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IL-1 Signaling Pathway in Oncology Drug Pipeline Update 2014 Product Image

IL-1 Signaling Pathway in Oncology Drug Pipeline Update 2014

  • Published: March 2014
  • Region: Global
  • Bioseeker

The IL-1 signaling pathway activates the MAPK/JNK signaling modules. The MAPK pathway leads to activation of NFkB complex. As both IL-1 and TNF alpha stimulate the MAPK signaling module and activate NFkB, they are synergistic and complement each other's activity.

There are today 85 companies plus partners developing 84 IL-1 pathway targeting drugs in 309 developmental projects in cancer. In addition, there is 1 suspended drug and the accumulated number of ceased drugs over the last years amount to another 45 drugs. Il-1 Signaling Pathway In Oncology Drug Pipeline Update lists all drugs and gives you a progress analysis on each one of them. Identified drugs are linked to 83 different targets. All included targets have been cross-referenced for the presence of mutations associated with human cancer. To date 79 out of the 82 studied drug targets so far have been recorded with somatic mutations. The software application lets you narrow in on these mutations and links out to the mutational analysis for each of the drug targets for detailed information. All drugs targets are further categorized on in the software application by 27 classifications of molecular function and with pathway READ MORE >



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