emory University, Atlanta, Georgia.

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