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Biomarkers in Clinical Pharmacology

Biomarkers are measurements that have become very powerful tools for drug development, medical practice, diagnosis and regulation throughout the healthcare sector. This Special Focus Issue of the peer-reviewed journal Biomarkers in Medicine includes 8 manuscripts highlighting the evaluation and use of biomarkers in medical practice and drug development. Numerous benefits are evident from the appropriate use of biomarkers, including more accurate and earlier diagnoses, individualized therapy, improved usage, and increased efficiency and quality of decision-making in drug development. Biomarkers continue to promise and deliver important effects throughout medical practice and the biomedical industry.
- Innovations driving biomarker evaluation and use
John A Wagner
Biomarkers in Medicine, December 2010, Vol. 4, No. 6, Pages 779-781.

- Beyond biomarkers: an opportunity to address the ‘pharmacodynamic gap' in pediatric drug development
Gregory L Kearns

- Translational medicine: path to personalized and public health
Andre Terzic, Scott A Waldman

- Research Highlights
Jason Park

- Book Review: Biomarkers in drug development: a handbook of practice, application and strategy
Paul Keown

- Restructuring proteomics through verification
Emily Boja, Robert Rivers, Christopher Kinsinger, Mehdi Mesri, Tara Hiltke, Amir Rahbar, Henry Rodriguez

- Emergence of biomarkers in nephropharmacology
Enver Khan, Vecihi Batuman, Juan J L Lertora

- Applications of ‘decisionable' biomarkers in cardiovascular drug development
Rajesh Krishna, John A Wagner
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